Extensive-stage Small Cell Lung Cancer
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: A Phase II Study of QL1706 With Anti-angiogenesis Therapy and Chemotherapy in Extensive-stage Small Cell Lung Cancer. [Phase 2]
A Phase II clinical trial studying QL1706 combined with anti-angiogenesis therapy and chemotherapy in extensive-stage small cell lung cancer…
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: Small Extracellular Vesicle miRNAs as Predictive Biomarkers for Immunochemotherapy Efficacy in Extensive-stage Small Cell Lung Cancer
A clinical trial is currently recruiting to evaluate whether small extracellular vesicle miRNAs can serve as predictive biomarkers for the e…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Phase I Clinical Study of SHR-1316 (SC) Combined With Carboplatin and Etoposide as First-line Treatment for Extensive Stage Small Cell Lung Cancer [Phase 1]
Phase I study SHR-1316 combined with carboplatin and etoposide as first-line treatment for extensive-stage small cell lung cancer is current…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Pembrolizumab and Olaparib Treatment of Extensive Small Cell Lung Cancer (ES-SCLC) [Phase 2]
This clinical trial update notes recruitment for a Phase 2 study evaluating the combination of pembrolizumab and olaparib in extensive-stage…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Nano-crystalline Megestrol Acetate Combined With Standard Treatment Versus Standard Treatment for First-line Extensive-stage Small Cell Lung Cancer in the Cachexia Phase [Phase 3]
Phase 3 clinical trial evaluating adding nano-crystalline megestrol acetate to standard therapy versus standard therapy alone as first-line …
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Extensive-stage Small Cell Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating BL-B01D1 in combination with an anti-PD-1 monoclonal antibody for extensive-stage small cell lung cancer; …
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CLINICAL_TRIALS research · 2025-04-23Clinical Trial Update: Benmelstobart, Anlotinib and Chemotherapy as First-line Treatment for Extensive-stage Small-cell Lung Cancer [Phase 4]
A Phase 4 clinical trial evaluating Benmelstobart and Anlotinib in combination with chemotherapy as first-line treatment for extensive-stage…
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: Atezolizumab and Rechallenge Chemotherapy in Relapsed Patients With Extensive-stage Small Cell Lung Cancer (ES-SCLC). [Phase 2]
Phase 2 clinical trial evaluating atezolizumab with rechallenge chemotherapy in relapsed extensive-stage small cell lung cancer; currently r…
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: Second-line Immunotherapy for ES-SCLC [NA]
A second-line immunotherapy trial (NCT06853678) for extensive-stage small cell lung cancer is currently recruiting at Tianjin Medical Univer…
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CLINICAL_TRIALS research · 2025-01-27Clinical Trial Update: Nanocrystalline Megestrol + Immunochemo As 1st-Line for ES-SCLC Cachexia [Phase 2]
A Phase 2 trial of nanocrystalline Megestrol plus an immunochemotherapy regimen as first-line therapy for cachexia in extensive-stage small …
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CLINICAL_TRIALS research · 2025-01-17Clinical Trial Update: First Line Therapy for Extensive SCLC Patients, Treated with Chemo+Keytruda Followed by Keytuda+Trodelvy [Phase 2]
Ongoing Phase 2 trial evaluating first-line chemotherapy plus pembrolizumab, followed by pembrolizumab plus sacituzumab govitecan in extensi…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: Assessment of Adebelizumab Combined with Chemotherapy in Concurrent Radiotherapy Versus Sequential Radiotherapy As First-Line Treatment for Extensive-Stage Small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial evaluates Adebelizumab in combination with chemotherapy, with concurrent versus sequential radiotherapy as first-li…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: Phase II Study of Ivonescimab and Cadonilimab in Combination with Chemotherapy in Patients with ES-SCLC [Phase 2]
This is a Phase II clinical trial evaluating Ivonescimab and Cadonilimab in combination with chemotherapy for extensive-stage small cell lun…
