Egfr-mutant Non-small Cell Lung Cancer
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Efficacy and Safety of SKB264 Plus Anlotinib in EGFR-TKI-Resistant Advanced NSCLC With Liver Metastasis [Phase 2]
A Phase 2 clinical trial evaluating the combination of SKB264 and Anlotinib for EGFR-TKI-resistant advanced non-small cell lung cancer with …
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: A Study to Investigate Safety, Tolerability, PK and Anti-tumor Activity of TRX-221 in EGFRm NSCLC Patients [Phase 1, Phase 2]
A Phase 1/2 trial of TRX-221 in EGFR-mutant non-small cell lung cancer has been terminated; the update covers safety, tolerability, pharmaco…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: OSIREAL - Osimertinib RWE on EGFRm NSCLC in Spain
This entry reports the OSIREAL real-world evidence trial of Osimertinib for EGFR-mutant non-small cell lung cancer in Spain, sponsored by As…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Firmonertinib 160 mg in Patients With EGFR-Mutant Advanced NSCLC Demonstrating SD After 8 Week Induction With Firmonertinib 80 mg [Phase 2]
Phase 2 trial of Firmonertinib in EGFR-mutant advanced non-small cell lung cancer shows disease stabilization after an 8-week induction with…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Study of EGF816 in Combination With Selected Targeted Agents in EGFR-mutant NSCLC [Phase 1]
A Phase 1 trial evaluating EGF816 in combination with selected targeted agents for EGFR-mutant non-small cell lung cancer; the study is curr…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Neoadjuvant Sacituzumab Tirumotecan and Limertinib for Potentially Resectable Stage Ⅲ EGFR-mutant Non-small Cell Lung Cancer [Phase 2]
A Phase 2 neoadjuvant trial is investigating sacituzumab tirumotecan with limertinib for potentially resectable stage III EGFR-mutant non-sm…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Special Investigation for VIZIMPRO Tablets (Secondary Data Collection Study; Safety and Efficacy of VIZIMPRO Under Japanese Medical Practice)
A completed special investigation collecting safety and efficacy data for VIZIMPRO (dacomitinib) in EGFR mutation-positive non-small cell lu…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC [Phase 1, Phase 2]
This document describes a Phase 1/2 clinical trial evaluating the safety, tolerability, and pharmacokinetics of JIN-A02 in patients with EGF…
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: Neo-DIANA: Neoadjuvant Treatment for EGFR Mutated Patients [Phase 2]
A Phase 2 neoadjuvant trial for EGFR-mutated non-small cell lung cancer (Neo-DIANA) was terminated, with results posted in 2025.
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CLINICAL_TRIALS trial_result · 2024-12-13Clinical Trial Update: Assessing the Effect of DZD9008 on the Pharmacokinetics of the Cocktail Probes Representative for CYP3A4, P-gp, BCRP and OATP1B1 in Patients with EGFR or HER2 Mutant Advanced Non-small Cell Lung Cancer (WU-KONG19) [Phase 1]
Phase 1 trial update evaluating how DZD9008 influences the pharmacokinetics of cocktail probe drugs reflecting CYP3A4, P-gp, BCRP, and OATP1…
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CLINICAL_TRIALS research · 2024-08-16Clinical Trial Update: CSF CTC-Capture-Guided EGFR-TKI and Bevacizumab Combination Therapy in EGFR-Mutant Advanced NSCLC [EARLY_Phase 1]
An early-phase (Phase 1) clinical trial update evaluating a CSF CTC-capture-guided combination of EGFR-TKI and bevacizumab in EGFR-mutant ad…
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CLINICAL_TRIALS trial_result · 2024-06-20Clinical Trial Update: A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants [Phase 1]
Phase 1 study evaluating how itraconazole and carbamazepine affect BAY2927088 blood levels in healthy participants; study completed.
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CLINICAL_TRIALS trial_result · 2024-06-17Clinical Trial Update: Phase II Trial of Almonertinib Plus Lastet for EGFR+ Non-small Cell Lung Cancer [Phase 2]
A Phase II trial investigating Almonertinib in combination with Lastet for EGFR-positive non-small cell lung cancer; the study is not yet re…
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CLINICAL_TRIALS trial_result · 2023-09-01Clinical Trial Update: A Study of Lazertinib as Consolidation Therapy in Patients With Locally Advanced, Unresectable, EGFR-Mutant Non-Small Cell Lung Cancer (Stage III) Following Chemoradiation Therapy [Phase 2]
Phase 2 trial evaluating lazertinib as consolidation therapy after chemoradiation in locally advanced, unresectable EGFR-mutant non-small ce…
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CLINICAL_TRIALS trial_result · 2022-06-22Clinical Trial Update: Erlotinib Hydrochloride and Onalespib Lactate in Treating Patients With Recurrent or Metastatic EGFR-Mutant Non-small Cell Lung Cancer [Phase 1, Phase 2]
This clinical trial update reports results from a Phase 1/2 study of erlotinib hydrochloride combined with onalespib lactate in patients wit…