Estrogen Receptor-positive Breast Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor [Phase 2]
Phase 2 clinical trial evaluating a genetically-informed therapy for estrogen receptor-positive breast cancer after CDK4/6 inhibitor treatme…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Phase II Study of Neoadjuvant ArOMatase Inhibitor Therapy for ER+ Breast Cancer (NAOMI) [Phase 2]
The NAOMI Phase II trial is evaluating neoadjuvant aromatase inhibitor therapy for estrogen receptor-positive breast cancer. The study is cu…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Phase Ib/II Clinical Study of QLS1304 Combined With Endocrine Therapy in the Treatment of ER+/HER2- Breast Cancer Patients [Phase 1, Phase 2]
This clinical trial update indicates that a Phase Ib/II study evaluating QLS1304 in combination with endocrine therapy for advanced ER+/HER2…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: A Phase Ib/II Study to Evaluate Multiple Combination Therapies of FWD1802 in Patients With ER+/HER2- BC [Phase 1, Phase 2]
A Phase Ib/II clinical trial is evaluating multiple combination therapies with FWD1802 in ER+/HER2- breast cancer and related stages, and is…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC [Phase 2]
This clinical trial update covers a Phase 2 study evaluating sequencing of antibody-drug conjugates in estrogen receptor-positive, HER2-low/…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: FES Imaging to Optimize Tamoxifen for Metastatic Breast Cancer [EARLY_Phase 1]
An early-phase clinical study evaluating FES imaging to optimize tamoxifen therapy in estrogen receptor–positive metastatic breast cancer, i…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Combined Immunotherapies in Metastatic ER+ Breast Cancer [Phase 2]
This clinical trial update notes a Phase 2 study evaluating combined immunotherapies for metastatic estrogen receptor-positive breast cancer…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Personalised Disease Monitoring in Metastatic Breast Cancer
This ClinicalTrials.gov entry reports an active but not recruiting study evaluating personalised disease monitoring in metastatic, estrogen …
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Fulvestrant +/- Akt Inhibition in Advanced Aromatase Inhibitor Resistant Breast Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating fulvestrant with or without an AKT inhibitor in advanced aromatase inhibitor-resistant estrogen recept…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer [Phase 4]
Phase 4 clinical trial updating on the use of the PET tracer [18F]-FES to image estrogen receptor–positive breast cancer with brain metastas…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Marker - Adjusted Therapy Comparing Adjuvant Elacestrant With Standard Endocrine Treatment in Genomically and/or Clinically High-risk ER+/HER2- eBC [Phase 3]
Phase 3 trial evaluating adjuvant elacestrant versus standard endocrine therapy in high-risk ER+/HER2- breast cancer is currently not recrui…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Breast Re-irradiation After Second Ipsilateral Lumpectomy [NA]
This document provides an update on a clinical trial evaluating breast re-irradiation after a second ipsilateral lumpectomy.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial [Phase 2]
Phase 2 trial evaluating imlunestrant in combination with abemaciclib for estrogen receptor-positive breast cancer with minimal residual dis…
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer [Phase 2]
A Phase 2 clinical trial update for Z-Endoxifen in premenopausal women with ER-positive, HER2-negative breast cancer, currently recruiting.
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer [Phase 1]
Olema Pharmaceuticals reports a Phase 1b trial evaluating OP-1250 (palazestrant) in combination with ribociclib, alpelisib, everolimus, or a…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: Elacestrant vs Elacestrant Plus a CDK4/6 Inhibitor in Patients With ERpositive/HER2-negative Advanced or Metastatic Breast Cancer [Phase 2]
Phase 2 clinical trial evaluating elacestrant alone versus elacestrant plus a CDK4/6 inhibitor in ER-positive, HER2-negative advanced or met…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer [Phase 2]
Phase 2 trial investigating stereotactic body radiation therapy with FES PET/CT imaging for oligoprogressive estrogen receptor–positive meta…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer [Phase 2]
A Phase 2 clinical trial is evaluating adaptive therapy with capecitabine for metastatic estrogen receptor-positive, HER2-negative breast ca…
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: Evaluation of a Novel Technique for the Discovery of New, Tumor-specific Targets for the Deployment of Innovative Immunotherapeutics Against Cancer. [NA]
This clinical trial update describes a University Ghent study evaluating a novel technique to identify tumor-specific targets for the deploy…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA) [Phase 3]
Phase 3 clinical trial investigating elacestrant for estrogen receptor-positive, HER2-negative breast cancer with ctDNA relapse (TREAT ctDNA…
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CLINICAL_TRIALS research · 2025-07-30Clinical Trial Update: DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs [Phase 2]
A Phase 2 trial of datopotamab deruxtecan (DATO-BASE) for breast cancer with brain metastases is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Lenvatinib+Letrozole Versus Fulvestrant in Metastatic ER+/HER2- Breast Cancer, Post Progression on Al + CDK4/6 Inhibitor [Phase 2]
Phase 2 trial evaluating lenvatinib plus letrozole versus fulvestrant in metastatic ER+/HER2- breast cancer after progression on an aromatas…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Role of the Immune Environment in Response to Therapy in Breast Cancer
A clinical trial update from Penn Medicine describes a study on how the immune environment influences response to therapy in breast cancer, …
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer [Phase 2]
Phase 2 clinical trial update (SAPPHO) evaluating sequential curative-intent therapy in newly diagnosed de novo HER2-positive metastatic bre…
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CLINICAL_TRIALS research · 2025-06-13Clinical Trial Update: Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt) [Phase 2]
Phase 2 clinical trial update (KePreSt) assessing the effects of ketorolac and pregabalin in early-stage, estrogen receptor-positive breast …