Rhinosinusitis Without Nasal Polyps
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma
A clinical trial update assessing the effectiveness of mepolizumab for patients with chronic rhinosinusitis with nasal polyps and comorbid s…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Evaluation of Nasal Biomarkers for Objective Assessment of Disease Severity in Respiratory Disorders
A completed clinical trial evaluating nasal biomarkers for objective assessment of disease severity in chronic respiratory diseases, includi…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps [Phase 3]
A Phase 3 clinical trial update evaluating 186 mcg of OPN-375 nasal spray twice daily in adolescents with chronic rhinosinusitis without nas…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Pistacia Lentiscus Oil Nasal Drops for Preventing Recurrence of Chronic Rhinosinusitis [NA]
A completed clinical trial evaluating Pistacia lentiscus oil nasal drops to prevent recurrence of chronic rhinosinusitis.
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis [NA]
ClinicalTrials.gov entry for a study of paclitaxel-coated balloon treatment in chronic rhinosinusitis with and without nasal polyps; the tri…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti--IL-33 mAb) in Participants With Chronic Rhinosinusitis Without Nasal Polyps [Phase 2]
A Phase 2 proof-of-concept trial is evaluating itepekimab, an anti-IL-33 monoclonal antibody, for efficacy, safety, and tolerability in adul…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of Brensocatib in chronic rhinosinusitis without nasal polyps has completed.
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CLINICAL_TRIALS trial_result · 2025-11-03Clinical Trial Update: Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) [Phase 2]
This clinical trial update reports the efficacy of dupilumab in patients with chronic rhinosinusitis without nasal polyps in a Phase 2 study…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS). [Phase 2, Phase 3]
Ongoing clinical trial update for a sinonasal microbiome transplant as a therapy for chronic rhinosinusitis, currently in Phase 2/3 and recr…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of HTMC0658 Tablets in the Treatment of Chronic Rhinosinusitis Without Nasal Polyps [Phase 2]
A Phase 2 trial is evaluating the efficacy and safety of HTMC0658 tablets for chronic rhinosinusitis without nasal polyps; the study is curr…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: CRS Questionnaire Validation Project
A clinical trial update announcing recruitment for a European project to validate a questionnaire for chronic rhinosinusitis with and withou…
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps. [Phase 2]
Phase 2 clinical study of TQH2722 Injection for chronic sinusitis with or without nasal polyps has completed.
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CLINICAL_TRIALS research · 2025-06-04Clinical Trial Update: The German National CRS Registry (GenreCRS): Clinical Evaluation of the New European Academy for Allergy and Clinical Immunology (EAACI) Criteria for CRSwNP Disease Control, Remission and Cure in a Real-World Evidence Study Approach
This clinical trial registry entry describes a real-world study evaluating EAACI criteria for disease control, remission, and cure in chroni…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With CRSwNP
An ongoing clinical trial is evaluating the effect of dupilumab on nasal epithelial barrier function in patients with chronic rhinosinusitis…
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CLINICAL_TRIALS research · 2025-03-21Clinical Trial Update: 3D Printing to Improve Nasal Irrigation Outcome [NA]
A clinical trial sponsored by Ohio State University is evaluating whether 3D-printed nasal irrigation devices improve outcomes in chronic rh…
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Dupilumab in CRSsNP [Phase 3]
Phase 3 trial of dupilumab in chronic rhinosinusitis without nasal polyps has completed with results posted.
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CLINICAL_TRIALS research · 2024-12-17Clinical Trial Update: Correlation of Preoperative Indices (serum Vit D, Calcium, Phosphorus, FAR, PLR, SII) on Intraoperative Bleeding in CRS
This clinical trial update examines whether preoperative indices (serum vitamin D, calcium, phosphorus, FAR, PLR, and SII) correlate with in…
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CLINICAL_TRIALS trial_result · 2024-04-17Clinical Trial Update: Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment [Phase 4]
Phase 4 trial evaluating immune profiles in chronic rhinosinusitis patients after mepolizumab treatment; currently recruiting.
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CLINICAL_TRIALS trial_result · 2023-09-18Clinical Trial Update: Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps [Phase 3]
Phase 3 trial results for intranasal OPN-375 in chronic rhinosinusitis with or without nasal polyps have been posted following study complet…
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CLINICAL_TRIALS trial_result · 2021-07-30Clinical Trial Update: GB001 in Adult Participants With Chronic Rhinosinusitis [Phase 2]
Phase 2 clinical trial update for GB001 in adults with chronic rhinosinusitis, including CRSsNP and CRSwNP; trial completed with results pos…
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CLINICAL_TRIALS withdrawal · 2019-08-28Clinical Trial Update: Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) [Phase 4]
Phase 4 trial on systemic corticosteroids for perioperative management of chronic rhinosinusitis without nasal polyps has been withdrawn.
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CLINICAL_TRIALS research · 2018-04-05Clinical Trial Update: DNA Microarray Analysis of Gene Expression in Chronic Rhinosinusitis
This clinical trial update reports findings from DNA microarray analysis of gene expression in chronic rhinosinusitis without nasal polyps. …
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CLINICAL_TRIALS trial_result · 2018-03-30Clinical Trial Update: Nanoparticles in Nasal Mucosa
A completed clinical trial from University Hospital Ostrava studying nanoparticles applied to nasal mucosa for chronic rhinosinusitis condit…
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CLINICAL_TRIALS trial_result · 2018-03-21Clinical Trial Update: Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis [Phase 3]
Phase 3 clinical trial update for Gel-Sinuplasty in chronic rhinosinusitis with and without nasal polyps; current status is unknown.
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CLINICAL_TRIALS trial_result · 2017-05-08Clinical Trial Update: Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) [Phase 4]
A Phase 4 trial evaluating corticosteroid therapy for chronic rhinosinusitis without nasal polyps was terminated, with results posted in 201…