Cocaine Use Disorder
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CLINICAL_TRIALS trial_result · 2025-10-21Clinical Trial Update: Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2) [Phase 2]
Phase 2 CURB-2 trial evaluating extended-release naltrexone and monthly extended-release buprenorphine for Cocaine Use Disorder has complete…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project [NA]
This clinical trial update reports results from the Ways of Rewarding Abstinence project, which investigates neurocognitive factors that inf…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder [Phase 2]
A Phase 2 clinical trial is evaluating transdermal rotigotine as an adjunct to behavioral therapy for cocaine use disorder and is currently …
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: Neurocircuit Strategy to Decrease Cocaine Cue Reactivity [Phase 2]
Phase 2 trial evaluating a neurocircuit strategy to reduce cocaine cue reactivity has completed, with results posted.
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Targeting Drug Memories With Methylphenidate [EARLY_Phase 1]
This early Phase 1 study investigates using methylphenidate to target drug memories in cocaine use disorder; the trial is currently active b…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
A Yale-sponsored PET imaging study investigates aberrant synaptic plasticity in cocaine use disorder using the 11C-UCB-J radioligand. The tr…
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CLINICAL_TRIALS trial_result · 2025-08-24Clinical Trial Update: Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV [Phase 2]
A Phase 2 clinical trial is evaluating semaglutide for cocaine use disorder in adults, with and without HIV, and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: Cocaine and Zolmitriptan [EARLY_Phase 1]
Early Phase 1 study evaluating zolmitriptan for cocaine use disorder has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: Psilocybin-facilitated Treatment for Cocaine Use [Phase 2]
Phase 2 trial evaluating psilocybin-facilitated treatment for cocaine use disorder has completed at the University of Alabama at Birmingham.
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CLINICAL_TRIALS trial_result · 2025-07-29Clinical Trial Update: Multiple Ascending Dose Study of TMP-301 in Healthy Subjects [Phase 1]
Tempero Bio completed a Phase 1 multiple ascending dose study of TMP-301 in healthy volunteers, with results posted. The investigation inclu…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Cocaine Cue-reactivity Incubation Study [NA]
A clinical trial sponsored by Icahn School of Medicine at Mount Sinai is currently recruiting participants for Cocaine Use Disorder.
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: Intranasal Cocaine and Temperature Regulation During Exercise [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating intranasal cocaine for temperature regulation during exercise; results have been posted following comple…
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CLINICAL_TRIALS trial_result · 2025-06-24Clinical Trial Update: Comparing Efficacy & Safety Of TNX-1300 To Placebo With UC For Treatment Of Acute Cocaine Intoxication In ED Subjects (CATALYST) [Phase 2]
A Phase 2 trial comparing TNX-1300 to placebo for acute cocaine intoxication in ED patients was terminated. The snippet does not provide eff…
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CLINICAL_TRIALS trial_result · 2025-06-05Clinical Trial Update: Imaging CRF X NOP Interactions in CUD [EARLY_Phase 1]
Early-phase clinical trial exploring imaging-based CRF and NOP receptor interactions in cocaine use disorder. Current status: recruiting.
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: [C-11]NPA PET-amphetamine in Cocaine Use Disorders [EARLY_Phase 1]
An early-phase clinical trial studying the PET tracer [C-11]NPA in cocaine use disorder. The study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-18Clinical Trial Update: A Study to Investigate the Interaction Between TMP-301 and Cocaine. [Phase 1]
A Phase 1 study evaluating the interaction between TMP-301 and cocaine in individuals with Cocaine Use Disorder has completed.
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CLINICAL_TRIALS research · 2025-05-08Clinical Trial Update: Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder [NA]
This clinical trial aims to identify electrophysiological targets for transcranial magnetic stimulation in Cocaine Use Disorder and is curre…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: Neurobehavioral Mechanisms of Cocaine Choice [EARLY_Phase 1]
Completed early-phase study investigating neurobehavioral mechanisms of cocaine choice in individuals with cocaine use disorder; results hav…
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CLINICAL_TRIALS trial_result · 2025-02-25Clinical Trial Update: Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use [NA]
A National Institute on Drug Abuse-sponsored trial testing theta-burst stimulation to reduce cocaine use has been terminated. Results were p…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: rTMS for Stimulant Use Disorders [NA]
A completed clinical trial evaluating repetitive transcranial magnetic stimulation (rTMS) for cocaine use disorder and methamphetamine use d…
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CLINICAL_TRIALS research · 2024-12-20Clinical Trial Update: Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction [Phase 2]
A Phase 2 trial evaluating ketamine with neurofeedback training for effects on neuroplasticity in cocaine use disorder, currently recruiting…
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CLINICAL_TRIALS research · 2024-11-27Clinical Trial Update: Leveraging Psychological Autopsies to Accelerate Research Into Stimulant Overdose Mortality
Clinical trial update describing the use of psychological autopsies to accelerate research into stimulant overdose mortality. The update not…
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CLINICAL_TRIALS research · 2024-11-22Clinical Trial Update: Role of Pavlovian Mechanisms for Control Over Substance Use
An ongoing study from Technische Universität Dresden is exploring Pavlovian mechanisms for controlling substance use, with recruitment under…
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CLINICAL_TRIALS trial_result · 2024-11-18Clinical Trial Update: TDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study [Phase 2]
Phase 2 study evaluating transcranial direct current stimulation (TDCS) to reduce cravings in cocaine use disorder has completed.
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CLINICAL_TRIALS trial_result · 2024-11-18Clinical Trial Update: TDCS for Cocaine Addiction Craving [NA]
A clinical trial evaluating transcranial direct current stimulation (TDCS) for reducing cocaine craving in cocaine use disorder/dependence h…