Cocaine Dependence
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder [NA]
A clinical trial sponsored by the New York State Psychiatric Institute is evaluating repetitive transcranial magnetic stimulation with cogni…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder [NA]
A clinical trial update indicates that a study evaluating transcranial direct current stimulation as a treatment for cocaine use disorder is…
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: Safety Study of a Disrupted Adenovirus (Ad) Serotype Cocaine Vaccine for Cocaine-dependent Individuals [Phase 1]
Phase 1 safety study evaluating a disrupted adenovirus-based cocaine vaccine for individuals with cocaine dependence.
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CLINICAL_TRIALS withdrawal · 2025-10-20Clinical Trial Update: Rebalancing the Serotonergic System in Cocaine Dependence [Phase 1]
Phase 1 trial investigating rebalancing the serotonergic system for cocaine dependence was withdrawn.
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT [Phase 1, Phase 2]
Early-phase study using the PET tracer FLUORTRIOPRIDE ([18F]FTP) to evaluate D3 receptor occupancy in cocaine-dependent individuals and heal…
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CLINICAL_TRIALS trial_result · 2025-02-25Clinical Trial Update: Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use [NA]
A National Institute on Drug Abuse-sponsored trial testing theta-burst stimulation to reduce cocaine use has been terminated. Results were p…
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CLINICAL_TRIALS research · 2024-12-20Clinical Trial Update: Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction [Phase 2]
A Phase 2 trial evaluating ketamine with neurofeedback training for effects on neuroplasticity in cocaine use disorder, currently recruiting…
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CLINICAL_TRIALS trial_result · 2024-11-18Clinical Trial Update: TDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study [Phase 2]
Phase 2 study evaluating transcranial direct current stimulation (TDCS) to reduce cravings in cocaine use disorder has completed.
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CLINICAL_TRIALS trial_result · 2024-11-18Clinical Trial Update: TDCS for Cocaine Addiction Craving [NA]
A clinical trial evaluating transcranial direct current stimulation (TDCS) for reducing cocaine craving in cocaine use disorder/dependence h…
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CLINICAL_TRIALS research · 2024-05-02Clinical Trial Update: Clavulanic Acid for the Treatment of Cocaine Use Disorder [Phase 2]
This document updates the status of a Phase 2 trial evaluating clavulanic acid for cocaine dependence, noting the study is currently active …
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CLINICAL_TRIALS trial_result · 2023-12-13Clinical Trial Update: Randomized, Double-blind, Placebo-controlled Cannabis Extract x Placebo for Cocaine Addicts [Phase 4]
A Phase 4 randomized, double-blind trial evaluating cannabis extract vs placebo for cocaine dependence; current status is unknown.
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CLINICAL_TRIALS trial_result · 2023-11-03Clinical Trial Update: Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study [Phase 1]
Phase 1 trial evaluating safety of clavulanic acid (CLAV) interaction with cocaine in individuals with cocaine dependence; results completed…
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CLINICAL_TRIALS trial_result · 2023-10-06Clinical Trial Update: Investigation of Cocaine Addiction Using mGluR5 PET and fMRI [Phase 1]
Phase 1 clinical trial investigating cocaine dependence using mGluR5 PET and fMRI; trial completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-06-22Clinical Trial Update: Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid [Phase 1]
Phase 1 clinical trial update on a pharmacochemical study of clavulanic acid using magnetic resonance spectroscopy for cocaine dependence; r…
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CLINICAL_TRIALS trial_result · 2022-01-25Clinical Trial Update: A Sequenced Behavioral and Medication Intervention for Cocaine Dependence [Phase 1, Phase 2]
A sequenced behavioral and medication intervention for cocaine dependence completed Phase 1 and Phase 2 trials with results posted.
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CLINICAL_TRIALS trial_result · 2021-11-22Clinical Trial Update: 5HT2CR Balance in Brain Connectivity in Cocaine Dependence [Phase 1, Phase 2]
Phase 1/2 study assessing 5-HT2C receptor balance in brain connectivity for cocaine dependence; completed with posted results.
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CLINICAL_TRIALS trial_result · 2021-11-11Clinical Trial Update: New Medication Treatment for Stimulant Dependence [Phase 2]
Phase 2 clinical trial update for a new medication targeting stimulant dependence (cocaine dependence) with completed status and posted resu…
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CLINICAL_TRIALS trial_result · 2021-10-29Clinical Trial Update: Cocaine Use Reduction With Buprenorphine [Phase 2, Phase 3]
Phase 2/3 clinical trial investigating buprenorphine for reducing cocaine use in cocaine dependence; results posted after completion.
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CLINICAL_TRIALS trial_result · 2021-09-20Clinical Trial Update: Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating Bupropion-enhanced contingency management for cocaine dependence has completed and posted results.
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CLINICAL_TRIALS trial_result · 2021-04-20Clinical Trial Update: A Safety, Tolerability and Pharmacokinetic Study of CPP-115 [Phase 1]
Phase 1 study evaluating safety, tolerability, and pharmacokinetics of CPP-115 in cocaine dependency has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-11-19Clinical Trial Update: Disulfiram for Cocaine Abuse in Buprenorphine Treatment [Phase 2]
Phase 2 clinical trial investigating disulfiram for cocaine dependence in individuals receiving buprenorphine for opioid dependence has comp…
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CLINICAL_TRIALS trial_result · 2020-10-23Clinical Trial Update: Cannabidiol and Cocaine Craving/Dependence [Phase 2]
Phase 2 clinical trial exploring cannabidiol for cocaine craving and dependence has completed.
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CLINICAL_TRIALS trial_result · 2020-10-22Clinical Trial Update: Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET [NA]
Clinical trial investigating dopamine mechanisms in cocaine dependence using AMPT and methylphenidate with PET imaging; status terminated wi…
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CLINICAL_TRIALS trial_result · 2020-08-31Clinical Trial Update: Citalopram for Cocaine Dependence [Phase 2]
Phase 2 clinical trial update evaluating citalopram for cocaine dependence has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-08-18Clinical Trial Update: Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving [Phase 2]
Phase 2 trial update evaluating varenicline's impact on craving for cocaine and alcohol in people with dependence, with results posted.