Epilepsy
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Sign up freeTop drugs studied for this disease
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FDA approval · 2018-06-19FDA Approved: TOPAMAX — Supplemental Application (Janssen Pharmaceuticals, Inc.)
The FDA approved a supplemental application for Topamax (topiramate) submitted by Janssen Pharmaceuticals, Inc.
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CLINICAL_TRIALS trial_result · 2018-06-19Clinical Trial Update: An Open-label, Single-centre Study Evaluating the Pharmacokinetics of Digoxin Alone and When Administered at Various Doses of Ezogabine/Retigabine in Healthy Adults. The Pharmacokinetics of Ezogabine/Retigabine and the N-acetyl Metabolite of Ezogabine/Retigabine (NAMR) Will Also be Assessed [Phase 1]
This open-label Phase 1 study assessed the pharmacokinetics of digoxin when given with various doses of ezogabine/retigabine in healthy adul…
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CLINICAL_TRIALS trial_result · 2018-06-19Clinical Trial Update: An Open Label, Randomised, Repeat Dose Study to Assess the Pharmacokinetic Performance of Five Ezogabine/Retigabine Modified Release (MR) Formulations at Steady State Compared to the Immediate Release (IR) Formulation. [Phase 1]
This Phase 1 open-label, randomized, repeat-dose study compares five ezogabine/retigabine modified-release formulations to the immediate-rel…
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CLINICAL_TRIALS trial_result · 2018-06-19Clinical Trial Update: Crossover Study to Evaluate the Pharmacokinetics of Ezogabine/Retigabine in Taiwanese Subjects [Phase 1]
A Phase 1 crossover study evaluating the pharmacokinetics of ezogabine/retigabine in Taiwanese subjects has been completed.
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CLINICAL_TRIALS trial_result · 2018-06-19Clinical Trial Update: Effect of Haemodialysis on the Pharmacokinetics of Ezogabine/Retigabine and Its N-acetyl Metabolite [Phase 1]
This completed Phase 1 study assessed the effect of haemodialysis on the pharmacokinetics of ezogabine/retigabine and its N-acetyl metabolit…
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CLINICAL_TRIALS trial_result · 2018-06-06Clinical Trial Update: Open-Label Extension Study of the Phase 3 VRX-RET-E22-302 Double-Blind Trial. 115097 [Phase 3]
Open-label extension study update for a Phase 3 trial investigating a GSK epilepsy program; trial terminated with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-05-23Clinical Trial Update: Epileptic Potentials During Cardiac Surgery and Association With Postoperative Neurological Outcome
A completed clinical trial assessing epileptic potentials during cardiac surgery and their relationship with postoperative neurological outc…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Tele-patient-reported Outcomes (telePRO) in Clinical Practice [NA]
A study evaluating tele-patient-reported outcomes (telePRO) in epilepsy has completed.
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CLINICAL_TRIALS trial_result · 2018-05-14Clinical Trial Update: Radiosurgery or Open Surgery for Epilepsy Trial [NA]
A clinical trial comparing radiosurgery versus open surgery for epilepsy has completed.
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FDA approval · 2018-05-10FDA Approved: BRIVIACT — Supplemental Application (UCB, Inc.)
The FDA approved a supplemental application for BRIVIACT (brivaracetam) submitted by UCB, Inc.
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FDA approval · 2018-05-10FDA Approved: BRIVIACT — Supplemental Application (UCB, Inc.)
FDA approved a supplemental application for Briviact (brivaracetam) submitted by UCB, Inc., which updates the product labeling.
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FDA approval · 2018-05-10FDA Approved: BRIVIACT — Supplemental Application (UCB, Inc.)
FDA approved a supplemental application for BRIVIACT (brivaracetam) submitted by UCB, Inc.
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CLINICAL_TRIALS trial_result · 2018-05-09Clinical Trial Update: Clobazam Use in Epilepsia Partialis Continua - Pilot Study [Phase 3]
A Phase 3 pilot trial evaluating clobazam for Epilepsia Partialis Continua has been terminated.
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CLINICAL_TRIALS trial_result · 2018-05-07Clinical Trial Update: Reduction and Prevention of Seizure Occurrence From Exposure to Auditory Stimulation in Individuals With Neurological Handicaps [NA]
A completed clinical trial evaluated whether exposure to auditory stimulation can reduce or prevent seizures in individuals with neurologica…
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CLINICAL_TRIALS trial_result · 2018-04-30Clinical Trial Update: Effect of Yoga on Mood and Quality of Life in Patients With Refractory Epilepsy [NA]
This completed clinical trial evaluated how yoga affects mood and quality of life in patients with refractory epilepsy, including those with…
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CLINICAL_TRIALS withdrawal · 2018-04-30Clinical Trial Update: Turmeric as Treatment in Epilepsy [NA]
A clinical trial evaluating turmeric as a treatment for epilepsy has been withdrawn, including conditions such as Dravet syndrome, Lennox-Ga…
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CLINICAL_TRIALS trial_result · 2018-04-23Clinical Trial Update: An Open-label, Multinational, Multicenter, Follow-up Study to Evaluate the Long-term Safety and Efficacy of Brivaracetam [Phase 3]
An open-label, multinational Phase 3 follow-up study evaluating the long-term safety and efficacy of brivaracetam in epilepsy; results were …
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CLINICAL_TRIALS research · 2018-04-20Clinical Trial Update: Efficacy of Omega-3 as Adjunctive Therapy for Medically Intractable Epilepsy: A Prospective Open-label Pilot Study [Phase 2]
Phase 2 prospective open-label pilot study evaluating adjunctive omega-3 fatty acids for medically intractable epilepsy; no efficacy results…
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CLINICAL_TRIALS trial_result · 2018-04-19Clinical Trial Update: Stress Management Intervention for Living With Epilepsy (SMILE) [NA]
The SMILE trial evaluating a stress management intervention for people with epilepsy has completed.
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CLINICAL_TRIALS trial_result · 2018-04-18Clinical Trial Update: Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use [Phase 4]
Phase 4 trial update examining how OCT2 and OCTN1 polymorphisms influence gabapentin pharmacokinetics in patients on chronic therapy. The st…
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: In Vivo Imaging of Therapeutic Electric Current Flow
Clinical trial update noting the completed study on in vivo imaging of therapeutic electric current flow, with listed conditions including P…
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CLINICAL_TRIALS research · 2018-04-03Clinical Trial Update: Application of Novel Diagnostic and Therapeutical Methods in Epilepsy and Neurodevelopmental Abnormalities in Children. [NA]
This clinical trial update describes a study from the Medical University of Warsaw investigating novel diagnostic and therapeutic methods fo…
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EMA guidance · 2018-03-23New measures to avoid valproate exposure in pregnancy endorsed
EU endorses new measures to avoid valproate exposure in pregnancy, reinforcing restrictions due to teratogenic risk.
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FDA approval · 2018-03-22FDA Approved: TRILEPTAL — Supplemental Application (Novartis Pharmaceuticals Corporation)
The FDA approved a supplemental application for Trileptal (oxcarbazepine) submitted by Novartis Pharmaceuticals Corporation.
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FDA approval · 2018-03-20FDA Approved: TEGRETOL — Supplemental Application (Novartis Pharmaceuticals Corporation)
The FDA approved a supplemental application for Tegretol (carbamazepine) from Novartis Pharmaceuticals Corporation.