Esophageal Carcinoma

• CLINICAL_TRIALS trial_result · 2026-08-03
  Clinical Trial Results: A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer) [Phase 1, Phase 2]

  Phase 1/2 study evaluating multiple immunotherapy-based combinations in locally advanced unresectable or metastatic gastric/GEJ cancer and e…

• CLINICAL_TRIALS research · 2026-04-07
  Clinical Trial Update: Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays [NA]

  A clinical trial is evaluating the PAGODA algorithm for adjusting chemotherapy doses to prevent unplanned treatment delays. The study is cur…

• CLINICAL_TRIALS research · 2026-02-18
  Clinical Trial Update: Inter-Observer Delineation Differences in Esophageal Cancer GTV on MR, CT, and PET/CT Protokol šečerov Ermenc 28dec19 [NA]

  This trial update examines inter-observer variability in delineating esophageal cancer gross tumor volume (GTV) using MR, CT, and PET/CT ima…

• CLINICAL_TRIALS research · 2025-12-15
  Clinical Trial Update: A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer) [Phase 1, Phase 2]

  A Roche-sponsored Phase 1/2 clinical trial evaluating multiple immunotherapy-based treatment combinations in patients with locally advanced …

• CLINICAL_TRIALS research · 2024-09-25
  Clinical Trial Update: A Study to Evaluate Nivolumab in the Treatment of Early Stage Esophageal or Gastroesophageal Cancer

  A clinical trial evaluating nivolumab for early-stage esophageal or gastroesophageal junction cancer has been terminated.

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• CLINICAL_TRIALS trial_result · 2023-03-21
  Clinical Trial Update: Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma [Phase 1, Phase 2]

  A combined neoadjuvant PD-1 blockade with chemotherapy trial for esophageal carcinoma is in Phase 1/2 with unclear status.

• CLINICAL_TRIALS trial_result · 2023-02-16
  Clinical Trial Update: Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer [Phase 2]

  Phase 2 clinical trial evaluating botulinum toxin type A to prevent complications after esophageal cancer surgery.

• CLINICAL_TRIALS trial_result · 2021-01-06
  Clinical Trial Update: Staging and Outcome Depending on Surgical Treatment in Adenocarcinomas of the Oesophagogastric Junction

  Clinical trial update on staging and outcomes based on surgical treatment for adenocarcinomas at the oesophagogastric junction; results comp…

• CLINICAL_TRIALS trial_result · 2020-07-01
  Clinical Trial Update: Feasibility Study of Chemoradiation, TRAstuzumab and Pertuzumab in Resectable HER2+ Esophageal Carcinoma [Phase 1, Phase 2]

  Feasibility study evaluating chemoradiation with trastuzumab and pertuzumab in resectable HER2-positive esophageal carcinoma; study complete…

• CLINICAL_TRIALS trial_result · 2020-06-22
  Clinical Trial Update: Epacadostat and Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Junction or Gastric Cancer [Phase 2]

  Phase 2 trial updating epacadostat plus pembrolizumab in metastatic or unresectable gastroesophageal junction or gastric cancer (completed; …

• CLINICAL_TRIALS trial_result · 2020-03-26
  Clinical Trial Update: Robot-assisted Thoraco-laparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy [Phase 3]

  Phase 3 trial comparing robot-assisted thoraco-laparoscopic esophagectomy to open transthoracic esophagectomy for esophageal cancer has comp…

• CLINICAL_TRIALS trial_result · 2020-02-26
  Clinical Trial Update: Study of Pembrolizumab (MK-3475) Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal/Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)-China Extension Study [Phase 3]

  Phase 3 trial comparing pembrolizumab to investigator's choice chemotherapy in advanced esophageal/esophagogastric junction carcinoma after …

• CLINICAL_TRIALS trial_result · 2019-11-20
  Clinical Trial Update: Study of Pembrolizumab (MK-3475) Versus Investigator's Choice Standard Therapy for Participants With Advanced Esophageal/ Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181) [Phase 3]

  Phase 3 trial of pembrolizumab vs investigator's choice for advanced esophageal/esophagogastric junction carcinoma after first-line therapy;…

• CLINICAL_TRIALS trial_result · 2019-10-01
  Clinical Trial Update: Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy [Phase 2]

  Phase 2 clinical trial evaluating doxepin hydrochloride for treating esophageal pain in thoracic cancer patients receiving radiation therapy…

• CLINICAL_TRIALS trial_result · 2019-07-17
  Clinical Trial Update: Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus or Esophagogastric Junction (MK-3475-180/KEYNOTE-180) [Phase 2]

  Phase 2 trial of pembrolizumab in previously treated advanced esophageal/eg junction carcinoma completed with results posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-07-05
  Clinical Trial Update: Second-line Treatment With Icotinib in Esophageal Carcinoma Patients With EGFR Overexpression (IHC 3+) or Positive FISH [Phase 2]

  Phase 2 trial evaluating icotinib as second-line treatment in esophageal carcinoma/esophagogastric junction adenocarcinoma with EGFR overexp…

• CLINICAL_TRIALS trial_result · 2015-05-15
  Clinical Trial Update: Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia [Phase 2]

  Phase 2 trial update on Ursodiol for Barrett esophagus with low-grade dysplasia completed; results posted in 2015.

• CLINICAL_TRIALS withdrawal · 2013-11-19
  Clinical Trial Update: Study of Cetuximab and Bevacizumab in Cancer of the Esophagus After Failure of Patient's First Therapy [Phase 2]

  A Phase 2 trial evaluating cetuximab in combination with bevacizumab for esophageal carcinoma after failure of first-line therapy has been w…