Castleman Disease

• CLINICAL_TRIALS trial_result · 2026-02-20
  Clinical Trial Update: Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease [NA]

  A clinical trial update indicates a study examining the molecular basis of Castleman disease, Langerhans cell histiocytosis, and non-Langerh…

• CLINICAL_TRIALS trial_result · 2025-08-08
  Clinical Trial Update: Sirolimus in Previously Treated Idiopathic Multicentric Castleman Disease [Phase 2]

  A Phase 2 trial of sirolimus for previously treated idiopathic multicentric Castleman disease has posted results, and the study is currently…

• CLINICAL_TRIALS trial_result · 2020-06-23
  Clinical Trial Update: Tocilizumab for KSHV-Associated Multicentric Castleman Disease [Phase 2]

  Phase 2 trial of tocilizumab for KSHV-associated multicentric Castleman disease has completed with results posted.

• CLINICAL_TRIALS trial_result · 2016-11-02
  Clinical Trial Update: A Study to Provide RoActemra/Actemra (Tocilzumab) to Patients With Multicentric Castleman's Disease Who Demonstrated Benefit From Previous RoActemra/Actemra Treatment [Phase 1]

  Phase 1 trial assessing continuation of RoActemra/Actemra (tocilizumab) in patients with multicentric Castleman's disease who previously ben…

• CLINICAL_TRIALS trial_result · 2016-06-10
  Clinical Trial Update: Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors [EARLY_Phase 1]

  Early-phase 1 clinical trial update for nelfinavir in gammaherpesvirus-related tumors, noting termination of the study despite investigation…

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• CLINICAL_TRIALS trial_result · 2014-07-01
  Clinical Trial Update: A Safety and Efficacy Study of CNTO 328 in Patients With B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Disease [Phase 1]

  This document reports the completion of a Phase 1 safety and efficacy study of CNTO-328 (siltuximab) in patients with B-cell non-Hodgkin lym…

• CLINICAL_TRIALS trial_result · 2013-02-04
  Clinical Trial Update: Suramin in Treating Patients With Refractory or Relapsed Multiple Myeloma or Castleman's Disease [Phase 2]

  Phase 2 trial evaluating suramin for refractory or relapsed multiple myeloma or Castleman's disease has completed.

• CLINICAL_TRIALS trial_result · 2011-06-15
  Clinical Trial Update: Dose-escalation Study of Oral CX-4945 [Phase 1]

  Phase 1 dose-escalation study of CX-4945 in patients with various cancers is underway, including breast cancer, inflammatory breast cancer, …