Chronic Lymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2016-09-26Clinical Trial Update: Combination Chemotherapy, Total-Body Irradiation, and Alemtuzumab in Treating Patients Undergoing an Autologous Stem Cell Transplant for Stage I, Stage II, Stage III, or Stage IV Chronic Lymphocytic Leukemia [Phase 2]
Phase 2 clinical trial evaluating a regimen of combination chemotherapy, total-body irradiation, and alemtuzumab in patients undergoing auto…
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CLINICAL_TRIALS trial_result · 2016-09-26Clinical Trial Update: Combination Chemotherapy With or Without G-CSF in Treating Patients With Relapsed Chronic Lymphocytic Leukemia [Phase 3]
A Phase 3 trial comparing combination chemotherapy with versus without G-CSF in relapsed chronic lymphocytic leukemia has been terminated.
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FDA approval · 2016-09-21FDA Approved: ZYDELIG — Supplemental Application (Gilead Sciences, Inc.)
The FDA approved a supplemental application for ZYDELIG (idelalisib) filed by Gilead Sciences, Inc.
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CLINICAL_TRIALS trial_result · 2016-09-19Clinical Trial Update: Ofatumumab Induction and Maintenance in Elderly Patients With Poor Risk CLL in the Context of Allogeneic Transplantation [Phase 2]
Phase 2 trial evaluating induction and maintenance with ofatumumab in elderly patients with poor-risk chronic lymphocytic leukemia undergoin…
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CLINICAL_TRIALS trial_result · 2016-09-12Clinical Trial Update: Single Treatment With FT1050 of an Ex-vivo Modulated Umbilical Cord Blood Unit [Phase 1]
This update reports the completion of a Phase 1 trial evaluating a single treatment with FT1050, an ex-vivo modulated umbilical cord blood u…
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CLINICAL_TRIALS research · 2016-09-07Clinical Trial Update: a Clinical Research of Sequential CAR-T Bridging HSCT in the Treatment of Relapse/Refractory B-cell Malignancies [Phase 2]
A Phase 2 clinical trial update evaluating sequential CAR-T cell therapy followed by hematopoietic stem cell transplantation for relapse/ref…
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CLINICAL_TRIALS trial_result · 2016-08-23Clinical Trial Update: Fludarabine, Cyclophosphamide, and Rituximab - High Dose Frontline [Phase 2]
Phase 2 trial evaluating high-dose frontline fludarabine, cyclophosphamide, and rituximab in chronic lymphocytic leukemia; results posted af…
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CLINICAL_TRIALS research · 2016-08-17Clinical Trial Update: Institut Paoli Calmettes Chronic Lymphatic Leukemia Database
Clinical trial update shows Institut Paoli-Calmettes is running a database project for Chronic Lymphocytic Leukemia (B-cell) with recruitmen…
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CLINICAL_TRIALS trial_result · 2016-08-03Clinical Trial Update: Anti-CD19 Chimeric Antigen Receptor (CAR)-Transduced T Cell Therapy for Patients With B Cell Malignancies [Phase 1]
This Phase 1 clinical trial update reports on an anti-CD19 CAR-T cell therapy being tested in patients with B cell malignancies, including c…
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CLINICAL_TRIALS trial_result · 2016-08-01Clinical Trial Update: Study Evaluating the Efficacy and Safety of PCAR-019 in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma [Phase 1, Phase 2]
Clinical trial update for PCAR-019 evaluating efficacy and safety in CD19-positive relapsed or refractory leukemia and lymphoma across Phase…
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CLINICAL_TRIALS trial_result · 2016-07-28Clinical Trial Update: Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia [Phase 3]
A Phase 3 trial comparing frontline alemtuzumab (Campath, MabCampath) to chlorambucil in progressive B-cell chronic lymphocytic leukemia has…
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CLINICAL_TRIALS trial_result · 2016-07-26Clinical Trial Update: Hydroxychloroquine in Untreated B-CLL Patients [Phase 2]
A Phase 2 trial evaluating hydroxychloroquine in untreated B-cell chronic lymphocytic leukemia was terminated, with results posted in 2016.
