Colorectal Cancer

• CLINICAL_TRIALS trial_result · 2025-05-01
  Clinical Trial Update: MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01) [Phase 1, Phase 2]

  A completed Phase 1/2 trial (C-PRECISE-01) evaluated MEN1611 with cetuximab in metastatic colorectal cancer; results have been posted.

• CLINICAL_TRIALS research · 2025-05-01
  Clinical Trial Update: Survival Monitoring in Russian Cancer Registries

  An update on an active-not-recruiting clinical trial from N.N. Petrov National Medical Research Center of Oncology focusing on monitoring su…

• CLINICAL_TRIALS research · 2025-05-01
  Clinical Trial Update: Registry Platform Colorectal Cancer

  An update on a registry-based clinical trial for colorectal cancer showing the study is active but not recruiting.

• CLINICAL_TRIALS research · 2025-04-30
  Clinical Trial Update: Prognostic Value of Neurometabolic Networks in CRC (PVNM-CRC)

  A clinical trial update describes a study on the prognostic value of neurometabolic networks in colorectal cancer (PVNM-CRC), which is curre…

• CLINICAL_TRIALS research · 2025-04-30
  Clinical Trial Update: Circulating Tumor DNA in Patients Summoned for Colonoscopy; - a Liquid Biopsy for Detection, Characterization, Individualized Treatment and Follow-up of Colorectal Cancer

  This clinical study investigates using circulating tumor DNA (a liquid biopsy) in patients scheduled for colonoscopy to aid detection, chara…

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• CLINICAL_TRIALS research · 2025-04-30
  Clinical Trial Update: The Impact of Laparotomy and Analgesia Methods on Diaphragm

  Clinical trial update on how different laparotomy and analgesia methods affect diaphragmatic function in patients with colorectal neoplasms …

• CLINICAL_TRIALS trial_result · 2025-04-30
  Clinical Trial Update: Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population

  This completion update reports on a study investigating how autophagy-related genes, long noncoding RNAs, and SNPs relate to colorectal canc…

• CLINICAL_TRIALS research · 2025-04-30
  Clinical Trial Update: Evaluation of the Effect of Adapted Physical Activity on the Modification of Lipid Metabolism During Chemotherapy for Metastatic COLorectal Cancer [Phase 2]

  A Phase 2 clinical trial evaluating whether adapted physical activity can modify lipid metabolism during chemotherapy in patients with metas…

• CLINICAL_TRIALS trial_result · 2025-04-29
  Clinical Trial Update: Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 [Phase 2]

  Phase 2 trial of ponsegromab in cancer patients with cachexia and elevated GDF-15 completed; results posted.

• CLINICAL_TRIALS research · 2025-04-29
  Clinical Trial Update: Low Versus Standard Intraabdominal Pressure in Robot-assisted Colorectal Cancer Surgery [NA]

  A clinical trial evaluating low versus standard intraabdominal pressure during robot-assisted colorectal cancer surgery is currently recruit…

• CLINICAL_TRIALS research · 2025-04-29
  Clinical Trial Update: To Evaluate the Tolerability and Pharmacokinetics of TQB2101 for Injection in Patients With Advanced Malignant Tumors [Phase 1]

  Phase 1 trial to evaluate tolerability and pharmacokinetics of TQB2101 in patients with advanced malignant tumors; the study is not yet recr…

• CLINICAL_TRIALS research · 2025-04-27
  Clinical Trial Update: HBM4003 Combine With Toripalimab in Patients With Advanced NEN and Other Solid Tumors Study [Phase 1]

  Phase 1 study evaluating HBM4003 in combination with toripalimab in patients with advanced neuroendocrine tumors and other solid tumors, inc…

• CLINICAL_TRIALS research · 2025-04-27
  Clinical Trial Update: Exploratory Clinical Study of Claudin18.2-Targeted CAR-DC and CAR-T Therapy in Advanced Colorectal Cancer [Phase 1]

