Estrogen Receptor-positive Breast Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2022-03-22Clinical Trial Update: ER+/HER2- Locally Advanced or Metastatic Breast Cancer (ENZENO Study) [Phase 1, Phase 2]
Phase 1/2 trial update for an ER+/HER2- breast cancer candidate (ENZENO) in locally advanced or metastatic disease; current status unknown.
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CLINICAL_TRIALS trial_result · 2021-10-15Clinical Trial Update: Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer [Phase 2]
Phase 2 trial investigating palbociclib with either letrozole or fulvestrant in estrogen receptor-positive, HER2-negative metastatic breast …
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CLINICAL_TRIALS trial_result · 2021-10-13Clinical Trial Update: Neoadjuvant With Trastuzumab, Pyrotinib Plus Palbociclib and Fulvestrant in HER2-positive, ER-positive Breast Cancer [Phase 2]
Phase 2 clinical trial evaluating neoadjuvant trastuzumab, pyrotinib plus palbociclib and fulvestrant in HER2-positive, ER-positive breast c…
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CLINICAL_TRIALS trial_result · 2021-09-28Clinical Trial Update: Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer [Phase 2]
Phase 2 trial evaluating tamoxifen citrate or Z-Endoxifen hydrochloride in locally advanced or metastatic estrogen receptor-positive, HER2-n…
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CLINICAL_TRIALS trial_result · 2021-09-27Clinical Trial Update: A Phase II Study Comparing The Efficacy Of Venetoclax + Fulvestrant Vs. Fulvestrant In Women With Estrogen Receptor-Positive, Her2-Negative Locally Advanced Or Metastatic Breast Cancer Who Experienced Disease Recurrence Or Progression During Or After CDK4/6 Inhibitor Therapy [Phase 2]
Phase II trial comparing venetoclax plus fulvestrant versus fulvestrant alone in ER+/HER2-negative locally advanced or metastatic breast can…
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CLINICAL_TRIALS trial_result · 2021-08-11Clinical Trial Update: Atezolizumab and Cobimetinib or Idasanutlin in Participants With Stage IV or Unresectable Recurrent Estrogen Receptor Positive Breast Cancer [Phase 1, Phase 2]
Clinical trial evaluating atezolizumab with cobimetinib or idasanutlin in stage IV or unresectable recurrent estrogen receptor-positive brea…
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CLINICAL_TRIALS trial_result · 2021-08-03Clinical Trial Update: Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases [Phase 2]
Phase 2 clinical trial evaluating neoadjuvant response-guided treatment for luminal B and luminal A tumors with node metastases in early-sta…
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CLINICAL_TRIALS trial_result · 2021-07-27Clinical Trial Update: TAK-228 Plus Tamoxifen in Patients With ER-Positive, HER2-negative Breast Cancer [Phase 2]
Phase 2 trial evaluating TAK-228 in combination with tamoxifen for ER-positive, HER2-negative breast cancer has completed with results poste…
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CLINICAL_TRIALS trial_result · 2021-06-18Clinical Trial Update: Assessment of Safety and Efficacy of Estetrol in Postmenopausal Women With Advanced Estrogen Receptor Positive (ER+) Breast Cancer [Phase 1, Phase 2]
Clinical trial update evaluating safety and efficacy of estetrol in postmenopausal women with advanced estrogen receptor-positive breast can…
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CLINICAL_TRIALS trial_result · 2021-04-23Clinical Trial Update: MEDI4736 and Tremelimumab in Treating Patients With Metastatic HER2 Negative Breast Cancer [Phase 2]
Phase 2 trial update evaluating MEDI4736 (durvalumab) and tremelimumab in metastatic HER2-negative breast cancer has completed with posted r…
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CLINICAL_TRIALS trial_result · 2021-03-11Clinical Trial Update: Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer [Phase 2]
Phase II trial of the CDK inhibitor PD 0332991 (palbociclib) in various adult solid tumors including colon and breast cancers has completed …
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CLINICAL_TRIALS trial_result · 2020-12-29Clinical Trial Update: Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alobresib (Formerly GS-5829) in Adults With Advanced Solid Tumors and Lymphomas and in Combination With Exemestane or Fulvestrant in Adults With Estrogen Receptor Positive Breast Cancer [Phase 1]
Phase 1 study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics of alobresib (GS-5829) in adults with advanced solid t…
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CLINICAL_TRIALS trial_result · 2020-10-01Clinical Trial Update: Letrozole and Metronomic Capecitabine in ER-positive HER2 Negative Advanced Breast Cancer (B-001 Study) [Phase 2]
