Fibrodysplasia Ossificans Progressiva
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: A Study to Assess the Effectiveness and Safety of 2 Dosage Regimens of Oral Fidrisertib (IPN60130) for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). [Phase 2]
Phase 2 trial evaluating two oral dosing regimens of fidrisertib (IPN60130) for fibrodysplasia ossificans progressiva has been terminated.
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: The Fibrodysplasia Ossificans Progressiva (FOP) Registry
This clinical trial registry entry describes the ongoing recruitment for the Fibrodysplasia Ossificans Progressiva (FOP) Registry, sponsored…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: A Study to Document and to Further Describe Long-term Safety and Effectiveness of Palovarotene in Participants With Fibrodysplasia Ossificans Progressiva (FOP)
Ipsen is conducting a long-term safety and effectiveness study of palovarotene in people with fibrodysplasia ossificans progressiva; the tri…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: IL1 Inhibition in FOP
A clinical trial is evaluating an IL-1–inhibiting therapy for fibrodysplasia ossificans progressiva and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP) [Phase 3]
A Phase 3 trial evaluating garetosmab versus placebo in adults with Fibrodysplasia Ossificans Progressiva; the study is active but not recru…
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: An Expanded Access Program of Garetosmab in Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)
This update describes Regeneron's expanded access program for garetosmab in adults with Fibrodysplasia Ossificans Progressiva (FOP), which i…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva [Phase 2]
This clinical trial update indicates that INCB000928 is being studied in Phase 2 for fibrodysplasia ossificans progressiva and is currently …
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: A Study of Andecaliximab in Participants With Fibrodysplasia Ossificans Progressiva (FOP) [Phase 2, Phase 3]
An update on a Phase 2/3 study of andecaliximab for Fibrodysplasia Ossificans Progressiva, sponsored by Ashibio Inc, currently active but no…
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CLINICAL_TRIALS trial_result · 2025-07-03Clinical Trial Update: A Non-Interventional Study of Clinical Characteristics and Mortality of US Patients With Fibrodysplasia Ossificans Progressiva (FOP)
This update reports on a completed non-interventional study collecting clinical characteristics and mortality data of US patients with fibro…
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed the Relevant Parent Studies. [Phase 3]
A completed Phase 3 rollover study evaluating the safety and efficacy of palovarotene capsules in participants with fibrodysplasia ossifican…
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FDA approval · 2025-03-13FDA Approved: SOHONOS — Supplemental Application (Ipsen Biopharmaceuticals, Inc.)
FDA approved a supplemental application for SOHONOS (palovarotene) by Ipsen Biopharmaceuticals, Inc., resulting in updated labeling that exp…
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CLINICAL_TRIALS trial_result · 2024-05-17Clinical Trial Update: An Open-Label Extension Study of Palovarotene Treatment in Fibrodysplasia Ossificans Progressiva (FOP) [Phase 2]
Open-label extension study of palovarotene for Fibrodysplasia Ossificans Progressiva (Phase 2) with results posted.
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CLINICAL_TRIALS trial_result · 2024-05-03Clinical Trial Update: Saracatinib Trial TO Prevent FOP [Phase 2]
A Phase 2 clinical trial evaluating saracatinib to prevent Fibrodysplasia Ossificans Progressiva is currently recruiting.
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FDA approval · 2023-08-16FDA Approved: SOHONOS — Original Application (Ipsen Biopharmaceuticals, Inc.)
FDA approves Sohonos (palovarotene) from Ipsen Biopharmaceuticals under an original application for the treatment of Fibrodysplasia ossifica…
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CLINICAL_TRIALS trial_result · 2023-03-14Clinical Trial Update: An Efficacy and Safety Study of Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva. [Phase 3]
Phase 3 trial of palovarotene for fibrodysplasia ossificans progressiva has completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-12-02Clinical Trial Update: A Study to Examine the Safety, Tolerability and Effects on Abnormal Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva [Phase 2]
Phase 2 trial update for REGN2477 in fibrodysplasia ossificans progressiva (FOP) evaluating safety, tolerability, and effects on abnormal bo…
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CLINICAL_TRIALS withdrawal · 2021-11-01Clinical Trial Update: Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP) [Phase 3]
Phase 3 trial evaluating garetosmab in Japanese adults with fibrodysplasia ossificans progressiva was withdrawn.
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects [Phase 2]
Phase 2 clinical trial evaluating episodic in-home administration of palovarotene in Fibrodysplasia Ossificans Progressiva has been terminat…
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CLINICAL_TRIALS trial_result · 2020-06-24Clinical Trial Update: An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects [Phase 2]
Phase 2 trial evaluating palovarotene for preosseous flare-ups in Fibrodysplasia Ossificans Progressiva has completed with results posted.
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CLINICAL_TRIALS trial_result · 2015-03-12Clinical Trial Update: Urine Sample Collection From FOP Patients
A completed clinical trial update noting urine sample collection from Fibrodysplasia Ossificans Progressiva patients (NCT02066324).