  Phase 1 exploratory clinical study evaluating Claudin18.2-targeted CAR-DC and CAR-T therapy for advanced colorectal cancer is currently recr…

• CLINICAL_TRIALS research · 2025-04-27
  Clinical Trial Update: Exploration of the Dynamic Changes and Mechanisms of the Immune Microenvironment in Advanced Colorectal Cancer Treated With IBI363 Combination Therapy

  A clinical trial investigating dynamic changes and mechanisms of the immune microenvironment in advanced colorectal cancer treated with IBI3…

• CLINICAL_TRIALS research · 2025-04-27
  Clinical Trial Update: SBRT-LDRT-Cadonilimab for Advanced Gastric, Colorectal and Ovarian Cancers With Peritoneal Metastases [Phase 1, Phase 2]

  A Phase 1/Phase 2 clinical trial evaluating SBRT-LDRT with cadonilimab for advanced gastric, colorectal, and ovarian cancers with peritoneal…

• CLINICAL_TRIALS research · 2025-04-27
  Clinical Trial Update: Normobaric Oxygen Therapy in Colorectal Cancer Patients [NA]

  This clinical trial update indicates a not-yet-recruiting study evaluating normobaric oxygen therapy in colorectal cancer patients, conducte…

• CLINICAL_TRIALS trial_result · 2025-04-25
  Clinical Trial Update: A Study of BLYG8824A in Participants With Locally Advanced or Metastatic Colorectal Cancer [Phase 1]

  Phase 1 study of the investigational agent BLYG8824A in locally advanced or metastatic colorectal cancer has completed. The trial was sponso…

• CLINICAL_TRIALS research · 2025-04-25
  Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression [Phase 1, Phase 2]

  A2 Biotherapeutics is evaluating A2B530, a logic-gated CAR T therapy, in Phase 1/2 trials for CEA-expressing solid tumors that have lost HLA…

• CLINICAL_TRIALS research · 2025-04-24
  Clinical Trial Update: Detecting Colorectal Cancer With Liver Metastatic Lesions Using Novel Precise Imaging Tools [Phase 1]

  Phase 1 clinical trial update evaluating novel imaging tools for detecting colorectal cancer with liver metastases; not yet recruiting.

• CLINICAL_TRIALS research · 2025-04-24
  Clinical Trial Update: The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors [Phase 1]

  Phase 1 trial update studying the immune effects of a fermented wheat germ extract added to standard checkpoint inhibitor therapy in patient…

• CLINICAL_TRIALS research · 2025-04-24
  Clinical Trial Update: A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α SrRNA in Treating Metastatic CRC Patients [EARLY_Phase 1]

  An early-phase 1 clinical trial is evaluating intravenous HNF4α siRNA for safety and efficacy in patients with metastatic colorectal cancer …

• CLINICAL_TRIALS research · 2025-04-24
  Clinical Trial Update: Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis

  A clinical trial is evaluating a Raman spectroscopy-based deep learning model for early cancer diagnosis; recruitment is ongoing. The study …

• CLINICAL_TRIALS research · 2025-04-23
  Clinical Trial Update: DEBIRI Plus Chemotherapy vs. Chemotherapy Alone in Colorectal Cancer Liver Metastases [Phase 3]

  Phase 3 trial comparing DEBIRI (irinotecan-eluting beads) plus standard chemotherapy versus chemotherapy alone in colorectal cancer liver me…

• CLINICAL_TRIALS trial_result · 2025-04-23
  Clinical Trial Update: Study of TBio-6517 Given Alone or in Combination With Pembrolizumab in Solid Tumors [Phase 1]

  Phase 1 study of TBio-6517 alone or in combination with pembrolizumab in solid tumors was terminated.

• CLINICAL_TRIALS trial_result · 2025-04-23
  Clinical Trial Update: A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment [Phase 1, Phase 2]

  NuCana plc released results from an early-phase safety, pharmacokinetic, and efficacy study of NUC-3373 in combination with standard colorec…