Clostridioides Difficile Infection
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-03-08Clinical Trial Update: Pathogenic Mechanisms in C Diff Infection and Colitis
This clinical trial update summarizes a completed study on pathogenic mechanisms in Clostridioides difficile infection and colitis.
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CLINICAL_TRIALS trial_result · 2017-01-30Clinical Trial Update: A Study To Investigate A Clostridium Difficile Vaccine In Healthy Adults Aged 50 to 85 Years, Who Will Each Receive 3 Doses Of Vaccine. [Phase 2]
Pfizer conducted a Phase 2 study to evaluate a Clostridioides difficile vaccine in healthy adults aged 50 to 85 who received three doses; th…
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CLINICAL_TRIALS trial_result · 2017-01-25Clinical Trial Update: Small Bowel Transit Time in Clostridium Difficile Colitis
A terminated clinical trial evaluated small bowel transit time in patients with Clostridioides difficile infection.
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CLINICAL_TRIALS research · 2017-01-19Clinical Trial Update: Evaluation of the Cost of a Nosocomial Infection With Clostridium Difficile
This update reports on a completed clinical trial evaluating the cost of hospital-acquired Clostridioides difficile infection.
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CLINICAL_TRIALS withdrawal · 2016-12-14Clinical Trial Update: Extended Treatment With Vancomycin for Clostridium Difficile Colitis [NA]
The clinical trial NCT00861887 evaluating extended vancomycin treatment for Clostridioides difficile infection has been withdrawn.
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CLINICAL_TRIALS trial_result · 2016-11-23Clinical Trial Update: Probiotics for Prevention of Antibiotic Associated Diarrhea and Clostridium Difficile Associated Disease [NA]
A clinical trial evaluating probiotics to prevent antibiotic-associated diarrhea and Clostridioides difficile infection was terminated.
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CLINICAL_TRIALS trial_result · 2016-10-31Clinical Trial Update: Probiotics in the Reduction of Antibiotic Associated Diarrhea [Phase 1]
Phase 1 trial evaluating probiotics to reduce antibiotic-associated diarrhea in connection with Clostridioides difficile infection; the stud…
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FDA approval · 2016-10-21FDA Approved: ZINPLAVA — Original Application (Merck Sharp & Dohme LLC)
FDA approved ZINPLAVA (bezlotoxumab) from Merck Sharp & Dohme LLC under an original Biologics License Application. It is indicated to reduce…
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CLINICAL_TRIALS trial_result · 2016-10-20Clinical Trial Update: A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD) [Phase 2]
A Phase 2 trial comparing SMT19969 with vancomycin for Clostridioides difficile infection has completed.
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CLINICAL_TRIALS trial_result · 2016-10-17Clinical Trial Update: Prospective Observational Study of Clostridium Difficile Infection in Asian Pacific Countries
A completed prospective observational study of Clostridioides difficile infection across Asian Pacific countries, with results posted.
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CLINICAL_TRIALS trial_result · 2016-10-13Clinical Trial Update: Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury [Phase 4]
Phase 4 trial comparing oral fidaxomicin to oral vancomycin for Clostridioides difficile infection in patients with spinal cord injury was t…
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CLINICAL_TRIALS trial_result · 2016-09-01Clinical Trial Update: Stool Transplant in Pediatric Patients With Recurring C. Difficile Infection [Phase 2]
A Phase 2 clinical trial evaluating stool transplant for pediatric patients with recurring Clostridioides difficile infection has completed.
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CLINICAL_TRIALS trial_result · 2016-07-22Clinical Trial Update: A Study of Ascending Multiple Doses of Oral Surotomycin in Healthy Participants (MK-4261-009) [Phase 1]
Phase 1 study of ascending multiple oral doses of surotomycin in healthy participants has completed, evaluating safety and tolerability.
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CLINICAL_TRIALS trial_result · 2016-07-22Clinical Trial Update: A Study of Ascending Single Doses of Surotomycin in Healthy Participants (MK-4261-008) [Phase 1]
Phase 1 study of ascending single doses of surotomycin in healthy participants, with Clostridioides difficile infection (CDAD) listed as the…
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CLINICAL_TRIALS trial_result · 2016-07-19Clinical Trial Update: Fecal Microbiota Transplant for Relapsing Clostridium Difficile Infection in Adults and Children Using a Frozen Encapsulated Inoculum [Phase 1]
A Phase 1 trial at Massachusetts General Hospital evaluating a frozen encapsulated fecal microbiota transplant for relapsing Clostridioides …
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CLINICAL_TRIALS trial_result · 2016-07-18Clinical Trial Update: Probiotic Saccharomyces Boulardii for the Prevention of Antibiotic-associated Diarrhoea [Phase 3]
Phase 3 trial evaluating Saccharomyces boulardii for prevention of antibiotic-associated diarrhea was terminated; results were posted in 201…
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CLINICAL_TRIALS trial_result · 2016-07-15Clinical Trial Update: IVIG Versus Placebo for the Treatment of Patients With Severe C-Diff [Phase 4]
Phase 4 trial evaluating intravenous immunoglobulin (IVIG) versus placebo for severe Clostridioides difficile infection was terminated; resu…
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CLINICAL_TRIALS trial_result · 2016-07-11Clinical Trial Update: Chlorhexidine Bathing Effect on Clostridium Difficile Rates [Phase 2]
Completed Phase 2 trial evaluating the effect of chlorhexidine bathing on rates of Clostridioides difficile infection.
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CLINICAL_TRIALS trial_result · 2016-06-13Clinical Trial Update: Phase I Trial to Determine the Safety and Pharmacokinetics of CRS3123. [Phase 1]
Phase I trial update reporting the safety and pharmacokinetics of CRS3123 in participants with Clostridioides difficile infection. The study…
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CLINICAL_TRIALS trial_result · 2016-06-10Clinical Trial Update: Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients [Phase 4]
This Phase 4 trial evaluated metronidazole as prophylaxis to prevent Clostridioides difficile infection in high-risk adults; the study was t…
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CLINICAL_TRIALS research · 2016-05-25Clinical Trial Update: Freeze-dried, Capsulized FMT for RCDI [Phase 1]
Phase 1 trial evaluating freeze-dried, capsulized fecal microbiota transplant for recurrent Clostridioides difficile infection, sponsored by…
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CLINICAL_TRIALS trial_result · 2016-05-03Clinical Trial Update: Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy [Phase 4]
Phase 4 clinical trial evaluating the efficacy of loperamide for Clostridioides difficile infection and antibiotic-associated diarrhea; the …
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CLINICAL_TRIALS trial_result · 2016-04-21Clinical Trial Update: The Risk for Clostridium Difficile Colitis During Hospitalization in Asymptomatic Carriers
A completed clinical trial evaluated the risk of Clostridioides difficile infection–associated colitis during hospitalization in asymptomati…
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CLINICAL_TRIALS trial_result · 2016-02-23Clinical Trial Update: Molecular Epidemiology of Clostridium Difficile Infections in Children
A completed pediatric study examining the molecular epidemiology of Clostridioides difficile infections, with results posted in 2016.
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CLINICAL_TRIALS trial_result · 2016-01-27Clinical Trial Update: Probiotic Intervention With Elderly Subjects [Phase 2]
Phase 2 clinical trial update on a probiotic intervention in elderly subjects with Clostridioides difficile infection; the study has complet…