Myelomonocytic Leukemia

CLINICAL_TRIALS trial_result · 2025-10-01

Clinical Trial Update: A Study of JNJ-74856665 in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) [Phase 1]

Phase 1 study of JNJ-74856665 in participants with Acute Myeloid Leukemia, Myelodysplastic Syndromes, or Chronic Myelomonocytic Leukemia has…

CLINICAL_TRIALS trial_result · 2025-07-20

Clinical Trial Update: Haplo Peripheral Blood Sct In GVHD Prevention [Phase 1]

Phase 1 trial update reporting the completion of a haploidentical peripheral blood stem cell transplantation approach for the prevention of …

CLINICAL_TRIALS trial_result · 2025-07-15

Clinical Trial Update: CPX-351 as a Novel Approach for the Treatment of Older Patients With AML and MDS [Phase 2]

Phase 2 trial status update for CPX-351 in older patients with refractory or relapsed acute myeloid leukemia and myelodysplastic syndromes; …

CLINICAL_TRIALS trial_result · 2025-07-14

Clinical Trial Update: AMG 176 With Azacitidine in Subjects With Myelodysplastic Syndrome /Chronic Myelomonocytic Leukemia [Phase 1]

A Phase 1 study evaluating AMG 176 in combination with azacitidine in higher-risk myelodysplastic syndromes and chronic myelomonocytic leuke…

CLINICAL_TRIALS trial_result · 2025-06-22

Clinical Trial Update: A Study of E7820 in People With Bone Marrow (Myeloid) Cancers [Phase 2]

Phase 2 study of E7820 in people with bone marrow (myeloid) cancers, including Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Chroni…

CLINICAL_TRIALS trial_result · 2025-05-23

Clinical Trial Update: DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia [Phase 1, Phase 2]

A phase 1/2 study of DS-1594b with or without azacitidine, venetoclax, or mini-HCVD in relapsed or refractory acute myeloid leukemia or acut…

CLINICAL_TRIALS trial_result · 2025-04-22

Clinical Trial Update: Azacitidine, Venetoclax, and Trametinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Higher-Risk Myelodysplastic Syndrome [Phase 2]

Phase 2 trial evaluating a three-drug combination of azacitidine, venetoclax, and trametinib for relapsed or refractory acute myeloid leukem…

CLINICAL_TRIALS trial_result · 2025-04-02

Clinical Trial Update: Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders [Phase 1]

Phase 1 study of Veliparib with Topotecan, with or without Carboplatin, in relapsed or refractory acute leukemias, high-risk myelodysplastic…

CLINICAL_TRIALS trial_result · 2025-03-20

Clinical Trial Update: Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies [Phase 2]

This Phase 2 trial investigates reduced-intensity chemotherapy and radiation therapy before donor stem cell transplantation for various hema…

CLINICAL_TRIALS trial_result · 2025-03-19

Clinical Trial Update: Study of FF-10501-01 in Patients With Relapsed or Refractory Hematological Malignancies [Phase 1, Phase 2]

Phase 1/2 study of FF-10501-01 in relapsed or refractory hematologic malignancies has completed, with results posted. The diseases studied i…

CLINICAL_TRIALS trial_result · 2025-03-05

Clinical Trial Update: LILRB4 STAR-T Cells in the Treatment of R/R AML/CMML [Phase 1]

A Phase 1 trial evaluating LILRB4 STAR-T Cells for relapsed/refractory acute myeloid leukemia and chronic myelomonocytic leukemia has comple…

CLINICAL_TRIALS trial_result · 2025-02-14

Clinical Trial Update: IO-202 as Monotherapy and IO-202 Plus Azacitidine ± Venetoclax in Patients in AML and CMML [Phase 1]

Phase 1 trial completion reporting IO-202 as a monotherapy and IO-202 in combination with azacitidine ± venetoclax in patients with acute my…

CLINICAL_TRIALS trial_result · 2025-02-13

Clinical Trial Update: Fostamatinib for the Treatment of Lower-risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia Who Have Failed Therapy With Hypomethylating Agents [Phase 1]

