Chronic Lymphocytic Leukemia
📧 Sign up to get email alerts when something new happens for Chronic Lymphocytic Leukemia.
Sign up freeTop drugs studied for this disease
-
CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: A Global Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL. [Phase 3]
A Phase 3 global trial evaluating Lisaftoclax (APG-2575) in combination with acalabrutinib versus immunochemotherapy for newly diagnosed chr…
-
CLINICAL_TRIALS research · 2024-05-28Clinical Trial Update: ObinutuzuMab AtezOlizumab and VenetocLax in RichTer transfOrmation [Phase 2]
Phase 2 trial evaluating a triple therapy of obinutuzumab, atezolizumab, and venetoclax for Richter transformation in chronic lymphocytic le…
-
CLINICAL_TRIALS trial_result · 2024-05-21Clinical Trial Update: A Study to Assess Safety of ImbruvicaTM in Indian Participants With Chronic Lymphocytic Leukemia or Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy or Chronic Lymphocytic Leukemia With 17p Deletion [Phase 4]
Phase 4 safety study of ibrutinib (Imbruvica) in Indian participants with chronic lymphocytic leukemia or mantle cell lymphoma who have rece…
-
CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)
This clinical trial update from the University of Haifa examines the risks and clinical consequences of low-count monoclonal B-cell lymphocy…
-
CLINICAL_TRIALS trial_result · 2024-05-09Clinical Trial Update: Sequential Regimen of Bendamustine-Debulking Followed by CAL-101 and GA101-Induction and -Maintenance in CLL (CLL2-BCG) [Phase 2]
Phase 2 trial in chronic lymphocytic leukemia evaluating a sequential regimen of bendamustine debulking followed by CAL-101 (idelalisib) and…
- Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
-
CLINICAL_TRIALS trial_result · 2024-05-09Clinical Trial Update: Biological and Clinical Efficacy of Shingrix in Patients With CLL [NA]
Registry entry describing a trial to assess the biological and clinical efficacy of Shingrix in patients with chronic lymphocytic leukemia a…
-
CLINICAL_TRIALS research · 2024-05-09Clinical Trial Update: A Single Arm Study of Acalabrutinib Conbimed With Obinutuzumab in Chinese Patients With Previously Untreated CLL [NA]
A single-arm clinical trial is evaluating acalabrutinib in combination with obinutuzumab in Chinese patients with previously untreated chron…
-
CLINICAL_TRIALS research · 2024-05-08Clinical Trial Update: Familial B-cell Lymphoproliferative Disorders
Clinical trial update from the University of Haifa on familial B-cell lymphoproliferative disorders, including monoclonal B-cell lymphocytos…
-
CLINICAL_TRIALS trial_result · 2024-05-07Clinical Trial Update: Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia [Phase 3]
Phase 3 trial comparing Ublituximab + TGR-1202 versus Obinutuzumab + Chlorambucil in untreated and previously treated chronic lymphocytic le…
-
CLINICAL_TRIALS trial_result · 2024-05-03Clinical Trial Update: Trial of Haploidentical Stem Cell Transplantation for Haematological Cancers [Phase 2]
A Phase 2 clinical trial update on haploidentical stem cell transplantation for multiple hematologic cancers, with the study status reported…
-
CLINICAL_TRIALS research · 2024-05-03Clinical Trial Update: Allogeneic CARCIK-CD19 in Adults/Pediatric B-cell NHL or Chronic Lymphocytic Leukemia [Phase 1, Phase 2]
Clinical trial update for allogeneic CARCIK-CD19 in adults and children with B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia; Ph…
-
CLINICAL_TRIALS trial_result · 2024-05-02Clinical Trial Update: Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma [Phase 1]
A Phase 1 study evaluating the safety and preliminary efficacy of the combination of duvelisib and nivolumab in patients with Richter syndro…
-
CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: A Phase I Safety, PK and PD Study of KW-2478 in Patients With Multiple Myeloma, Chronic Lymphocytic Leukaemia or B-cell Non-Hodgkin's Lymphoma [Phase 1]
A Phase I safety, pharmacokinetic and pharmacodynamic study of KW-2478 in patients with multiple myeloma, chronic lymphocytic leukemia, or B…
-
CLINICAL_TRIALS withdrawal · 2024-04-19Clinical Trial Update: Study to Assess the Efficacy and Safety of Ublituximab in Combination With Umbralisib and Venetoclax Compared to Ublituximab in Combination With Umbralisib in Subjects With CLL (ULTRA-V) [Phase 2, Phase 3]
Clinical trial ULTRA-V (Ublituximab with Umbralisib ± Venetoclax) in CLL/SLL has been terminated, with results posted.
