Cirrhosis
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: A Study to Evaluate the Pharmacokinetics and Safety of K-808 (Pemafibrate) in Subjects With Primary Biliary Cholangitis With Compensated Cirrhosis and Without Cirrhosis. [Phase 1]
Phase 1 study evaluating the pharmacokinetics and safety of pemafibrate (K-808) in subjects with primary biliary cholangitis with compensate…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Effect of Non-Selective Beta-Blockers on Outcomes in Cirrhosis Patients After Hospitalization: A Retrospective Cohort Using Target Trial Design
This retrospective cohort study uses a target trial design to evaluate whether non-selective beta-blockers influence outcomes in cirrhosis p…
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CLINICAL_TRIALS trial_result · 2025-05-16Clinical Trial Update: Composition for Treating Cirrhosis and Liver Cancer (SB-1121) [Phase 4]
Phase 4 clinical trial update indicating completion of SB-1121 for cirrhosis of the liver.
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CLINICAL_TRIALS trial_result · 2025-05-16Clinical Trial Update: Mild Hypothermia and Acute Kidney Injury in Liver Transplantation [NA]
A terminated UCSF-led clinical trial evaluated mild hypothermia for reducing acute kidney injury after liver transplantation, with results p…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients [Phase 2, Phase 3]
NEPH-ROSIS, a Phase 2/3 pilot trial for treating acute kidney injury in hospitalized cirrhosis patients, has been terminated.
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Exploring Clinical Characteristics of Liver Disease Patients Based on Digestive Metabolic Exhaled Air
This recruiting clinical trial investigates the clinical characteristics of liver disease patients, focusing on cirrhosis, using digestive m…
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CLINICAL_TRIALS research · 2025-05-09Clinical Trial Update: Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial is exploring fecal microbiota transplantation for alcohol-related liver disease and cirrhosis and is currently re…
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CLINICAL_TRIALS trial_result · 2025-05-09Clinical Trial Update: Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients [Phase 4]
Phase 4 trial in cirrhosis comparing the diuretic effect of furosemide alone versus furosemide with albumin; the study was terminated and re…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant
This clinical trial update describes a study investigating changes in glucose tolerance in patients with cirrhosis around liver transplantat…
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis [Phase 3]
Phase 3 trial of Namodenoson for advanced hepatocellular carcinoma in patients with Child-Pugh B7 cirrhosis is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Microbiota Study in Liver Transplanted Patients
A microbiota-focused clinical trial in patients with cirrhosis and hepatocellular carcinoma undergoing liver transplantation has completed.
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: Effects of Metformin on Hepatic Venous Pressure Gradient in Patients With Cirrhosis and Portal Hypertension [Phase 2]
Phase 2 clinical trial evaluating the effects of metformin on hepatic venous pressure gradient in patients with cirrhosis and portal hyperte…
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CLINICAL_TRIALS trial_result · 2025-04-10Clinical Trial Update: Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites [Phase 3]
A Phase 3 trial comparing two strategies for primary prophylaxis of spontaneous bacterial peritonitis in patients with cirrhosis and ascites…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: A Study of Efruxifermin in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) (Symmetry) [Phase 2]
A Phase 2 clinical trial update for efruxifermin in adults with nonalcoholic steatohepatitis and compensated cirrhosis shows the study is ac…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Clinical Study to Evaluate the Efficacy and Safety of Dapagliflozin in Patients With Refractory Cirrhotic Ascites [Phase 2]
Phase 2 clinical study evaluating the efficacy and safety of dapagliflozin in patients with refractory cirrhotic ascites. The trial is not y…
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Extracellular RNA Markers of Liver Disease and Cancer
This ClinicalTrials.gov update reports on a Mayo Clinic-sponsored study investigating extracellular RNA markers in liver disease and cancer,…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: A Study to Evaluate Role of Inhaled Amikacin to Prevent Ventilator Associated Pneumonia in Patients With Cirrhosis [Phase 4]
A Phase 4 trial is evaluating inhaled amikacin to prevent ventilator-associated pneumonia in patients with cirrhosis (including hepatic ence…
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CLINICAL_TRIALS research · 2025-04-03Clinical Trial Update: Fecal Calprotectin for Prediction of Esophageal Varices in Cirrhotic Patients
This clinical trial update indicates a study evaluating fecal calprotectin as a predictor of esophageal varices in cirrhotic patients, with …
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CLINICAL_TRIALS research · 2025-04-03Clinical Trial Update: Utility of ROTEM® for Risk Stratification of Post-Invasive Procedure Hemorrhage in Patients With Cirrhosis (CIR-ROTEM)
A clinical trial update on CIR-ROTEM evaluating ROTEM-based risk stratification for post-invasive procedure hemorrhage in patients with cirr…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: Metobolomics in the Characterisation of HE
The document reports completion of a metabolomics study aimed at characterizing hepatic encephalopathy in patients with cirrhosis.
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients [NA]
Clinical trial evaluating the medical-economic aspects of using the Alfapump device to treat refractory ascites in cirrhotic patients.
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: Apixaban, Warfarin and Aspirin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy（ESAWAAPT） [Phase 4]
A Phase 4 trial assessed whether apixaban, warfarin, and aspirin can prevent portal vein thrombosis after laparoscopic splenectomy in patien…
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CLINICAL_TRIALS research · 2025-03-19Clinical Trial Update: Predictors of Spontaneous Bacterial Peritonitis Among Patients with Cirrhosis
Clinical trial evaluating predictors of spontaneous bacterial peritonitis in patients with Cirrhosis. The study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients [Phase 4]
Phase 4 clinical trial evaluating tranexamic acid and vitamin K injection to control upper gastrointestinal bleeding in cirrhotic patients i…
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CLINICAL_TRIALS trial_result · 2025-03-17Clinical Trial Update: An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI) [Phase 1]
An open-label Phase 1 study evaluating oral dosing of seladelpar in adults with primary biliary cholangitis and hepatic impairment (compensa…