Phase 2 clinical trial update evaluating letrozole with metronomic capecitabine in ER-positive, HER2-negative advanced/metastatic breast can…
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CLINICAL_TRIALS trial_result · 2020-09-30Clinical Trial Update: Durvalumab and Endocrine Therapy in ER+/Her2- Breast Cancer After CD8+ Infiltration Effective Immune-Attractant Exposure [Phase 2]
Phase 2 trial evaluating durvalumab in combination with endocrine therapy for ER+/HER2- breast cancer after an immune-attractant exposure; s…
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CLINICAL_TRIALS trial_result · 2020-09-21Clinical Trial Update: Mucoadhesive Oral Wound Rinse in Preventing and Treating Stomatitis in Patients With ER- or PR-Positive Metastatic or Locally Recurrent Breast Cancer That Cannot be Removed by Surgery Receiving Everolimus [Phase 2]
Phase 2 clinical trial evaluating a mucoadhesive oral wound rinse to prevent and treat stomatitis in patients with ER- or PR-positive metast…
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CLINICAL_TRIALS trial_result · 2020-04-28Clinical Trial Update: Biomarkers in Tissue Samples From Patients With Newly Diagnosed Breast Cancer Treated With Zoledronic Acid [NA]
A terminated clinical trial investigating biomarkers in tissue samples from newly diagnosed breast cancer patients treated with zoledronic a…
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CLINICAL_TRIALS trial_result · 2020-02-11Clinical Trial Update: F-18 FES PET/CT in Measuring Hormone Expression in Patients With Primary, Recurrent, or Metastatic Breast Cancer Undergoing Endocrine-Targeted Therapy [NA]
Clinical trial assessing F-18 FES PET/CT to measure hormone expression in estrogen receptor–positive breast cancer during endocrine-targeted…
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CLINICAL_TRIALS trial_result · 2020-01-27Clinical Trial Update: Letrozole and Imatinib Mesylate in Treating Postmenopausal Participants With Estrogen or Progesterone Positive Metastatic Breast Cancer [Phase 2]
Phase 2 clinical trial investigating letrozole in combination with imatinib mesylate for postmenopausal women with estrogen receptor–positiv…
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CLINICAL_TRIALS trial_result · 2019-10-24Clinical Trial Update: Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Advanced Breast Cancer [Phase 2]
Phase 2 clinical trial evaluating exemestane with or without entinostat (SNDX-275) in postmenopausal women with advanced estrogen receptor-p…
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CLINICAL_TRIALS trial_result · 2019-02-01Clinical Trial Update: CYP17 Lyase and Androgen Receptor Inhibitor Treatment With Seviteronel Trial (INO-VT-464-006; NCT02580448) [Phase 1, Phase 2]
This document reports the completion of a Phase 1/Phase 2 clinical trial evaluating seviteronel, a CYP17 lyase and androgen receptor inhibit…
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CLINICAL_TRIALS trial_result · 2018-10-17Clinical Trial Update: Pilot Study Estradiol Followed by Exemestane Hormone Receptor + Metastatic Breast Cancer [NA]
Pilot study evaluating estradiol followed by exemestane in hormone receptor-positive metastatic breast cancer; trial completed with posted r…
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CLINICAL_TRIALS trial_result · 2018-07-27Clinical Trial Update: A Study of Abiraterone Acetate Plus Prednisone With or Without Exemestane in Postmenopausal Women With Estrogen Receptor-Positive (ER+) Metastatic Breast Cancer Progressing After Letrozole or Anastrozole Therapy [Phase 2]
Phase 2 trial evaluating abiraterone acetate plus prednisone with or without exemestane in postmenopausal women with estrogen receptor-posit…
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CLINICAL_TRIALS trial_result · 2018-07-26Clinical Trial Update: Neo-adjuvant Therapy With Anastrozole Plus Pazopanib in Stage II and III ER+ Breast Cancer [Phase 2]
A phase 2 neoadjuvant trial of anastrozole plus pazopanib in stage II/III estrogen receptor-positive, HER2-negative breast cancer was termin…
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CLINICAL_TRIALS trial_result · 2018-07-23Clinical Trial Update: MK2206 in Combination With Anastrozole, Fulvestrant, or Anastrozole and Fulvestrant in Treating Postmenopausal Women With Metastatic Breast Cancer [Phase 1]
Phase 1 trial evaluating MK-2206 in combination with anastrozole and/or fulvestrant in postmenopausal women with metastatic breast cancer; s…
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CLINICAL_TRIALS trial_result · 2018-05-08Clinical Trial Update: Akt Inhibitor MK-2206 and Anastrozole With or Without Goserelin Acetate in Treating Patients With Stage II-III Breast Cancer [Phase 2]
Phase 2 trial evaluating MK-2206 with anastrozole, with or without goserelin acetate, in stage II-III breast cancer; the study was terminate…