Cutaneous Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer [Phase 3]
A Phase 3 trial is evaluating adding cemiplimab to surgery versus surgery alone for advanced eyelid and other cutaneous squamous cell carcin…
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System [Phase 2]
Phase 2 clinical trial update examining amivantamab with hyaluronidase or cetuximab for advanced cutaneous squamous cell carcinoma in people…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 study of TransCon TLR7/8 agonist with or without pembrolizumab in patients with advanced or metastatic solid tumors has been ter…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007) [Phase 2, Phase 3]
A phase 2/3 study of Intismeran Autogene (V940) in combination with pembrolizumab for cutaneous squamous cell carcinoma (V940-007) has compl…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Neoadjuvant PD-1 Inhibitor and EGFR Inhibitor in Locally Advanced Cutaneous Squamous Cell Carcinoma [Phase 2]
This clinical trial update describes a Phase 2 neoadjuvant study combining a PD-1 inhibitor with an EGFR inhibitor for locally advanced cuta…
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010) [Phase 2]
Phase 2 study MK-4280A-010 evaluating favezelimab coformulated with pembrolizumab in selected solid tumors has completed.
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications [Phase 1]
A Phase 1 clinical trial update describes evaluation of BBI-355 (CHK1 inhibitor) in combination with BBI-825 (RNR inhibitor) for tumors with…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Intralesional Cemiplimab for Adult Patients With Cutaneous Squamous Cell Carcinoma or Basal Cell Carcinoma [Phase 1]
Phase 1 clinical trial update of intralesional cemiplimab in adults with cutaneous squamous cell carcinoma or basal cell carcinoma has compl…
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CLINICAL_TRIALS trial_result · 2026-01-06Clinical Trial Update: Decisional Conflicts, Health-related QoL and Satisfaction With Care in High-risk cSCC in the Head-neck Region
A completed clinical trial evaluated decisional conflicts, health-related quality of life, and satisfaction with care for patients with high…
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer [Phase 2]
A Phase 2 trial evaluating Vidutolimod in combination with cemiplimab for adults with advanced or metastatic cancers was terminated, with re…
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma [Phase 1]
The document describes a Phase 1 neoadjuvant trial of cemiplimab (Libtayo) for Merkel cell carcinoma and locoregionally advanced cutaneous s…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer [Phase 1]
Phase 1 clinical trial evaluating MQ710 with and without pembrolizumab in solid tumors; the study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors [Phase 2]
Phase 2 study evaluating SOT101 in combination with pembrolizumab in selected advanced solid tumors was terminated; results have been posted…
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CLINICAL_TRIALS trial_result · 2025-10-22Clinical Trial Update: High-Risk Skin Cancers With Atezolizumab Plus NT-I7 [Phase 1, Phase 2]
A terminated Phase 1/2 trial evaluating the combination of atezolizumab and NT-I7 for high-risk skin cancers (melanoma, Merkel cell carcinom…
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CLINICAL_TRIALS trial_result · 2025-10-16Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors [Phase 1]
Phase 1 clinical trial of INCB099318 in participants with advanced solid tumors has been terminated. The update reports safety, tolerability…
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CLINICAL_TRIALS trial_result · 2025-10-15Clinical Trial Update: CemiplimAb Survivorship Epidemiology
Completed clinical trial studying survivorship epidemiology for cemiplimab in skin cancers, including cutaneous squamous cell carcinoma and …
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: Topical Sirolimus in Chemoprevention of Facial Squamous Cell Carcinomas in Solid Organ Transplant Recipients (SiroSkin) [Phase 3]
This entry reports a Phase 3 clinical trial (SiroSkin) evaluating topical sirolimus for chemoprevention of facial cutaneous squamous cell ca…
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CLINICAL_TRIALS trial_result · 2025-08-11Clinical Trial Update: Neo-adjuvant Nivolumab or Nivolumab With Ipilimumab in Advanced Cutaneous Squamous Cell Carcinoma Prior to Surgery [Phase 2]
This clinical trial update reports the completion of a Phase 2 study evaluating neoadjuvant nivolumab, with or without ipilimumab, in patien…
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer [Phase 2]
Phase 2 clinical trial evaluating the combination of radiation therapy and cemiplimab for cutaneous squamous cell carcinoma, including local…
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CLINICAL_TRIALS trial_result · 2025-07-22Clinical Trial Update: Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630) [Phase 3]
A Phase 3 trial (MK-3475-630/KEYNOTE-630) evaluating pembrolizumab versus placebo after surgery and radiation in locally advanced cutaneous …
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors [Phase 1]
This Phase 1 trial reports on the safety, tolerability, pharmacokinetics, and pharmacodynamics of INCB099280 in participants with advanced s…
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: The UNSCARRed Study: UNresctable Squamous Cell Carcinoma Treated With Avelumab and Radical Radiotherapy [Phase 2]
Phase 2 study of Avelumab with radical radiotherapy in unresectable cutaneous squamous cell carcinoma was terminated.
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Neoadjuvant Study of PD-1 Inhibitor Pembrolizumab in PD-1 Naive Cutaneous Squamous Cell Carcinoma (cSCC) [Phase 2]
Phase 2 neoadjuvant trial of pembrolizumab in PD-1-naive cutaneous squamous cell carcinoma. Results have been posted in May 2025.
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma [Phase 1]
This clinical trial update reports completion of a Phase 1 study evaluating lenvatinib in combination with cetuximab in patients with advanc…
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CLINICAL_TRIALS trial_result · 2025-04-23Clinical Trial Update: Study of TBio-6517 Given Alone or in Combination With Pembrolizumab in Solid Tumors [Phase 1]
Phase 1 study of TBio-6517 alone or in combination with pembrolizumab in solid tumors was terminated.