Cocaine Use Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2018-06-26Clinical Trial Update: Methylphenidate-Duloxetine Combinations for Cocaine Dependence [Phase 1]
Phase 1 trial evaluating methylphenidate and duloxetine combinations for cocaine use disorder has been completed.
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CLINICAL_TRIALS trial_result · 2018-06-26Clinical Trial Update: A Novel Anti-Obesity Drug Combination as a Pharmacotherapy for Cocaine Dependence [EARLY_Phase 1]
This early-phase study reports the completion of a Phase 1 trial evaluating a novel anti-obesity drug combination as a pharmacotherapy for c…
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CLINICAL_TRIALS trial_result · 2018-06-26Clinical Trial Update: A Feasibility Trial for Inhibitory-Control Training to Reduce Cocaine Use [NA]
A completed feasibility trial from the University of Kentucky evaluated inhibitory-control training as a behavioral intervention to reduce c…
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CLINICAL_TRIALS trial_result · 2018-06-11Clinical Trial Update: Single Dose Crossover Comparative Bioavailability and Food Effect Study of Two EMB-001 Formulations [Phase 1]
A Phase 1 single-dose crossover study comparing two EMB-001 formulations to assess bioavailability and the effect of food in Cocaine Use Dis…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE) [Phase 1]
Phase 1 clinical trial evaluating behavioral and physiological effects of cocaine in cocaine-dependent participants treated with levodopa/ca…
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CLINICAL_TRIALS trial_result · 2018-05-16Clinical Trial Update: Dose Response Trial of Pergolide for Cocaine Dependence - 1 [Phase 3]
Phase 3 dose-response trial evaluating pergolide for cocaine use disorder has completed.
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CLINICAL_TRIALS trial_result · 2018-05-08Clinical Trial Update: Modafinil Treatment for Cocaine-Dependent Individuals [Phase 2]
Phase 2 trial of modafinil for cocaine use disorder has completed; results were posted in May 2018.
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CLINICAL_TRIALS trial_result · 2018-04-26Clinical Trial Update: PPARγ Agonist Treatment for Cocaine Dependence [Phase 1, Phase 2]
This clinical trial update reports Phase 1 and Phase 2 results for a PPAR gamma agonist being studied for cocaine use disorder, with partici…
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Effect of Clonidine on Responses to Imagery Scripts [Phase 1]
A Phase 1 trial evaluating clonidine’s impact on responses to imagery scripts in cocaine use disorder and opioid use disorder has completed.
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Effects of N-acetylcysteine on Brain Chemistry and Behavior in Cocaine Abusers (NAC)
A completed clinical trial evaluated the effects of N-acetylcysteine on brain chemistry and behavior in individuals with cocaine use disorde…
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CLINICAL_TRIALS research · 2018-04-05Clinical Trial Update: Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
A development and feasibility study evaluating real-time assessment methods for craving, use, and abstinence in outpatient individuals with …
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CLINICAL_TRIALS trial_result · 2018-02-28Clinical Trial Update: Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence [Phase 3]
Phase 3 clinical trial update evaluating naltrexone in two psychosocial treatment models for cocaine use disorder and alcohol use disorder, …
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CLINICAL_TRIALS trial_result · 2017-10-25Clinical Trial Update: Mirtazapine for Treating Cocaine Dependent Individuals Who Also Suffer From Depression [Phase 2]
A Phase 2 clinical trial evaluated mirtazapine for cocaine use disorder in individuals with co-occurring depression; the study was completed…
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CLINICAL_TRIALS trial_result · 2017-09-11Clinical Trial Update: Effects of Aripiprazole on Cocaine Craving and Self-Administration [Phase 2]
Phase 2 trial assessing aripiprazole for reducing cocaine craving and self-administration; results posted after completion.
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CLINICAL_TRIALS withdrawal · 2017-08-02Clinical Trial Update: Brain Imaging: Cocaine Effects & Medication Development - 5 [Phase 4]
Phase 4 brain imaging trial studying cocaine effects and potential medications has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-08-01Clinical Trial Update: A Study of Metyrapone and Oxazepam Combination Product (EMB-001) and Cocaine [Phase 1]
The Phase 1 trial evaluating EMB-001, a metyrapone and oxazepam combination, for Cocaine Use Disorder has completed.
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CLINICAL_TRIALS trial_result · 2017-07-11Clinical Trial Update: Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals [Phase 2]
Phase 2 clinical trial evaluated venlafaxine for reducing cocaine dependence in individuals with depression. The study status is completed.
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CLINICAL_TRIALS trial_result · 2017-07-05Clinical Trial Update: New Approaches to Cocaine Abuse Medications (A) - 6 [Phase 2]
This update notes the completion of a Phase 2 clinical trial evaluating new medications for cocaine-related disorders, including substance-r…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Risk Perception in Drug-Dependent Adults With and Without Schizophrenia
A completed clinical trial update from NIDA examining risk perception in adults with cocaine or cannabis use disorders, comparing those with…
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CLINICAL_TRIALS withdrawal · 2017-07-02Clinical Trial Update: Psychology of Reward and Punishment: Functional and Molecular Brain Imaging and Monoaminergic Correlates
This clinical trial examining functional and molecular brain imaging and monoaminergic correlates in cocaine use disorder has been withdrawn…
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CLINICAL_TRIALS trial_result · 2017-06-26Clinical Trial Update: Early Phase II Trials for Cocaine Medication Development - 1 [Phase 2]
The document reports the completion of an early-phase II clinical trial investigating a cocaine-related disorder medication conducted by the…
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CLINICAL_TRIALS trial_result · 2017-06-02Clinical Trial Update: Dexamphetamine Sustained Release Pharmacokinetics and Clinical Validation of Dried Blood Spots [EARLY_Phase 1]
This early-phase trial investigates the pharmacokinetics of sustained-release dexamphetamine and validates dried blood spot sampling in indi…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: Impulsivity, Brain Function, and Substance Abuse Treatment in Cocaine Dependent Individuals
This completed clinical study explored the relationships among impulsivity, brain function, and treatment outcomes in individuals dependent …
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CLINICAL_TRIALS trial_result · 2017-04-07Clinical Trial Update: Medications for Stopping Cocaine Dependence and Preventing Relapse [Phase 2]
A Phase 2 clinical trial evaluating medications to stop cocaine dependence and prevent relapse has completed, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-04-07Clinical Trial Update: Carbamazepine Treatment of Cocaine Dependence - 1 [Phase 2]
This update reports the completion of a Phase 2 trial evaluating carbamazepine for cocaine use disorder.