Central Nervous System Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases [Phase 2]
Phase 2 clinical trial evaluating the combination of binimetinib and encorafenib for metastatic melanoma with CNS metastases is currently re…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Prospective Study of the Genomic Landscape of Central Nervous System Disease Secondary to Breast Cancer Utilising Cell-free DNA Derived From Cerebrospinal Fluid (CSF)
A prospective study characterizing the genomic landscape of central nervous system disease secondary to breast cancer using cell-free DNA fr…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Predictive Factors for CNS Metastases in Early Breast Cancer Using Liquid Biopsy (AKRA CŽS) [NA]
This entry notes a clinical trial evaluating predictive factors for central nervous system metastases in early breast cancer using liquid bi…
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Whole Brain Radiation Using IMRT for Patients With Brain Metastases [NA]
The clinical trial evaluating whole-brain radiation therapy using IMRT for brain metastases has completed.
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CLINICAL_TRIALS trial_result · 2024-05-07Clinical Trial Update: Atezolizumab + Pertuzumab + Trastuzumab In CNS Mets In BC [Phase 2]
Phase 2 clinical trial update investigating the triple combination of atezolizumab, pertuzumab, and trastuzumab for HER2-positive metastatic…
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CLINICAL_TRIALS trial_result · 2024-02-08Clinical Trial Update: A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastases [Phase 2]
Phase 2 trial evaluating cobimetinib in combination with atezolizumab, with/without vemurafenib, for BRAFV600 wild-type and BRAFV600 mutatio…
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CLINICAL_TRIALS trial_result · 2019-11-12Clinical Trial Update: Phase 1b/2 Trial Using Lapatinib, Everolimus and Capecitabine for Treatment of HER-2 Positive Breast Cancer With CNS Metastasis [Phase 1, Phase 2]
Phase 1b/2 trial evaluating lapatinib, everolimus, and capecitabine for HER2-positive breast cancer with CNS metastases has completed.
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CLINICAL_TRIALS withdrawal · 2016-07-27Clinical Trial Update: Collection of Cerebrospinal Fluid and Tumor Tissue in Subjects With Metastatic Melanoma and Controls
The study on collection of cerebrospinal fluid and tumor tissue in subjects with metastatic melanoma and controls has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2014-10-08Clinical Trial Update: A Pilot Study of Irinotecan in Patients With Breast Cancer and CNS Metastases [NA]
A pilot study of irinotecan for breast cancer with central nervous system metastases has been withdrawn.
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CLINICAL_TRIALS trial_result · 2014-01-28Clinical Trial Update: Sunitinib in Treating Young Patients With Refractory Solid Tumors [Phase 1]
A Phase 1 trial evaluating sunitinib in pediatric patients with refractory solid tumors, including various childhood central nervous system …
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CLINICAL_TRIALS trial_result · 2013-07-31Clinical Trial Update: Electrochemotherapy as a Palliative Treatment for Brain Metastases [Phase 1]
Phase 1 trial evaluating electrochemotherapy as palliative treatment for brain metastases has been terminated.
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CLINICAL_TRIALS trial_result · 2013-06-06Clinical Trial Update: Lapatinib in Treating Brain Metastases in Patients With Stage IV Breast Cancer and Brain Metastases [Phase 2]
A Phase 2 study sponsored by the NCI evaluated lapatinib for brain metastases in patients with stage IV HER2-positive breast cancer; the tri…