Fungal Infections
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity [Phase 1]
A Phase 1 pilot study examining gene expression profiling and clinical characterization of phototoxicity in pediatric and adult participants…
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CLINICAL_TRIALS trial_result · 2025-10-20Clinical Trial Update: Rezafungin Prophylaxis in Liver Transplant [Phase 3]
Phase 3 clinical trial update on rezafungin as prophylaxis to prevent fungal infections in liver transplant recipients; currently enrolling …
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Orally [Phase 1]
Phase 1 study evaluating the safety, pharmacokinetics, oral bioavailability, food effect, and drug-drug interactions of APX001 in fungal inf…
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: Trained Immunity in Fungal Infection and Its Mechanism [EARLY_Phase 1]
This early-phase clinical trial update reports completion of a study investigating whether Bacille Calmette-Guérin vaccination can induce tr…
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CLINICAL_TRIALS trial_result · 2024-05-17Clinical Trial Update: A Drug-Drug Interaction Study of CYP3A4 Inhibition and Pan-CYP Induction on APX001 [Phase 1]
Phase 1 study assessing the interaction between CYP3A4 inhibition and pan-CYP induction on APX001 (fosmanogepix) has completed.
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CLINICAL_TRIALS trial_result · 2020-12-28Clinical Trial Update: Bioequivalence (BE) Study of Test Griseofulvin 500 Milligram (mg) Tablets Versus Reference and Dose Proportionality Study of Test Griseofulvin 250 mg and 500 mg Tablets Under Fed Conditions [Phase 1]
Phase 1 BE and dose proportionality study evaluating test griseofulvin 500 mg tablets vs reference under fed conditions; completed with resu…
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CLINICAL_TRIALS trial_result · 2020-12-08Clinical Trial Update: CD101 Compared to Caspofungin Followed by Oral Step Down in Subjects With Candidemia and/or Invasive Candidiasis-Bridging Extension [Phase 2]
Phase 2 trial comparing CD101 to caspofungin followed by oral step-down in candidemia and invasive candidiasis completed; results posted.
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CLINICAL_TRIALS trial_result · 2020-08-21Clinical Trial Update: A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) [Phase 3]
Phase 3 trial comparing posaconazole with voriconazole for invasive aspergillosis is completed with posted results.
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CLINICAL_TRIALS trial_result · 2020-03-18Clinical Trial Update: Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection 200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in Healthy Volunteers [Phase 1]
Phase I pharmacokinetic comparison study of Vorico Injection 200mg versus Vfend IV 200mg in healthy volunteers completed with posted results…
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CLINICAL_TRIALS trial_result · 2017-10-10Clinical Trial Update: Antifungal Locks to Treat Fungal-related Central Line Infections [Phase 4]
Phase 4 trial evaluating antifungal lock therapy for treating fungal-related central line infections completed, with results posted.
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: Open, Pharmacokinetic Study of Caspofungin Acetate in Immunocompromised Young Children With Febrile Neutropenia (0991-042) [Phase 2]
This completed Phase 2 pharmacokinetic study evaluated caspofungin acetate in immunocompromised young children with febrile neutropenia to c…
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CLINICAL_TRIALS trial_result · 2016-11-15Clinical Trial Update: MALDITOF Versus Routine Clinical Microbiology for Identifying Pathogens; a Randomized Diagnostic Trial [NA]
A randomized diagnostic trial comparing MALDI-TOF mass spectrometry to routine clinical microbiology for identifying bacterial and fungal pa…
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CLINICAL_TRIALS trial_result · 2016-11-02Clinical Trial Update: Assessment of the Fungal Infection Incidence Across Canada for High Risk Participants With Hematological Disease (P07501)
This completed Canadian clinical trial assessed the incidence of fungal infections among high-risk participants with hematologic disease. Re…
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CLINICAL_TRIALS trial_result · 2016-05-23Clinical Trial Update: A Trial Comparing Efficacy and Safety of Voriconazole Administered With Therapeutic Drug Monitoring vs. Standard Dosing [Phase 4]
Phase 4 trial comparing voriconazole with therapeutic drug monitoring versus standard dosing for fungal infections; results have been posted…
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CLINICAL_TRIALS trial_result · 2016-04-15Clinical Trial Update: A Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children (P03579) [Phase 1]
Phase 1 study of oral posaconazole in immunocompromised children was terminated; results posted in 2016 regarding safety, tolerance, and pha…
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CLINICAL_TRIALS trial_result · 2016-03-28Clinical Trial Update: A Study to Compare Efficacy and Safety of Mycamine® and Itraconazole for Preventing Fungal Infections [Phase 3]
A Phase 3 trial comparing micafungin (Mycamine) to itraconazole for preventing fungal infections has completed.
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CLINICAL_TRIALS trial_result · 2015-09-24Clinical Trial Update: Pharmacokinetics of Posaconazole Prophylaxis in Acute Leukemia [Phase 2]
Phase 2 pharmacokinetics study of posaconazole prophylaxis in patients with acute leukemia and fungal infection.
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CLINICAL_TRIALS trial_result · 2015-09-02Clinical Trial Update: Safety of Fluconazole Treatment of Premature and Full-term Newborn Infants [Phase 4]
Phase 4 safety update evaluating fluconazole treatment in premature and full-term newborn infants.
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CLINICAL_TRIALS trial_result · 2015-07-07Clinical Trial Update: Safety and Efficacy of Posaconazole Oral Suspension in Usual Practice in Korea (P08547)
This clinical trial update reports on the safety and efficacy of posaconazole oral suspension in usual practice in Korea.
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CLINICAL_TRIALS trial_result · 2015-07-07Clinical Trial Update: Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B [Phase 4]
Phase 4 trial investigating spironolactone to prevent electrolyte abnormalities in patients receiving amphotericin B was terminated.
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CLINICAL_TRIALS trial_result · 2014-08-21Clinical Trial Update: A Study of Safety and Pharmacokinetics of Repeated Dose of Micafungin as Antifungal Prophylaxis in Children and Adolescents Who Undergo Hematopoietic Stem Cell Transplant [Phase 1]
A Phase 1 study evaluating the safety and pharmacokinetics of repeated-dose micafungin as antifungal prophylaxis in children and adolescents…
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CLINICAL_TRIALS trial_result · 2013-12-27Clinical Trial Update: A Study to Examine the Efficacy and Safety of Posaconazole When Introduced Early in the Treatment of Refractory Fungal Infections (P05090 AM2) [Phase 2]
Phase 2 study evaluating early use of posaconazole in treating refractory fungal infections; results assessing efficacy and safety were post…
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CLINICAL_TRIALS trial_result · 2013-06-19Clinical Trial Update: Voriconazole With or Without Interferon Gamma in Treating Patients With Aspergillosis or Other Fungal Infections [Phase 2]
Phase 2 trial evaluating voriconazole with or without interferon-gamma in patients with aspergillosis and other fungal infections; the study…
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CLINICAL_TRIALS trial_result · 2011-07-07Clinical Trial Update: Fluconazole Pharmacokinetics in Infants
This entry notes a completed clinical trial assessing the pharmacokinetics of fluconazole in infants.
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CLINICAL_TRIALS trial_result · 2011-05-12Clinical Trial Update: Beta Glucan Assay in Patients Receiving Voriconazole Prophylaxis [Phase 3]
Phase 3 trial evaluating a beta-glucan assay in patients on voriconazole prophylaxis; results completed and posted in 2011.