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CLINICAL_TRIALS research · 2025-01-06Clinical Trial Update: Adebrelimab Plus Apatinib for Maintenance Therapy of Extensive Stage Small Cell Lung Cancer [NA]
A recruiting clinical trial evaluating the combination of Adebrelimab and Apatinib as maintenance therapy for extensive-stage small cell lun…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Low-dose Radiotherapy Combined with Concurrent Chemotherapy, Toripalimab and Tifcemalimab in the Treatment of ES-SCLC [Phase 1]
This document describes a Phase 1 clinical trial evaluating the combination of low-dose radiotherapy with concurrent chemotherapy, toripalim…
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CLINICAL_TRIALS research · 2024-12-19Clinical Trial Update: A Real-World Assessment of the Demographic, Clinical Characteristics and Outcomes of a Brazilian Cohort of Previously Untreated Extensive Stage-Small Cell Lung Cancer Receiving Durvalumab Combined With Platinum-Etoposide in (ES-SCLC) in Brazil
A real-world study in Brazil evaluates demographic, clinical characteristics and outcomes of previously untreated extensive-stage small cell…
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CLINICAL_TRIALS research · 2024-12-05Clinical Trial Update: Addition of Thoracic Consolidation Radiotherapy to the Maintenance Immunotherapy for ES-SCLC (STONE-001) [Phase 3]
A Phase 3 trial (STONE-001) is evaluating the addition of thoracic consolidation radiotherapy to maintenance immunotherapy for extensive-sta…
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: Efficacy and Safety of First-line Treatment for Extensive-stage Small Cell Lung Cancer Using a Combination Therapy of Trilaciclib, Envafolimab, Etoposide, and Carboplatin [Phase 2]
A Phase 2 trial evaluating first-line therapy for extensive-stage small cell lung cancer using a combination of trilaciclib, envafolimab, et…
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CLINICAL_TRIALS research · 2024-11-15Clinical Trial Update: A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies [Phase 1, Phase 2]
Clinical trial registry entry for a Phase 1/2a study of 23ME-00610 in patients with advanced solid malignancies, including several gynecolog…
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CLINICAL_TRIALS research · 2024-11-05Clinical Trial Update: Adebrelimab Combined with Chemotherapy and Thoracic Radiotherapy for First-line Treatment of ES-SCLC [Phase 3]
Phase 3 trial evaluating Adebrelimab with chemotherapy and thoracic radiotherapy as first-line treatment for extensive-stage small cell lung…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: Auto-HSCT-Supported Dose-Dense Chemotherapy with Adebrelimab As First-Line Treatment for ES-SCLC [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating auto-HSCT-supported dose-dense chemotherapy plus adebrelimab as first-line treatment for extensive-sta…
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CLINICAL_TRIALS research · 2024-09-26Clinical Trial Update: A Study of Adebelimab Combined With Chemotherapy as a First-line Treatment Sequential Treatment for Extensive-stage Small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial evaluating adebelimab in combination with chemotherapy as first-line treatment for extensive-stage small cell lung …
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Radiotherapy to All Residual Lesions After Chemoimmunotherapy [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating radiotherapy to all residual lesions after chemoimmunotherapy in extensive-stage small cell lung cance…
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CLINICAL_TRIALS research · 2024-07-31Clinical Trial Update: A Multicenter Real-World Cohort Study of Adebrelimab Injection in the Treatment of Extensive-Stage Small Cell Lung Cancer
This update outlines a multicenter real-world cohort study evaluating Adebrelimab injections for extensive-stage small cell lung cancer, whi…
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CLINICAL_TRIALS research · 2024-07-08Clinical Trial Update: A Study to Investigate the Efficacy and Safety of Ivonescimab Combined With Irinotecan Liposome as Second-line Regimen for ES-SCLC [Phase 2]
Phase 2 clinical trial update evaluating Ivonescimab with liposomal irinotecan as second-line therapy for extensive-stage small cell lung ca…