Cisplatin-induced Ototoxicity
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Protective Effect of Acetylcysteine Against Cisplatinum-Induced Ototoxicity: A Randomized Controlled Trial [Phase 2]
A Phase 2 randomized controlled trial is evaluating whether acetylcysteine can protect against cisplatin-induced ototoxicity in patients und…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Transtympanic STS Against Cisplatin-induced SNHL: the SOUND Trial [Phase 3]
Phase 3 SOUND trial is actively recruiting to evaluate transtympanic sodium thiosulfate for preventing cisplatin-induced sensorineural heari…
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FDA approval · 2022-09-20FDA Approved: PEDMARK — Original Application (Fennec Pharmaceuticals Inc.)
FDA approved PEDMARK (sodium thiosulfate) from Fennec Pharmaceuticals in an original NDA to prevent cisplatin-induced hearing loss in pediat…
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CLINICAL_TRIALS trial_result · 2021-07-28Clinical Trial Update: Evaluation of the Effect of Rosuvastatin on Cisplatin-induced Nephrotoxicity and Ototoxicity [Phase 2]
Phase 2 clinical trial evaluating whether rosuvastatin mitigates cisplatin-induced nephrotoxicity and ototoxicity.
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CLINICAL_TRIALS trial_result · 2019-10-09Clinical Trial Update: Randomized Trial Comparison of Ototoxicity Monitoring Programs [NA]
Completed randomized trial comparing ototoxicity monitoring programs in patients receiving cisplatin, with results posted in 2019.
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CLINICAL_TRIALS trial_result · 2014-07-17Clinical Trial Update: Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment [Phase 4]
A Phase 4 clinical trial evaluated whether intratympanic dexamethasone can prevent cisplatin-induced ototoxicity (hearing loss) after cispla…
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CLINICAL_TRIALS research · 2011-01-28Clinical Trial Update: Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin. [NA]
This clinical trial update concerns the use of intratympanic steroid therapy to prevent inner ear toxicity associated with systemic cisplati…