Chronic Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2016-04-11Clinical Trial Update: Metabolic Outcomes in Patients Receiving Tyrosine Kinase Inhibitor (TKI) Therapy With Dasatinib or Nilotinib
A completed clinical trial evaluating metabolic outcomes in patients with chronic myeloid leukemia treated with the tyrosine kinase inhibito…
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FDA label_change · 2016-04-04FDA Approved: BOSULIF — Supplemental Application (Pfizer Laboratories Div Pfizer Inc)
FDA approved a supplemental application for Bosulif (bosutinib) submitted by Pfizer Laboratories Div Pfizer Inc.
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FDA approval · 2016-03-23FDA Approved: DROXIA — Supplemental Application (Waylis Therapeutics LLC)
FDA approved a supplemental application for DROXIA (hydroxyurea) filed by Waylis Therapeutics LLC.
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CLINICAL_TRIALS trial_result · 2016-03-03Clinical Trial Update: Safety and Efficacy of Nilotinib in Newly Diagnosed Chronic Myeloid Leukemia Patients [Phase 3]
Phase 3 study evaluating the safety and efficacy of nilotinib in newly diagnosed chronic myeloid leukemia; results were posted for this comp…
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CLINICAL_TRIALS trial_result · 2016-02-26Clinical Trial Update: Safety and Efficacy of POL6326 for Mobilization/Transplant of Sibling Donor in Patients With Hematologic Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating safety and efficacy of POL6326 for mobilization and transplant in hematologic malignancies has completed…
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CLINICAL_TRIALS trial_result · 2016-02-24Clinical Trial Update: Radotinib Versus Imatinib in Newly Diagnosed Philadelphia Chromosome and Chronic Myeloid Leukemia Chronic Phase Patients [Phase 3]
A Phase 3 randomized trial comparing radotinib to imatinib in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid…
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CLINICAL_TRIALS trial_result · 2016-02-23Clinical Trial Update: Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia [Phase 1]
Phase 1 study of Terameprocol (EM-1421) in leukemia was terminated; no efficacy results were reported in this update.
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CLINICAL_TRIALS withdrawal · 2016-02-17Clinical Trial Update: Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced Phase CML or Philadelphia Chromosome Positive ALL [Phase 2, Phase 3]
The trial studying dasatinib in imatinib-resistant or intolerant chronic myeloid leukemia or Philadelphia chromosome‑positive acute lymphobl…
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CLINICAL_TRIALS withdrawal · 2016-02-17Clinical Trial Update: Study of Ipilimumab and Dasatinib Combination Therapy in Patients With Chronic or Accelerated Chronic Myeloid Leukemia [Phase 1]
A Phase 1 trial evaluating the combination of ipilimumab and dasatinib in patients with chronic or accelerated chronic myeloid leukemia has …
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CLINICAL_TRIALS withdrawal · 2016-02-17Clinical Trial Update: Phase I Study of Dasatinib (BMS-354825) and Imatinib in Subjects With Chronic Myeloid Leukemia in Chronic Phase [Phase 1]
A Phase I trial evaluating dasatinib in combination with imatinib for chronic myeloid leukemia in chronic phase has been withdrawn.
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CLINICAL_TRIALS trial_result · 2016-02-08Clinical Trial Update: CMR Rate of Newly Diagnosed CML-CP Patients Treated With Nilotinib [Phase 4]
Phase 4 trial update reports the rate of complete molecular response (CMR) in newly diagnosed chronic myeloid leukemia patients treated with…
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CLINICAL_TRIALS trial_result · 2016-01-27Clinical Trial Update: A Pharmacokinetic (PK) Study of Nilotinib in Pediatric Patients With Philadelphia Chromosome-positive (Ph+) Chronic Myelogenous Leukemia (CML) or Acute Lymphoblastic Leukemia (ALL) [Phase 1]
Phase 1 pharmacokinetic study of nilotinib in pediatric patients with Philadelphia chromosome–positive CML or ALL; study completed with resu…
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CLINICAL_TRIALS trial_result · 2016-01-22Clinical Trial Update: Long-term Safety of Dasatinib in Patients With Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia [Phase 2]
This clinical trial update reports long-term safety data for dasatinib in patients with chronic myeloid leukemia and Philadelphia chromosome…
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CLINICAL_TRIALS trial_result · 2016-01-20Clinical Trial Update: Therapy of Early Chronic Phase CML With Gleevec [Phase 2]
Phase 2 trial evaluating Gleevec (imatinib) in early chronic phase chronic myeloid leukemia; the study has completed.
