Colorectal Cancer

• CLINICAL_TRIALS trial_result · 2023-12-07
  Clinical Trial Update: A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors [Phase 1, Phase 2]

  Results from a Phase 1/2 study of INCB001158 in combination with chemotherapy for solid tumors, including biliary tract cancer and colorecta…

• CLINICAL_TRIALS trial_result · 2023-12-07
  Clinical Trial Update: RC48 Plus Tislelizumab, Low-dose Capecitabine and Celecoxib for HER2-positive Metastatic Colorectal Cancer [Phase 2]

  Phase 2 trial update evaluating RC48 plus tislelizumab, low-dose capecitabine, and celecoxib for HER2-positive metastatic colorectal cancer.

• CLINICAL_TRIALS trial_result · 2023-12-07
  Clinical Trial Update: Transversus Abdominis Plane Blocks With and Without Dexamethasone [Phase 1, Phase 2]

  A clinical trial update on transversus abdominis plane blocks with and without dexamethasone across Phase 1 and Phase 2 stages, with unclear…

• CLINICAL_TRIALS research · 2023-12-07
  Clinical Trial Update: Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery [Phase 4]

  A Phase 4 clinical trial assessing how opioid analgesia influences circulating tumor cells in open colorectal cancer surgery has completed.

• CLINICAL_TRIALS research · 2023-12-07
  Clinical Trial Update: Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery [Phase 4]

  A Phase 4 clinical trial examining how opioid analgesia affects circulating tumor cells in patients undergoing laparoscopic colorectal cance…

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• CLINICAL_TRIALS trial_result · 2023-12-05
  Clinical Trial Update: Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia [NA]

  A completed clinical trial assessing audio and video brochures to increase colorectal cancer screening among adults in Appalachia.

• CLINICAL_TRIALS trial_result · 2023-12-01
  Clinical Trial Update: Evaluation of Tumour Growth and Oncological Treatment in Patients With CRLM Using Zebra Fish Embryo Model [Phase 1, Phase 2]

  Early-phase trial evaluating tumor growth and oncological treatment in colorectal liver metastases using a zebra fish embryo model.

• FDA approval · 2023-11-28
  FDA Approved: OXALIPLATIN — Supplemental Application (Sandoz Inc)

  FDA approved a supplemental application for oxaliplatin submitted by Sandoz Inc., approving a generic version of the chemotherapy drug. The …

• CLINICAL_TRIALS trial_result · 2023-11-18
  Clinical Trial Update: Bemalenograstim Alfa for the Prevention in Patients With Colorectal Cancer/Pancreatic Cancer [Phase 2]

  A Phase 2 clinical trial update for Bemalenograstim Alfa in preventing outcomes for patients with colorectal or pancreatic cancer; status is…

• CLINICAL_TRIALS trial_result · 2023-11-18
  Clinical Trial Update: Sulfasalazine in Patients With Metastatic Colorectal Cancer [Phase 3]

  Phase 3 clinical trial investigating sulfasalazine for metastatic colorectal cancer is currently recruiting.

• CLINICAL_TRIALS trial_result · 2023-11-15
  Clinical Trial Update: Cadonilimab Plus FOLFOXIRI and Bevacizumab as First Line Therapy for Metastatic MSS Colorectal Cancer [Phase 2]

  Phase 2 trial update evaluating cadonilimab in combination with FOLFOXIRI and bevacizumab as first-line therapy for metastatic MSS colorecta…

• CLINICAL_TRIALS trial_result · 2023-11-15
  Clinical Trial Update: COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC [Phase 1, Phase 2]

  Phase 1/2 clinical trial in metastatic microsatellite-stable colorectal cancer evaluating novel oncology therapies in combination with chemo…

• CLINICAL_TRIALS trial_result · 2023-11-14
  Clinical Trial Update: Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers [Phase 2]

  This Phase II trial evaluates a combination immunotherapy for advanced small intestine cancer (small bowel) and colorectal cancer; the study…