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CLINICAL_TRIALS withdrawal · 2016-07-26Clinical Trial Update: A Study of Duvelisib and Venetoclax in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Indolent or Aggressive Non-Hodgkin Lymphoma, Who Have Not Previously Received a Bcl-2 or PI3K Inhibitor [Phase 1]
A Phase 1 study of the combination of duvelisib and venetoclax in relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lym…
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CLINICAL_TRIALS trial_result · 2016-07-25Clinical Trial Update: Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemia [Phase 3]
Phase 3 trial evaluating ofatumumab added to fludarabine-cyclophosphamide versus fludarabine-cyclophosphamide in relapsed chronic lymphocyti…
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CLINICAL_TRIALS trial_result · 2016-07-20Clinical Trial Update: Fludarabine and Monoclonal Antibody Therapy in Treating Patients With Untreated B-cell Chronic Lymphocytic Leukemia [Phase 2]
Phase 2 trial evaluating the combination of fludarabine with a monoclonal antibody for untreated B-cell chronic lymphocytic leukemia has com…
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CLINICAL_TRIALS research · 2016-07-20Clinical Trial Update: Observational Study in Participants With Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) in Latin America
This is a completed observational study conducted in Latin America evaluating participants with chronic lymphocytic leukemia, multiple myelo…
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CLINICAL_TRIALS trial_result · 2016-07-18Clinical Trial Update: Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders [Phase 2]
A Phase 2 trial testing nonmyeloablative allogeneic stem cell transplantation from HLA-matched unrelated donors for multiple hematologic dis…
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CLINICAL_TRIALS trial_result · 2016-07-13Clinical Trial Update: Safety, Tolerability and Efficacy of A6 in Patients With Chronic Lymphocytic Leukemia (CLL) [Phase 2]
A Phase 2 trial evaluating the investigational drug A6 for chronic lymphocytic leukemia and small lymphocytic lymphoma has been terminated.
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CLINICAL_TRIALS research · 2016-07-12Clinical Trial Update: Peptide-drug-conjugates for Personalized, Targeted Therapy of Chronic Lymphocytic Leukemia
This document provides an update on a clinical trial investigating peptide-drug-conjugates for personalized, targeted therapy in chronic lym…
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CLINICAL_TRIALS trial_result · 2016-07-11Clinical Trial Update: Study of IPI-145 in Combination With Rituximab or Bendamustine/Rituximab in Hematologic Malignancies [Phase 1]
Phase 1 study of idelalisib (IPI-145) in combination with Rituximab or Bendamustine/Rituximab in hematologic malignancies has completed.
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CLINICAL_TRIALS trial_result · 2016-07-06Clinical Trial Update: Fludarabine Followed by Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia [Phase 2]
This Phase 2 trial evaluates sequencing fludarabine followed by alemtuzumab in patients with chronic lymphocytic leukemia, and the study has…
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CLINICAL_TRIALS trial_result · 2016-07-06Clinical Trial Update: Ribomustin in the First Line Therapy of Chronic Lymphocytic Leukemia
This document reports on a completed clinical trial evaluating Ribomustin (bendamustine) as first-line therapy for chronic lymphocytic leuke…
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CLINICAL_TRIALS trial_result · 2016-06-28Clinical Trial Update: Akt Inhibitor MK2206, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 1, Phase 2]
Phase 1/2 trial of Akt inhibitor MK2206 combined with bendamustine and rituximab in relapsed CLL or small lymphocytic lymphoma has completed…
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CLINICAL_TRIALS trial_result · 2016-06-24Clinical Trial Update: A Study of Obinutuzumab (GA101; RO5072759) in Combination With Chemotherapy in Participants With Previously Untreated Chronic Lymphocytic Leukemia (CLL) (GALTON) [Phase 1]
This clinical trial update reports Phase 1 results for obinutuzumab in combination with chemotherapy in previously untreated chronic lymphoc…
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FDA approval · 2016-06-23FDA Approved: BENDEKA — Supplemental Application (Teva Pharmaceuticals USA, Inc.)
FDA approved a supplemental application for Bendeka (bendamustine hydrochloride) submitted by Teva Pharmaceuticals USA, Inc., indicating reg…