Cataplexy

• CLINICAL_TRIALS trial_result · 2025-11-13
  Clinical Trial Update: A Study to Assess the Long-term Efficacy and Safety of AXS-12 (Reboxetine) in Subjects With Narcolepsy (ENCORE) [Phase 3]

  A Phase 3 study (ENCORE) evaluating the long-term efficacy and safety of AXS-12 (reboxetine) in narcolepsy with cataplexy and excessive dayt…

• CLINICAL_TRIALS trial_result · 2025-10-02
  Clinical Trial Update: An Open Label Study of FT218 in Subjects With Narcolepsy [Phase 3]

  This open-label Phase 3 trial of FT218 in narcolepsy with cataplexy has completed, providing results on safety and efficacy in this populati…

• EMA approval · 2025-05-12
  EMA Authorised: Xyrem (sodium oxybate) — UCB Pharma Ltd

  The European Medicines Agency authorised Xyrem (sodium oxybate) for cataplexy and narcolepsy. The marketing authorization holder is UCB Phar…

• CLINICAL_TRIALS trial_result · 2025-03-19
  Clinical Trial Update: A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy [Phase 3]

  Phase 3 trial of AXS-12 (Reboxetine) in narcolepsy with cataplexy has completed.

• CLINICAL_TRIALS trial_result · 2023-08-24
  Clinical Trial Update: Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT) [Phase 2]

  Phase 2 trial evaluating reboxetine for narcolepsy with cataplexy completed; results posted.

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• CLINICAL_TRIALS trial_result · 2022-03-22
  Clinical Trial Update: Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy [Phase 3]

  Phase 3 trial update for once-nightly sodium oxybate in narcolepsy assessing excessive daytime sleepiness and cataplexy completed with poste…

• CLINICAL_TRIALS trial_result · 2017-01-31
  Clinical Trial Update: Long Term Open Label Study in Narcolepsy With BF2.649 (Pitolisant) [Phase 3]

  A Phase 3 long-term open-label study of pitolisant (BF2.649) for narcolepsy with cataplexy has completed.

• CLINICAL_TRIALS trial_result · 2017-01-25
  Clinical Trial Update: Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia

  This clinical trial update notes the completion of a study evaluating cardiovascular variability and heart rate arousal response in idiopath…

• CLINICAL_TRIALS trial_result · 2013-02-11
  Clinical Trial Update: Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespy [Phase 3]

  Phase 3 study evaluating BF2.649 with add-on Modafinil for cataplexy in narcolepsy has completed, reporting efficacy and safety findings.