Ependymoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline
A Tata Memorial Centre study is investigating systemic biomarkers to predict radiation-induced neurocognitive decline in patients with brain…
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CLINICAL_TRIALS trial_result · 2025-04-08Clinical Trial Update: Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Patients With Recurrent Posterior Fossa Ependymoma [Phase 1]
Phase 1 study assessing intraventricular infusion of 5-azacytidine for recurrent posterior fossa ependymoma has completed.
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and Gliomas
This clinical trial update outlines an integrated analysis of how embryonal tumors and gliomas respond to therapy and develop resistance, in…
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CLINICAL_TRIALS trial_result · 2025-03-03Clinical Trial Update: Combination Intraventricular Chemotherapy Pilot Study: 5-Azacytidine (5-AZA) and Trastuzumab Infusions Into the Fourth Ventricle or Resection Cavity in Children and Adults with Recurrent or Residual Posterior Fossa Ependymoma [EARLY_Phase 1]
Early-phase study evaluating intraventricular combination therapy with azacitidine and trastuzumab for recurrent or residual posterior fossa…
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CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine [Phase 1]
A Phase 1 trial of the Heat Shock Protein Peptide Complex-96 (HSPPC-96) vaccine for glioblastoma and related CNS tumors was terminated. The …
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology
Update on the ProTRAIT proton therapy research infrastructure in neuro-oncology, with ongoing recruitment for several brain tumor conditions…
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CLINICAL_TRIALS trial_result · 2024-11-12Clinical Trial Update: A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma [Phase 2]
Phase 2 trial from St. Jude evaluating surgery followed by fractionated re-irradiation for recurrent ependymoma; results posted on 2024-11-1…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Phase I Study of APX005M in Pediatric Central Nervous System Tumors [Phase 1]
Phase I study of APX005M in pediatric central nervous system tumors; the trial is active but not recruiting and results have been posted. Sp…
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CLINICAL_TRIALS withdrawal · 2024-10-09Clinical Trial Update: StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord [Phase 1]
Phase 1 trial evaluating StrataXRT to prevent radiation dermatitis in pediatric patients undergoing brain or spinal irradiation has been wit…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 update on erdafitinib for FGFR-mutant relapsed or refractory pediatric cancers enrolled in the Pediatric MATCH trial; results were p…
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CLINICAL_TRIALS research · 2024-07-12Clinical Trial Update: In Vitro Models From Pediatric Brain Tumors
The update describes a study focused on developing in vitro models of pediatric brain tumors, including malignant glioma, ependymoma, and me…
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CLINICAL_TRIALS research · 2024-07-03Clinical Trial Update: Axitinib and Oral Metronomic Etoposide for Pediatric Children and AYA Refractory/Relapsing Medulloblastoma and Ependymoma [Phase 1, Phase 2]
A Phase 1/2 trial of axitinib combined with oral metronomic etoposide for pediatric and adolescent/young adult patients with relapsed/refrac…
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CLINICAL_TRIALS trial_result · 2024-05-31Clinical Trial Update: SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors [Phase 1]
The SJDAWN Phase 1 trial at St. Jude evaluated molecularly-driven doublet therapies for children and young adults with recurrent brain tumor…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: Everolimus for Children With Recurrent or Progressive Ependymoma [Phase 2]
Everolimus was studied in a Phase 2 trial for children with recurrent or progressive ependymoma. The study is completed and results were pos…
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CLINICAL_TRIALS research · 2024-04-26Clinical Trial Update: An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma [Phase 2, Phase 3]
International clinical program for the diagnosis and treatment of childhood ependymoma is in Phase 2/3 and currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-04-24Clinical Trial Update: Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating palbociclib in relapsed or refractory pediatric tumors with activating alterations in cell cycle ge…
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CLINICAL_TRIALS trial_result · 2024-04-08Clinical Trial Update: Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children [Phase 1]
Phase 1b trial update for PVSRIPO in recurrent malignant glioma in children has completed enrollment and results posted.
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CLINICAL_TRIALS trial_result · 2024-04-05Clinical Trial Update: Molecular-Guided Therapy for Childhood Cancer [NA]
A completed clinical trial evaluating molecular-guided therapy for several childhood cancers, with results posted in April 2024.
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CLINICAL_TRIALS trial_result · 2023-09-13Clinical Trial Update: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
This Phase 2 Pediatric MATCH trial evaluated vemurafenib in children with BRAF V600-mutant relapsed or refractory advanced solid tumors, non…
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CLINICAL_TRIALS trial_result · 2023-07-13Clinical Trial Update: Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors [Phase 2]
A Phase 2 clinical trial evaluated memantine for preventing cognitive late effects in pediatric patients undergoing cranial radiation therap…
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CLINICAL_TRIALS trial_result · 2023-05-16Clinical Trial Update: Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 Pediatric MATCH trial evaluating Ulixertinib for MAPK-pathway-mutant tumors in children, including advanced solid tumors, Non-Hodgki…
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CLINICAL_TRIALS trial_result · 2023-03-24Clinical Trial Update: A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer [Phase 1, Phase 2]
A phase 1/2 trial evaluating bempegaldesleukin (BEMPEG) in combination with nivolumab in pediatric and young adult patients with recurrent o…
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CLINICAL_TRIALS trial_result · 2023-03-02Clinical Trial Update: Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma [Phase 3]
A Phase 3 trial comparing maintenance chemotherapy versus observation after induction chemotherapy and radiation for newly diagnosed ependym…
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CLINICAL_TRIALS trial_result · 2021-12-28Clinical Trial Update: Carboplatin and Bevacizumab for Recurrent Ependymoma [Phase 2]
Phase 2 trial of carboplatin plus bevacizumab for recurrent ependymoma has completed, and results have been posted. The study evaluated effi…
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CLINICAL_TRIALS trial_result · 2021-11-30Clinical Trial Update: Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma [Phase 2]
Phase 2 trial of marizomib for recurrent ependymoma in various locations was terminated; results posted in 2021.