Diffuse Midline Glioma

• CLINICAL_TRIALS research · 2026-03-24
  Clinical Trial Update: Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis [Phase 1]

  Phase 1 clinical trial evaluating intratumoral microdialysis to characterize abemaciclib neuropharmacokinetics in diffuse midline glioma.

• CLINICAL_TRIALS research · 2026-03-17
  Clinical Trial Update: ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors [Phase 1]

  Phase 1 clinical trial evaluating ONC206 for newly diagnosed and recurrent diffuse midline gliomas and other recurrent malignant CNS tumors;…

• CLINICAL_TRIALS research · 2026-03-12
  Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma [Phase 1]

  A Phase 1 trial evaluating the addition of AZD1390 to radiation therapy for newly diagnosed pediatric high-grade gliomas, including diffuse …

• CLINICAL_TRIALS research · 2026-03-10
  Clinical Trial Update: PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma [Phase 1, Phase 2]

  This clinical trial update describes a phase 1/2 study of PEP-CMV in combination with nivolumab for newly diagnosed and recurrent diffuse mi…

• CLINICAL_TRIALS research · 2026-03-06
  Clinical Trial Update: A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG) [Phase 1]

  This is a Phase 1 clinical trial update for the investigational drug FZ-AD005 in patients with high-grade glioma, including diffuse midline …

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• CLINICAL_TRIALS research · 2026-02-25
  Clinical Trial Update: Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation [Phase 1]

  Phase 1 clinical trial update for HSV-1 M032 in children and adults with newly diagnosed diffuse midline glioma after standard radiation; st…

• CLINICAL_TRIALS research · 2026-01-09
  Clinical Trial Update: Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor [Phase 1]

  This clinical trial update describes a Phase 1 study of gallium maltolate for relapsed or refractory pediatric high-grade glioma and atypica…

• CLINICAL_TRIALS research · 2025-11-20
  Clinical Trial Update: Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors [Phase 1]

  This Phase 1 clinical trial update describes a Quad CAR T cell therapy targeting B7-H3, EGFR806, HER2, and IL13-Zetakine for pediatric diffu…

• CLINICAL_TRIALS research · 2025-10-20
  Clinical Trial Update: International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

  An international DIPG/DMG Registry and Repository study is currently recruiting to collect data and biospecimens for diffuse intrinsic ponti…

• CLINICAL_TRIALS research · 2025-07-08
  Clinical Trial Update: Phase II Exploratory Study of Sequential Triple Therapy (Temozolomide/Anlotinib/Bemarituzumab) in Combination With Concurrent Radiotherapy With Temozolomide and Anlotinib for the Maintenance Treatment of Diffuse Midline Gliomas in Children

  A Phase II exploratory trial evaluating sequential triple therapy with temozolomide, anlotinib, and bemarituzumab plus concurrent radiothera…

• CLINICAL_TRIALS research · 2025-06-26
  Clinical Trial Update: Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma [Phase 1]

  Phase 1 clinical trial update evaluating intrathecal azacitidine in combination with nivolumab for recurrent high-grade glioma. The study is…

• CLINICAL_TRIALS research · 2025-02-05
  Clinical Trial Update: GD2-CAR T Cells for Pediatric Brain Tumours [Phase 1]

  Phase 1 trial evaluating GD2-CAR T cells for pediatric brain tumors is currently recruiting. The study targets medulloblastoma, embryonal tu…

• CLINICAL_TRIALS research · 2024-04-30
  Clinical Trial Update: xPedite: A Study to Expedite DIPG and DMG Research

  The sponsor xCures reports a clinical trial called xPedite to expedite DIPG and DMG research. The study is currently recruiting.