Calcific Aortic Valve Disease
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease With Mild to Moderate Aortic Stenosis (EVOID-AS) [Phase 2, Phase 3]
A Phase 2/3 study of evogliptin (DA-1229) for calcific aortic valve disease with mild-to-moderate aortic stenosis has been suspended.
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR [NA]
This ClinicalTrials.gov entry describes the PROGRESS study comparing clinical surveillance versus transcatheter aortic valve replacement (TA…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Exploration of Manidipine to Reverse Aortic Valve Calcification [Phase 2]
Phase 2 clinical trial exploring whether manidipine can reverse calcific aortic valve disease; study status not yet recruiting.
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy of PCSK-9 Inhibitors in Delaying the Progression of Calcified Aortic Valve Disease [EARLY_Phase 1]
An early-phase, multicenter randomized trial evaluating whether PCSK-9 inhibitors can slow the progression of calcific aortic valve disease …
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CLINICAL_TRIALS research · 2024-05-09Clinical Trial Update: Effect of PCSK9 Inhibitors on Calcific Aortic Valve Stenosis [Phase 3]
A Phase 3 clinical trial is evaluating the effect of PCSK9 inhibitors on calcific aortic valve stenosis and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2023-03-03Clinical Trial Update: Clinical Study to Evaluate Efficacy and Safety of DA-1229 in Patients With CAVD [Phase 2]
Phase 2 clinical trial evaluating DA-1229 for efficacy and safety in calcific aortic valve disease has completed.
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CLINICAL_TRIALS trial_result · 2020-08-20Clinical Trial Update: Randomized, Open-label Trial of Inhibitory Effect of Evogliptin on Progression of CAVD [Phase 4]
A randomized, open-label Phase 4 trial evaluating the inhibitory effect of evogliptin on progression of calcific aortic valve disease (CAVD)…
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CLINICAL_TRIALS research · 2017-05-09Clinical Trial Update: Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD
This clinical trial update investigates the prevalence and significance of mutations in NaPi transporter genes in the development of calcifi…