Colorectal Cancer
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer [Phase 2]
This document describes a Phase II clinical trial of Ivonescimab, an anti-PD-1/VEGF bispecific antibody, in patients with previously treated…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: A Phase II Clinical Study of Aipalolitovorelizumab (QL1706) Combined With Fruquintinib in the Treatment of Immunodominant pMMR/MSS Metastatic Colorectal Cancer That Has Failed Second-line or Above Treatment [Phase 2]
Phase II clinical trial evaluating Aipalolitovorelizumab (QL1706) plus Fruquintinib for immunodominant pMMR/MSS metastatic colorectal cancer…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups [NA]
A clinical trial update describing an implementation research study aimed at increasing colorectal cancer screening rates among low-income a…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Eliminating Barriers to Colorectal Cancer Screening Using Rapid Cycle Testing: A Pilot Study [NA]
This clinical trial update describes a pilot study from Massachusetts General Hospital testing rapid cycle testing to reduce barriers to col…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC) [Phase 1]
A Phase 1 study evaluating the safety and efficacy of RGT-61159 in adults with relapsed or refractory Adenoid Cystic Carcinoma or Colorectal…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment [Phase 4]
Phase 4 clinical trial update examining DPYD pharmacogenomics for fluoropyrimidine dose-adjustment; currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-11-13Clinical Trial Update: Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer [Phase 1]
This Phase 1 trial evaluates the safety, pharmacokinetics, and activity of GDC-1971 in combination with osimertinib for unresectable, locall…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study
Clinical trial update announcing recruitment for the MiRDA-C study investigating minimal residual disease in colorectal cancer across multip…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome [Phase 2]
A Phase IIa randomized, double-blind trial comparing naproxen to aspirin for cancer immune interception in Lynch syndrome, with a focus on c…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Positive Fit to Colonoscopy: Closing the Gap
Ongoing clinical trial from Massachusetts General Hospital recruiting participants for a study on colorectal cancer screening, aiming to imp…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Role of Diet on the Microbiome of the Digestive System
This clinical trial update describes a study evaluating how dietary interventions affect the gut microbiome in colorectal cancer patients, w…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: CRC Screening in Unscreened Individuals 45-54
A clinical trial evaluating colorectal cancer screening in unscreened individuals aged 45-54 is currently recruiting, led by Massachusetts G…
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FDA approval · 2025-11-12FDA Tentative Approval: FLUOROURACIL — Supplemental Application (Gland Pharma Limited)
FDA Tentative Approval for Fluorouracil from Gland Pharma Limited under an ANDA, indicating a pathway to U.S. market subject to regulatory t…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer [Phase 1]
A Phase 1 trial evaluating natural killer cell therapy in combination with Interleukin-2 and the TGF-beta receptor I inhibitor vactosertib f…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: An Observational Study Called STAR-T to Learn More About the Sequential Treatment With Regorafenib and TAS-102 in Adults With Metastatic Colorectal Cancer Under Real World Conditions
An observational study (STAR-T) assessed sequential treatment with regorafenib followed by TAS-102 in adults with metastatic colorectal canc…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS [Phase 1, Phase 2]
A Phase 1/Phase 2 study evaluating RMC-6236 in patients with advanced solid tumors harboring RAS mutations, including non-small cell lung ca…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors [Phase 1, Phase 2]
Phase I/II trial of autologous T cells engineered to express T-cell receptors (TCRs) in patients with solid tumors was terminated with resul…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer [Phase 1, Phase 2]
A ClinicalTrials.gov entry describes the 3B-FOLFOX study, a Phase 1/2 trial of FOLFOX and Bevacizumab combined with Botensilimab and Balstil…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: A Prospective Feasibility Study Using ctDNA to Tailor Neoadjuvant Chemotherapy for Patients With Colorectal or Appendiceal Adenocarcinoma [NA]
A prospective feasibility study at MD Anderson to use circulating tumor DNA to tailor neoadjuvant chemotherapy for patients with colorectal …
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Amplitude-Modulated Radiofrequency Electromagnetic Fields (AM RF EMF) in Combination With Fruquintinib in Refractory Metastatic Colorectal Cancer [Phase 2]
A Phase 2 clinical trial is evaluating the combination of amplitude-modulated radiofrequency electromagnetic fields (AM RF EMF) with Fruquin…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) [NA]
This clinical trial update concerns the CONFIRM study comparing colonoscopy versus fecal immunochemical testing for reducing mortality from …
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Collection of Samples USOPTIVAL Study
The update reports ongoing recruitment for the USOPTIVAL study collecting samples, sponsored by Universal Diagnostics. The study targets col…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Informed Choice - Compass
A terminated clinical trial update regarding Exact Sciences' Informed Choice - Compass related to colorectal cancer.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation
A prospective, multi-center observational study is evaluating the Signal-C Test for colorectal cancer, including advanced adenocarcinoma, an…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer
An ongoing clinical trial from City of Hope Medical Center exploring a splicing-based predictive learning method to personalize chemotherapy…