Early-onset Alzheimer Disease
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Genetics of Mendelian Forms of Young Onset Alzheimer Disease [NA]
A completed clinical trial investigating the genetics of Mendelian (autosomal dominant) forms of young-onset Alzheimer's disease. The study …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
This clinical trial update describes the development of a database to study digital and blood-based biomarkers and their relationship to tau…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study [NA]
Mayo Clinic is conducting a longitudinal imaging study on Alzheimer's-related disorders, including atypical Alzheimer's disease and logopeni…
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD [Phase 1]
A Phase 1 trial is evaluating the safety and tolerability of ALN-APP in patients with Early-Onset Alzheimer Disease. The study is currently …
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease [NA]
A recruiting clinical trial called the MIMA Pilot Study investigating microstructure of the medial temporal lobe in early Alzheimer disease.
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CLINICAL_TRIALS trial_result · 2025-10-20Clinical Trial Update: Gene Therapy for APOE4 Homozygote of Alzheimer's Disease [Phase 1, Phase 2]
Update on a Phase 1/2 gene therapy trial for APOE4 homozygous Alzheimer's disease by Lexeo Therapeutics; the study has completed.
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CLINICAL_TRIALS trial_result · 2025-05-11Clinical Trial Update: Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau [Phase 1]
Phase 1 study examining neuronavigation-guided focused ultrasound–induced opening of the blood-brain barrier in early-onset Alzheimer's dise…
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CLINICAL_TRIALS research · 2024-07-30Clinical Trial Update: MECHANISMS OF NEURONAL RESILIENCE IN ALZHEIMER'S DISEASE AND ITS FOCAL VARIANTS: A PET/MR STUDY [NA]
This entry describes an ongoing PET/MR study investigating mechanisms of neuronal resilience in Alzheimer's disease and its focal variants, …
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CLINICAL_TRIALS trial_result · 2016-08-11Clinical Trial Update: Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
A clinical trial evaluating sleep apnea in early- to mid-stage Alzheimer's disease has been terminated. The study was sponsored by Centre Ho…