Estrogen Receptor-positive Breast Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-06-05Clinical Trial Update: Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing Surgery [Phase 3]
A Phase 3 clinical trial evaluating fulvestrant and/or anastrozole for postmenopausal patients with stage II-III estrogen receptor-positive,…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Independent, External, Blinded Retrospective Validation of an AI-based Prognostic Assay in ER-Positive/HER2-Negative Early Breast Cancer
This clinical trial update describes an independent, external, blinded retrospective validation of an AI-based prognostic assay for ER-posit…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: High Cannabidiol Plant Extract (BRC-001) to Improve Aromatase Inhibitor-Induced Arthralgia in Women With Breast Cancer [Phase 2]
Phase 2 clinical trial updates show BRC-001, a cannabidiol plant extract, being studied to improve aromatase inhibitor-induced arthralgia in…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Z-Endoxifen Hydrochloride in Treating Patients With Metastatic or Locally Recurrent Estrogen Receptor-Positive Breast Cancer [Phase 1]
This clinical trial update reports on Z-Endoxifen Hydrochloride being studied for estrogen receptor-positive breast cancer that is metastati…
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: Circulating Tumor DNA Based Minimal Residual Disease Detection for Patients With Early-Stage Breast Cancer [NA]
The study evaluating circulating tumor DNA–based minimal residual disease detection in early-stage breast cancer is currently suspended.
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: A Window-of-Opportunity Trial of Giredestrant +/- Triptorelin vs. Anastrozole + Triptorelin in Premenopausal Patients With ER-positive/HER2-negative Early Breast Cancer [Phase 2]
A Phase 2 window-of-opportunity trial in premenopausal patients with ER-positive, HER2-negative early breast cancer comparing giredestrant w…
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: Pembrolizumab, Endocrine Therapy, and Palbociclib in Treating Postmenopausal Patients With Newly Diagnosed Metastatic Stage IV Estrogen Receptor Positive Breast Cancer [Phase 2]
This Phase 2 trial evaluates pembrolizumab in combination with endocrine therapy and palbociclib for postmenopausal patients with newly diag…
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer) [Phase 3]
Phase 3 clinical trial update on evaluating giredestrant versus physician's choice of adjuvant endocrine therapy for estrogen receptor-posit…
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: Vepdegestrant (ARV-471/PF-07850327) + Palbociclib vs Letrozole + Palbociclib in ER(+)/HER2(-) Advanced Breast Cancer [Phase 3]
Phase 3 trial comparing Vepdegestrant (ARV-471) plus palbociclib vs letrozole plus palbociclib in ER-positive/HER2-negative advanced breast …
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CLINICAL_TRIALS trial_result · 2026-01-30Clinical Trial Update: A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer) [Phase 3]
Phase 3 clinical trial update comparing giredestrant plus everolimus to physician's choice endocrine therapy plus everolimus in estrogen rec…
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Fulvestrant and Ipatasertib for Advanced HER-2 Negative and Estrogen Receptor Positive (ER+) Breast Cancer Following Progression on First Line CDK 4/6 Inhibitor and Aromatase Inhibitor [Phase 3]
A Phase 3 trial evaluating the combination of fulvestrant and ipatasertib in advanced ER-positive, HER2-negative breast cancer after progres…
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications [Phase 1]
A Phase 1 clinical trial update describes evaluation of BBI-355 (CHK1 inhibitor) in combination with BBI-825 (RNR inhibitor) for tumors with…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Umbrella Trial of Subtype-Targeted Therapies in ER+/HER2- Breast Cancer [Phase 2]
A Phase 2 umbrella trial testing subtype-targeted therapies for estrogen receptor-positive, HER2-negative breast cancer has completed, and r…
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: Evaluation of a Once Per Day Regimen of Accelerated Partial Breast Irradiation for Improved Breast Appearance in Pts w/Low Risk, Hormone Responsive Brst Ca [Phase 2]
Phase 2 trial evaluating a once-daily accelerated partial breast irradiation regimen for low-risk, hormone receptor-positive breast cancer; …
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CLINICAL_TRIALS trial_result · 2025-10-14Clinical Trial Update: A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease [Phase 3]
Phase 3 trial comparing AZD9833 plus palbociclib versus anastrozole plus palbociclib in ER-positive, HER2-negative breast cancer patients wh…
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CLINICAL_TRIALS trial_result · 2025-09-26Clinical Trial Update: ARV-471 in Combination With Everolimus for the Treatment of Advanced or Metastatic ER+, HER2- Breast Cancer [Phase 1]
A Phase 1 trial update reports completion of results for ARV-471 in combination with everolimus in advanced or metastatic estrogen receptor‑…
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: [18F]FES PET/CT in Endocrine Refractory Breast Cancer [Phase 2]
Phase 2 trial evaluating [18F]fluoroestradiol PET/CT imaging in estrogen receptor-positive breast cancer has completed.
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Impact of Endocrine Therapy and Abemaciclib on Host and Tumor Immune Cell Repertoire/Function in Advanced ER+/HER2- Breast Cancer [Phase 2]
Phase 2 trial evaluating the impact of combining endocrine therapy with abemaciclib on host and tumor immune cell repertoire in advanced ER+…
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: A Study to See Whether Estrogen Can Slow the Growth of Some ER Positive Breast Cancers [Phase 2]
This Phase 2 clinical trial aims to determine if estrogen can slow the growth of estrogen receptor-positive breast cancers. The study, spons…
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CLINICAL_TRIALS trial_result · 2025-04-10Clinical Trial Update: Biology Guided Therapy for Breast Cancer for ER Positive [Phase 2]
A Phase 2 biology-guided therapy trial for estrogen receptor-positive breast cancer was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2025-02-27Clinical Trial Update: Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer [Phase 2]
Phase 2 clinical trial update evaluating correlation between clinical response and pathologic response in patients with early breast cancer.
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CLINICAL_TRIALS trial_result · 2025-02-25Clinical Trial Update: Trial of H3B-6545, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast Cancer [Phase 1, Phase 2]
Completed Phase 1/2 trial evaluating H3B-6545 in women with locally advanced or metastatic ER-positive, HER2-negative breast cancer; results…
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CLINICAL_TRIALS trial_result · 2025-02-17Clinical Trial Update: Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis [Phase 2]
A Phase 2 clinical trial evaluating the combination of radiation therapy, palbociclib, and endocrine (hormone) therapy in patients with estr…
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: Evaluation of Lasofoxifene Combined With Abemaciclib in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation [Phase 2]
Phase 2 trial evaluating lasofoxifene in combination with abemaciclib in advanced or metastatic ER+/HER2- breast cancer with ESR1 mutation h…
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: A Study of AC682 for the Treatment of Locally Advanced or Metastatic ER+ Breast Cancer [Phase 1]
A Phase 1 clinical trial evaluating AC682 for locally advanced or metastatic estrogen receptor-positive breast cancer has been terminated.