-
CLINICAL_TRIALS trial_result · 2024-04-12Clinical Trial Update: Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
Phase 2 trial investigating curcumin and cholecalciferol in previously untreated stage 0-II chronic lymphocytic leukemia or small lymphocyti…
-
CLINICAL_TRIALS withdrawal · 2024-04-02Clinical Trial Update: A Study to Compare the Efficacy and Safety of Lisocabtagene Maraleucel vs Investigator's Choice Options in Adult Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, Whose Disease Has Failed Treatment With Both BTKi and BCL2i Therapies [Phase 3]
Phase 3 trial comparing lisocabtagene maraleucel vs investigator's choice in adult relapsed/refractory CLL/SLL has been withdrawn.
-
CLINICAL_TRIALS trial_result · 2024-04-02Clinical Trial Update: Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer [Phase 2]
Phase 2 study evaluating a conditioning regimen of fludarabine phosphate, cyclophosphamide, and total body irradiation followed by donor ste…
-
CLINICAL_TRIALS trial_result · 2024-03-25Clinical Trial Update: Umbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells for B Lymphoid Malignancies [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating Umbilical Cord Blood-derived CAR-engineered NK cells for B lymphoid malignancies has completed with po…
-
CLINICAL_TRIALS trial_result · 2024-03-20Clinical Trial Update: Nivolumab and Ibrutinib in Treating Patients With Relapsed, Refractory, or High-Risk Untreated Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Richter Transformation [Phase 2]
Phase 2 trial evaluating nivolumab and ibrutinib in relapsed/refractory or high-risk untreated chronic lymphocytic leukemia, small lymphocyt…
-
FDA approval · 2024-02-26FDA Approved: BENDAMUSTINE HYDROCHLORIDE — Supplemental Application (Baxter Healthcare Corporation)
FDA approved a supplemental application for bendamustine hydrochloride (Baxter Healthcare Corporation) under NDA 216078.
-
FDA approval · 2024-02-22FDA Approved: IMBRUVICA — Supplemental Application (Pharmacyclics LLC)
The FDA approved a supplemental application for IMBRUVICA (ibrutinib) submitted by Pharmacyclics LLC.
-
FDA approval · 2024-02-08FDA Approved: CAMPATH — Supplemental Application (Genzyme Corporation)
FDA approved a supplemental application for CAMPATH (alemtuzumab) submitted by Genzyme Corporation.
-
FDA approval · 2024-02-08FDA Approved: VIVIMUSTA — Supplemental Application (Azurity Pharmaceuticals, Inc.)
The FDA approved a supplemental application for VIVIMUSTA (bendamustine hydrochloride) filed by Azurity Pharmaceuticals, Inc., to update/exp…
-
CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant [Phase 1]
Phase 1 trial evaluating the CMV-MVA Triplex vaccine given to stem cell donors to prevent cytomegalovirus viremia in recipients of allogenei…
-
CLINICAL_TRIALS trial_result · 2024-01-22Clinical Trial Update: Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors [EARLY_Phase 1]
Early-phase trial assessing serologic response to SHINGRIX in patients with CLL or WM treated with BTK inhibitors; completed with results po…