Chronic Lymphocytic Leukemia
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CLINICAL_TRIALS trial_result · 2024-08-02Clinical Trial Update: Immune Response to SARS-CoV-2 (COVID-19) Vaccines in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
A terminated clinical trial update investigates immune responses to SARS-CoV-2 vaccines in patients with chronic lymphocytic leukemia or sma…
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CLINICAL_TRIALS trial_result · 2024-08-01Clinical Trial Update: The clonoSEQ® Watch Registry
Clinical trial update for the clonoSEQ Watch Registry sponsored by Adaptive Biotechnologies; the study status is terminated.
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia [Phase 1]
Phase 1 study assessing TG-1801 alone or with ublituximab in patients with CLL, SLL, and other B-cell lymphomas was terminated.
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CLINICAL_TRIALS research · 2024-07-29Clinical Trial Update: Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR [Phase 1, Phase 2]
A Phase 1/2 clinical trial at University Hospital Heidelberg is evaluating third-generation CD19-directed CAR T cells in relapsed or refract…
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CLINICAL_TRIALS trial_result · 2024-07-25Clinical Trial Update: A Safety and Preliminary Efficacy Study of CC-99282 in Combination With Obinutuzumab in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma [Phase 1]
Phase 1 safety and preliminary efficacy study of CC-99282 in combination with obinutuzumab in patients with relapsed or refractory chronic l…
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CLINICAL_TRIALS trial_result · 2024-07-25Clinical Trial Update: Dose-escalation Study of Oral Administration of S 55746 in Patients With Chronic Lymphocytic Leukaemia and B-Cell Non-Hodgkin Lymphoma [Phase 1]
Phase I dose-escalation study of oral S-55746 in patients with chronic lymphocytic leukemia and B-cell non-Hodgkin lymphoma completed.
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression [Phase 3]
Phase 3 trial evaluating haploidentical allogeneic peripheral blood transplantation with analysis of checkpoint immune regulator expression;…
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CLINICAL_TRIALS trial_result · 2024-07-22Clinical Trial Update: Study to Assess Safety, Tolerability and Efficacy of MB-106 in Patients With Relapsed or Refractory B-Cell NHL or CLL [Phase 1, Phase 2]
Mustang Bio's MB-106 study in relapsed or refractory B-cell lymphomas and chronic lymphocytic leukemia has been terminated, covering Phase 1…
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CLINICAL_TRIALS trial_result · 2024-07-22Clinical Trial Update: Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.
A long-term follow-up update on patients previously treated with Mustang Bio's CAR-T cell investigational product; the trial has been termin…
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CLINICAL_TRIALS trial_result · 2024-07-19Clinical Trial Update: Study of TG-1701, an Irreversible Bruton's Tyrosine Kinase Inhibitor, in Patients With B-Cell Malignancies [Phase 1]
Clinical Trial Update reports the termination of a Phase 1 study of TG-1701 in B-cell malignancies.
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CLINICAL_TRIALS trial_result · 2024-07-18Clinical Trial Update: Letermovir for the Prevention of Cytomegalovirus Reactivation in Patients With Hematological Malignancies Treated With Alemtuzumab [Phase 2]
Phase 2 trial evaluating letermovir for prevention of cytomegalovirus reactivation in patients with hematologic malignancies treated with al…
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CLINICAL_TRIALS research · 2024-07-18Clinical Trial Update: Current Status of BTKi Treatment for CLL/SLL in China
An update on a Bruton tyrosine kinase inhibitor (BTKi) trial for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in China,…
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CLINICAL_TRIALS research · 2024-07-18Clinical Trial Update: A Study to Investigate the Efficacy and Safety of MS-553 in CLL/SLL [Phase 1, Phase 2]
A Phase 1/2 study evaluating MS-553 for chronic lymphocytic leukemia and small lymphocytic lymphoma was terminated.
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CLINICAL_TRIALS trial_result · 2024-07-18Clinical Trial Update: A Study of MS-553 in Patients With Relapsed or Refractory B-cell Lymphoma [Phase 1, Phase 2]
MS-553 trial in relapsed/refractory B-cell lymphomas was terminated after Phase 1/2 studies.
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CLINICAL_TRIALS trial_result · 2024-07-16Clinical Trial Update: A Study of LOXO-305 in Chinese Participants With Blood Cancer (Including Lymphoma and Chronic Leukemia) [Phase 2]
Phase 2 clinical trial update on LOXO-305 (pirtobrutinib) in Chinese participants with B-cell malignancies, with results posted on July 16, …
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CLINICAL_TRIALS trial_result · 2024-07-10Clinical Trial Update: Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide [Phase 2]
Phase 2 haploidentical stem cell transplantation trial using post-transplant cyclophosphamide was terminated.
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: Venetoclax With High-dose Ibrutinib for CLL Progressing on Single Agent Ibrutinib [Phase 1]
A Phase 1 clinical trial evaluating the combination of venetoclax with high-dose ibrutinib in chronic lymphocytic leukemia and small lymphoc…
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CLINICAL_TRIALS research · 2024-07-05Clinical Trial Update: The Real World Study of Zanubrutinib in the Treatment of Chronic Lymphocytic Leukemia in China
Real-world study evaluating zanubrutinib for chronic lymphocytic leukemia in China; currently not recruiting.
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: Evaluate the Efficacy and Safety of TGR-1202 in Participants With Chronic Lymphocytic Leukemia Who Are Intolerant to Prior Therapy [Phase 2]
Phase 2 clinical trial update for TGR-1202 in patients with chronic lymphocytic leukemia intolerant to prior therapy; the study was terminat…
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CLINICAL_TRIALS research · 2024-07-01Clinical Trial Update: Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
This clinical trial update describes ongoing genomic analysis in patients with Chronic Lymphocytic Leukemia. The study status is active but …
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CLINICAL_TRIALS research · 2024-06-27Clinical Trial Update: A Practical Clinical Study Comparing the Fixed-cycle Regimen Containing Orelabrutinib With BTKi Monotherapy [Phase 2]
This update outlines a Phase 2 clinical trial comparing a fixed-cycle regimen including orelabrutinib with BTK inhibitor monotherapy for chr…
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CLINICAL_TRIALS research · 2024-06-26Clinical Trial Update: Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk [NA]
This clinical trial update outlines a study of immune deficiency in untreated chronic lymphocytic leukemia patients, and a search for factor…
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CLINICAL_TRIALS research · 2024-06-20Clinical Trial Update: Polymorphism of ITGA4 Gene in Chronic Lymphocytic Leukemia
A clinical trial from Sohag University investigates polymorphism of the ITGA4 gene in Chronic Lymphocytic Leukemia; the study is currently N…
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FDA label_change · 2024-06-04FDA Approved: BRUKINSA — Supplemental Application (BeOne Medicines USA, Inc.)
FDA approved a supplemental application for BRUKINSA (zanubrutinib) to update the product labeling.
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia [Phase 2]
A phase 2 trial evaluating acalabrutinib for relapsed or refractory autoimmune hemolytic anemia in patients with chronic lymphocytic leukemi…