Estrogen Receptor-positive Advanced Breast Cancer

• CLINICAL_TRIALS research · 2026-04-08
  Clinical Trial Update: A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]

  First-in-human dose-escalation and expansion trial of AZD8421 (alone or in combination) in selected advanced solid tumors, including ER+ HER…

• CLINICAL_TRIALS research · 2026-04-06
  Clinical Trial Update: A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer) [Phase 3]

  A Phase 3 study evaluating the efficacy and safety of giredestrant compared with fulvestrant (plus a CDK4/6 inhibitor) in ER-positive, HER2-…

• CLINICAL_TRIALS trial_result · 2019-04-01
  Clinical Trial Update: An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker Analysis [Phase 4]

  Phase 4 open-label study in postmenopausal women with estrogen receptor–positive locally advanced or metastatic breast cancer evaluating eve…