Myelomonocytic Leukemia

• CLINICAL_TRIALS trial_result · 2020-06-30
  Clinical Trial Update: Efficacy and Safety of IV Rigosertib in MDS Patients With Excess Blasts Progressing After Azacitidine or Decitabine [Phase 3]

  Phase 3 trial updating the efficacy and safety of intravenous rigosertib in myelodysplastic syndrome patients with excess blasts who progres…

• CLINICAL_TRIALS trial_result · 2020-06-23
  Clinical Trial Update: A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML). [Phase 1, Phase 2]

  Phase Ib/IIb open-label study evaluating oral panobinostat with 5-azacitidine in adults with myelodysplastic syndromes, chronic myelomonocyt…

• CLINICAL_TRIALS trial_result · 2020-05-28
  Clinical Trial Update: Azacitidine, Lenalidomide and DLI as Salvage Therapy for MDS, CMML and sAML Relapsing After Allo-HSCT [Phase 2]

  Phase 2 clinical trial evaluating azacitidine, lenalidomide, and donor lymphocyte infusion as salvage therapy for relapsed diseases after al…

• CLINICAL_TRIALS trial_result · 2020-03-12
  Clinical Trial Update: A Sequential Two-Stage Dose Escalation Study to Evaluate the Safety and Efficacy of Ruxolitinib [Phase 1, Phase 2]

  Completed Phase 1/2 trial evaluating safety and efficacy of ruxolitinib in myelomonocytic leukemia.

• CLINICAL_TRIALS trial_result · 2020-01-21
  Clinical Trial Update: Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT [Phase 1]

  Phase 1 trial exploring a calcineurin inhibitor-free graft-versus-host disease prevention regimen after related haploidentical peripheral bl…

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• CLINICAL_TRIALS trial_result · 2020-01-07
  Clinical Trial Update: Erlotinib Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Phase 2]

  Phase 2 clinical trial evaluating erlotinib hydrochloride in relapsed or refractory acute myeloid leukemia has completed with posted results…

• CLINICAL_TRIALS trial_result · 2019-09-06
  Clinical Trial Update: WEE1 Inhibitor AZD1775 With or Without Cytarabine in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome [Phase 2]

  Phase 2 trial evaluating the WEE1 inhibitor AZD1775 with or without cytarabine in advanced acute myeloid leukemia or myelodysplastic syndrom…

• CLINICAL_TRIALS trial_result · 2019-06-13
  Clinical Trial Update: Study of Sotatercept for the Treatment of Anemia in low-or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) or Non-proliferative Chronic Myelomonocytic Leukemia (CMML) [Phase 2]

  Phase 2 study evaluating sotatercept for anemia in patients with low- or intermediate-1 risk myelodysplastic syndromes and non-proliferative…

• CLINICAL_TRIALS trial_result · 2019-05-06
  Clinical Trial Update: Dasatinib as Therapy for Myeloproliferative Disorders (MPDs) [Phase 2]

  Phase 2 trial evaluating dasatinib for myeloproliferative disorders; the study has completed and results were posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-04-23
  Clinical Trial Update: Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation [Phase 2]

  Phase 2 pilot trial evaluating leuprolide to enhance immune function after allogeneic bone marrow transplantation has completed and results …

• CLINICAL_TRIALS trial_result · 2019-03-05
  Clinical Trial Update: A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 and/or Ras Mutations [Phase 1, Phase 2]

  Clinical trial update for E6201 in advanced hematologic malignancies with FLT3 and/or Ras mutations (Phase 1/2) shows terminated status; res…

• CLINICAL_TRIALS trial_result · 2019-02-08
  Clinical Trial Update: Phase I Dose Escalation Trial of Volasertib in Combination With Azacitidine in Patients With MDS or CMML [Phase 1]

  Phase I dose-escalation study of volasertib in combination with azacitidine in patients with myelodysplastic syndromes or chronic myelomonoc…

• CLINICAL_TRIALS trial_result · 2019-01-25
  Clinical Trial Update: Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS [Phase 1]