Phase 1 trial of fostamatinib for lower-risk myelodysplastic syndromes or chronic myelomonocytic leukemia after failure of hypomethylating a…

CLINICAL_TRIALS trial_result · 2025-01-23

Clinical Trial Update: SGI-110 in Participants With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML) [Phase 1, Phase 2]

Clinical trial update reporting completion and posted results for SGI-110 (guadecitabine) in patients with myelodysplastic syndromes, chroni…

CLINICAL_TRIALS trial_result · 2025-01-06

Clinical Trial Update: Tagraxofusp (SL-401) in Participants With Chronic Myelomonocytic Leukemia (CMML) and Myelofibrosis (MF) [Phase 1, Phase 2]

A Phase 1/2 trial of Tagraxofusp (SL-401) in chronic myelomonocytic leukemia and myelofibrosis has completed with results posted (January 20…

CLINICAL_TRIALS trial_result · 2024-09-19

Clinical Trial Update: IDH2-Post-Allo-Trial for Patients with IDH2-mut Myeloid Neoplasms After Allo-SCT [Phase 2]

This is a Phase 2 trial evaluating IDH2-mutant myeloid neoplasms after allogeneic stem cell transplantation. The study status is completed.

CLINICAL_TRIALS trial_result · 2024-09-05

Clinical Trial Update: A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems [Phase 1]

Takeda announced results from a Phase 1 study of pevonedistat in people with blood cancers and solid tumors who also have kidney or liver im…

CLINICAL_TRIALS trial_result · 2024-08-02

Clinical Trial Update: Effect of Food on Blood Levels of ASTX727 [Phase 1]

Phase 1 trial evaluating the impact of food on plasma levels of ASTX727 (decitabine/cedazuridine) in patients with myelodysplastic syndromes…

CLINICAL_TRIALS trial_result · 2024-07-17

Clinical Trial Update: Tipifarnib in Subjects With Chronic Myelomonocytic Leukemia, Other MDS/MPN, and Acute Myeloid Leukemia [Phase 2]

This Phase 2 trial evaluated tipifarnib in patients with chronic myelomonocytic leukemia and other myelodysplastic/myeloproliferative neopla…

CLINICAL_TRIALS trial_result · 2024-07-01

Clinical Trial Update: Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML [Phase 3]

Phase 3 study comparing ASTX727 (cedazuridine/decitabine) versus intravenous decitabine in myelodysplastic syndromes, chronic myelomonocytic…

CLINICAL_TRIALS trial_result · 2024-05-28

Clinical Trial Update: Evaluating in Vivo AZA Incorporation in Mononuclear Cells Following Vidaza or CC486 [Phase 2]

A Phase 2 trial completed evaluating in vivo azacitidine incorporation in mononuclear cells after Vidaza or CC-486 treatment in patients wit…

CLINICAL_TRIALS trial_result · 2024-05-24

Clinical Trial Update: Classical Monocyte Kinetics in Chronic Myelomonocytic Leukemia [NA]

A clinical trial investigating classical monocyte kinetics in chronic myelomonocytic leukemia has completed.

CLINICAL_TRIALS trial_result · 2024-05-21

Clinical Trial Update: IGF-MTX Conjugate in the Treatment of Myelodysplastic Syndrome [Phase 1, Phase 2]

Phase 1/2 clinical trial of IGF-MTX Conjugate for myelodysplastic syndromes and related hematologic conditions has been terminated, with res…

CLINICAL_TRIALS trial_result · 2024-05-14

Clinical Trial Update: Glutaminase Inhibitor CB-839 and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndrome [Phase 1, Phase 2]

This update reports completion of a Phase 1/2 study evaluating the glutaminase inhibitor Telaglenastat (CB-839) in combination with azacitid…

CLINICAL_TRIALS trial_result · 2024-04-02

Clinical Trial Update: Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia [Phase 2]

Phase 2 trial update evaluating topotecan hydrochloride and carboplatin with or without veliparib for advanced myeloproliferative disorders …

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