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CLINICAL_TRIALS trial_result · 2015-12-31Clinical Trial Update: Alloreactive Haploidentical Natural Killer (NK) Cells With Busulfan and Fludarabine/ATG [Phase 2]
Phase 2 clinical trial evaluating alloreactive haploidentical natural killer cells with busulfan and fludarabine/ATG conditioning in leukemi…
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CLINICAL_TRIALS trial_result · 2015-12-16Clinical Trial Update: An Open-Label, Multicenter, Expanded Access Study of Oral AMN 107 in Adult Patients With Imatinib (Glivec®/Gleevec®_ - Resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase [NA]
Open-label, multicenter expanded-access study of nilotinib (AMN-107) in adults with imatinib-resistant or -intolerant chronic myeloid leukem…
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CLINICAL_TRIALS trial_result · 2015-12-14Clinical Trial Update: HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignancies [Phase 2]
Phase 2 trial evaluating HLA-nonidentical stem cell and natural killer cell transplantation in children under two with hematologic malignanc…
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CLINICAL_TRIALS trial_result · 2015-12-09Clinical Trial Update: Safety and Efficacy of Nilotinib vs. Imatinib in the Treatment of Newly Diagnosed Chinese Ph+ CML-CP Patients [Phase 3]
This Phase 3 trial compares nilotinib to imatinib as first-line therapy for Philadelphia chromosome-positive chronic myeloid leukemia in Chi…
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CLINICAL_TRIALS trial_result · 2015-12-08Clinical Trial Update: Nuvigil in Treatment of Cancer-Related Fatigue in Chronic Myeloid Leukemia Patients [NA]
A terminated MD Anderson clinical trial evaluated armodafinil (Nuvigil) for cancer-related fatigue in chronic myeloid leukemia patients, wit…
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FDA approval · 2015-12-03FDA Approved: IMATINIB MESYLATE — Original Application (BluePoint Laboratories)
FDA approved the original application for Imatinib Mesylate from BluePoint Laboratories (ANDA078340), authorizing a generic version of the c…
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FDA approval · 2015-12-01FDA Approved: ICLUSIG — Supplemental Application (Takeda Pharmaceuticals America, Inc.)
FDA approved a supplemental application for ICLUSIG (ponatinib hydrochloride) submitted by Takeda Pharmaceuticals America, Inc., under NDA 2…
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CLINICAL_TRIALS trial_result · 2015-11-26Clinical Trial Update: PEG Interferon Alpha 2B and Low-Dose Ara-C in Early Chronic Phase CML [Phase 1]
This is a Phase 1 study evaluating pegylated interferon alfa-2b in combination with low-dose cytarabine for early-phase chronic myeloid leuk…
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CLINICAL_TRIALS trial_result · 2015-11-16Clinical Trial Update: Randomized Phase Lll Study of Imatinib Dose Optimization vs Nilotinib in CML Patients With Suboptimal Response to Imatinib [Phase 3]
A randomized phase III trial compared imatinib dose optimization versus nilotinib in chronic myeloid leukemia patients with suboptimal respo…
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CLINICAL_TRIALS trial_result · 2015-11-13Clinical Trial Update: Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies [Phase 2]
Phase 2 study evaluating a triple regimen of vorinostat, tacrolimus, and methotrexate to prevent graft-versus-host disease after allogeneic …
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FDA approval · 2015-10-15FDA Approved: TASIGNA — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for Tasigna (nilotinib) submitted by Novartis Pharmaceuticals Corporation. The approval pertains to …