• CLINICAL_TRIALS trial_result · 2023-11-14
  Clinical Trial Update: FOLFOXIRI Plus Cetuximab vs. FOLFOXIRI Plus Bevacizumab 1st-line in BRAF-mutated mCRC [Phase 2]

  Phase 2 trial comparing FOLFOXIRI + cetuximab versus FOLFOXIRI + bevacizumab in first-line treatment of BRAF-mutated metastatic colorectal c…

• CLINICAL_TRIALS trial_result · 2023-11-09
  Clinical Trial Update: To Determine the Safety of Regorafenib, Hydroxychloroquine, and Entinostat Metastatic Colorectal Cancer [Phase 1]

  Phase 1 trial update assessing safety of regorafenib, hydroxychloroquine, and entinostat in metastatic colorectal cancer has completed with …

• FDA approval · 2023-11-08
  FDA Approved: FRUZAQLA — Original Application (Takeda Pharmaceuticals America, Inc.)

  FDA approved FRUZAQLA (fruquintinib) from Takeda Pharmaceuticals America, Inc. as an original NDA approval for metastatic colorectal cancer …

• CLINICAL_TRIALS trial_result · 2023-11-07
  Clinical Trial Update: A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Colorectal Cancer (Morpheus-CRC) [Phase 1, Phase 2]

  A Morpheus-CRC study evaluating immunotherapy-based treatment combinations in metastatic colorectal cancer has been terminated with results …

• CLINICAL_TRIALS trial_result · 2023-11-07
  Clinical Trial Update: Postoperative Chemotherapy With/Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With High Risk of Locally Recurrence [Phase 2]

  Phase 2 trial evaluating postoperative chemotherapy with or without radiotherapy and immunotherapy for colorectal liver metastases at high r…

• CLINICAL_TRIALS trial_result · 2023-11-07
  Clinical Trial Update: Crisaborole Ointment for Skin Toxicity Induced by Cetuximab [Phase 2]

  Phase 2 trial evaluating Crisaborole ointment to manage skin toxicity associated with cetuximab in metastatic colorectal cancer; current sta…

• CLINICAL_TRIALS trial_result · 2023-11-07
  Clinical Trial Update: FOLFIRI Alone Versus FOLFIRI Plus Bevacizumab Versus FOLFIRI Plus E7820 as Second-Line Therapy in Patients With Locally Advanced or Metastatic Colorectal Cancer [Phase 1, Phase 2]

  Clinical trial comparing FOLFIRI alone, FOLFIRI plus bevacizumab, and FOLFIRI plus E7820 as second-line therapy in locally advanced or metas…

• CLINICAL_TRIALS trial_result · 2023-11-07
  Clinical Trial Update: Liver Transplantation and Metastatic Colo-rectal Cancer. [Phase 2]

  Phase 2 clinical trial update related to liver transplantation for metastatic colorectal cancer.

• CLINICAL_TRIALS trial_result · 2023-11-07
  Clinical Trial Update: Clinical Study of Fruquintinib Combined With Raltitrexed in the Treatment of Metastatic Colorectal Cancer [Phase 4]

  A Phase 4 clinical trial evaluating the combination of Fruquintinib and Raltitrexed for metastatic colorectal cancer is currently recruiting…

• CLINICAL_TRIALS trial_result · 2023-11-03
  Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab Versus Standard of Care in Previously Treated Metastatic Colorectal Cancer With RAS Mutations [Phase 2]

  Phase 2 trial evaluating selinexor with or without pembrolizumab versus standard of care in previously treated metastatic colorectal cancer …

• CLINICAL_TRIALS trial_result · 2023-11-02
  Clinical Trial Update: Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer [Phase 4]

  A Phase 4 clinical trial evaluating the anticancer effect of pentoxiphylline in patients with metastatic colorectal cancer is described, sta…

• CLINICAL_TRIALS trial_result · 2023-11-01
  Clinical Trial Update: Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC [Phase 3]

  Phase 3 trial evaluating panitumumab and RAS mutation status as a diagnostically useful biomarker in metastatic colorectal cancer has comple…