Familial Adenomatous Polyposis
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Sign up freeTop drugs studied for this disease
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FDA approval · 2015-08-21FDA Approved: CELECOXIB — Original Application (Alembic Pharmaceuticals Inc.)
FDA approved Alembic Pharmaceuticals' original application for a generic Celecoxib product. This marks the entry of a generic celecoxib into…
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FDA approval · 2015-06-09FDA Approved: CELECOXIB — Original Application (Lupin Pharmaceuticals, Inc.)
FDA approves Lupin Pharmaceuticals' Original Application for celecoxib, enabling a generic version of Celecoxib to enter the market.
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CLINICAL_TRIALS withdrawal · 2015-04-24Clinical Trial Update: A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP) [Phase 3]
A Phase 3 trial evaluating low-dose sulindac combined with eflornithine for Familial Adenomatous Polyposis has been withdrawn.
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CLINICAL_TRIALS trial_result · 2015-02-04Clinical Trial Update: Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polyposis [Phase 2]
Phase 2 trial evaluating celecoxib with or without eflornithine for prevention of colorectal cancer in patients with familial adenomatous po…
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CLINICAL_TRIALS trial_result · 2015-02-03Clinical Trial Update: Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version [Phase 4]
Phase 4 clinical trial exploring erythromycin as a readthrough agent for APC gene stop-codon mutations in minors with familial adenomatous p…
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CLINICAL_TRIALS trial_result · 2014-11-03Clinical Trial Update: Trial In Pediatric Patients With Familial Adenomatous Polyposis (FAP) [Phase 3]
Phase 3 pediatric trial in familial adenomatous polyposis (Adenomatous Polyposis Coli) was terminated; results posted in 2014.
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CLINICAL_TRIALS trial_result · 2014-09-10Clinical Trial Update: Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses [NA]
This terminated clinical trial evaluated a bioabsorbable staple line reinforcement device for colorectal, coloanal, and ileoanal anastomoses…
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CLINICAL_TRIALS trial_result · 2014-08-22Clinical Trial Update: Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA [Phase 2, Phase 3]
Phase 2/3 trial evaluated eicosapentaenoic acid (EPA) for chemoprevention in familial adenomatous polyposis; results were posted after compl…
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CLINICAL_TRIALS trial_result · 2014-06-26Clinical Trial Update: Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis [Phase 4]
A Phase 4 clinical trial update describes using erythromycin to promote readthrough of APC gene stop codons in Familial Adenomatous Polyposi…
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CLINICAL_TRIALS trial_result · 2014-06-12Clinical Trial Update: Dual Focus NBI and pCLE in FAP Related Duodenal Adenoma [NA]
A completed clinical trial evaluated dual imaging approaches (NBI and pCLE) for detecting duodenal adenomas in familial adenomatous polyposi…
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CLINICAL_TRIALS trial_result · 2014-02-24Clinical Trial Update: Indocyanine Green Fluorescent Molecular Imaging of the Gastrointestinal Tract [NA]
The study evaluated indocyanine green fluorescent imaging of the gastrointestinal tract in individuals with high-risk polyposis and distal c…
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CLINICAL_TRIALS trial_result · 2014-01-29Clinical Trial Update: An Evaluation of SprayShield in Reducing Post-Operative Adhesion Formation Following Major Open Abdominal Surgery [NA]
A terminated clinical trial evaluating SprayShield to reduce post-operative adhesion formation after major open abdominal surgery, with resu…
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CLINICAL_TRIALS withdrawal · 2013-07-24Clinical Trial Update: Exisulind in Preventing Polyps in Patients With Familial Adenomatous Polyposis [Phase 2, Phase 3]
This clinical trial update notes that the Phase 2/3 study of Exisulind to prevent polyps in patients with familial adenomatous polyposis has…
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CLINICAL_TRIALS trial_result · 2013-05-16Clinical Trial Update: Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis [Phase 2, Phase 3]
This ClinicalTrials.gov study in familial adenomatous polyposis evaluated prevention of progression of duodenal adenomas and has completed P…
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CLINICAL_TRIALS withdrawal · 2012-09-20Clinical Trial Update: Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients [Phase 2]
Phase 2 trial of curcumin for the lower gastrointestinal tract in patients with familial adenomatous polyposis was withdrawn.
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CLINICAL_TRIALS trial_result · 2012-05-23Clinical Trial Update: Endomicrocancer: Confocal Endomicroscopy in Patients With High Risk of Colorectal Cancer [NA]
A clinical trial update reports termination of the Endomicrocancer study evaluating confocal endomicroscopy in patients at high risk for col…
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CLINICAL_TRIALS withdrawal · 2011-07-06Clinical Trial Update: Coxib-inhibition of Duodenal Polyp Growth in FAP [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial evaluating a COX-2 inhibitor (coxib) for reducing duodenal polyps in patients with familial adenomatous pol…
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EMA guidance · 2011-05-20European Medicines Agency concludes on use of celecoxib in familial adenomatous polyposis
EMA concludes on the use of celecoxib for familial adenomatous polyposis (FAP), informing regulatory stance and potential labeling considera…
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CLINICAL_TRIALS trial_result · 2010-08-16Clinical Trial Update: Is Diverting Ileostomy Necessary in Stapled Ileoanal Pouch? [NA]
Completed clinical trial evaluating whether a diverting ileostomy is necessary after stapled ileoanal pouch creation for ulcerative colitis …
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CLINICAL_TRIALS trial_result · 2010-03-04Clinical Trial Update: Observational Familial Adenomatous Polyposis Registry Study In Patients Receiving Celecoxib Compared to Control Patients
A Pfizer-sponsored observational registry study in familial adenomatous polyposis comparing celecoxib-treated patients to controls; the stud…
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CLINICAL_TRIALS research · 2009-07-29Clinical Trial Update: Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) Patients [Phase 2, Phase 3]
Clinical trial update evaluating ursodeoxycholic acid for duodenal adenomas in familial adenomatous polyposis (FAP). The trial spans Phase 2…
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CLINICAL_TRIALS research · 2007-09-24Clinical Trial Update: Adenoma Detection Rate:NBI, AFI, Chromoscopic or Standard Endoscopy [NA]
This document provides an update on a trial evaluating adenoma detection rates using various endoscopy techniques (NBI, AFI, chromoscopic, a…
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CLINICAL_TRIALS research · 2007-08-10Clinical Trial Update: Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Polyposis [Phase 2]
Phase 2 clinical trial evaluating whether the combination of sulindac and probiotics can influence pouch adenoma development in patients wit…