  Phase 1 clinical trial evaluating Yttrium-90 anti-CD45 monoclonal antibody BC8 followed by donor stem cell transplant in patients with high-…

• CLINICAL_TRIALS trial_result · 2018-12-06
  Clinical Trial Update: A Phase II Trial of SGI-110 in Patients With IPSS High and Int 2 Myelodysplastic Syndrome, Acute Myeloid Leukemia With 20-30% Marrow Blasts or Chronic Myelomonocytic Leukemia Type 2 Not Responding to Azacitidine or Decitabine After at Least 6 Courses or Relapsing After a Response [Phase 2]

  Phase II trial evaluating SGI-110 in patients with various high-risk myelodysplastic syndromes and related conditions not responding to prio…

• CLINICAL_TRIALS trial_result · 2018-10-24
  Clinical Trial Update: Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders [Phase 2]

  Phase 2 clinical trial evaluating fludarabine phosphate and total body irradiation followed by donor peripheral stem cell transplant in myel…

• CLINICAL_TRIALS trial_result · 2018-07-30
  Clinical Trial Update: Volasertib in Combination With Azacitidine in Japanese Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia [Phase 1]

  Phase 1 trial evaluating volasertib in combination with azacitidine in Japanese patients with myelodysplastic syndromes or chronic myelomono…

• CLINICAL_TRIALS trial_result · 2018-06-25
  Clinical Trial Update: Multicenter Study to Assess the Efficacy of Decitabine in the Treatment of Chronic Myelomonocytic Leukemia [Phase 2]

  A multicenter Phase 2 trial evaluating decitabine for chronic myelomonocytic leukemia has completed.

• CLINICAL_TRIALS trial_result · 2018-06-04
  Clinical Trial Update: Tipifarnib in Treating Patients With Chronic Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or Undifferentiated Myeloproliferative Disorders [Phase 1, Phase 2]

  The document notes the completion of a Phase 1/2 clinical trial evaluating tipifarnib in patients with chronic myeloid leukemia, chronic mye…

• CLINICAL_TRIALS trial_result · 2018-05-21
  Clinical Trial Update: Treo/Flu/TBI With Donor Stem Cell Transplant for Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia [Phase 2]

  Phase 2 clinical trial evaluating Treo/Flu/TBI with donor stem cell transplant for myelodysplastic syndrome or acute myeloid leukemia.

• CLINICAL_TRIALS trial_result · 2018-05-11
  Clinical Trial Update: Azacitidine and Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia [Phase 2]

  Phase 2 trial evaluating azacitidine plus arsenic trioxide in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia; t…

• CLINICAL_TRIALS trial_result · 2018-03-21
  Clinical Trial Update: Ipilimumab in Treating Patients With Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia [Phase 1]

  A Phase 1 study evaluating ipilimumab in patients with relapsed or refractory high-risk myelodysplastic syndrome or acute myeloid leukemia h…

• CLINICAL_TRIALS trial_result · 2017-12-19
  Clinical Trial Update: A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML) [Phase 1, Phase 2]

  Clinical trial update for HDC/IL-2 treatment in chronic myelomonocytic leukemia (CMML) across Phase 1 and Phase 2.

• CLINICAL_TRIALS trial_result · 2017-12-06
  Clinical Trial Update: MEK Inhibitor MEK162, Idarubicin, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]

  A Phase 1 trial evaluating a MEK inhibitor (MEK162) in combination with idarubicin and cytarabine for adults with relapsed or refractory acu…

• CLINICAL_TRIALS trial_result · 2017-11-17
  Clinical Trial Update: Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes [NA]

  This clinical trial evaluated a combination of idarubicin, cytarabine, and pravastatin sodium in adults with acute myeloid leukemia or myelo…

• CLINICAL_TRIALS trial_result · 2017-10-19
  Clinical Trial Update: Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm [Phase 2]

  Phase 2 clinical trial evaluating the combination of Clofarabine, Cytarabine, and Filgrastim in adults with newly diagnosed acute myeloid le…