Beta-thalassemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2015-09-29Clinical Trial Update: Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia [Phase 1]
A Phase 1 safety and pharmacokinetic study of escalating doses of SP-420, an iron chelator, in patients with beta-thalassemia was terminated…
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CLINICAL_TRIALS trial_result · 2015-06-03Clinical Trial Update: Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload [Phase 2]
Phase 2 safety and pharmacodynamic study of an oral iron chelator given for 6 months in patients with transfusional iron overload and beta-t…
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CLINICAL_TRIALS trial_result · 2015-05-27Clinical Trial Update: Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron Overload [Phase 2]
Phase 2 trial assessing safety, efficacy, and pharmacokinetics of an oral iron chelator administered for one year in pediatric patients with…
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CLINICAL_TRIALS trial_result · 2015-03-05Clinical Trial Update: Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-Thalassemia [Phase 1, Phase 2]
The document reports the completion of a Phase 1/2 iron balance study evaluating deferoxamine (DFO) and GT56-252 in transfusional iron overl…
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CLINICAL_TRIALS trial_result · 2015-01-14Clinical Trial Update: Efficacy and Safety of Efficacy and Safety of Continued Iron Chelation Therapy In Poly-transfused Thalassemia Patients With Low Serum Ferritin (< 500 ng/ml) [NA]
Clinical trial update assessing the efficacy and safety of continued iron chelation therapy in poly-transfused beta-thalassemia patients wit…
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CLINICAL_TRIALS trial_result · 2014-12-30Clinical Trial Update: Evaluating the Safety and Effectiveness of Mozobil Mobilization in Adults With Beta-Thalassemia Major [NA]
This clinical trial update confirms the completed study evaluating the safety and effectiveness of Mozobil (plerixafor) mobilization in adul…
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CLINICAL_TRIALS trial_result · 2014-01-14Clinical Trial Update: Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac Diseases [Phase 2]
Phase 2 trial comparing a combination therapy to a single-drug therapy in cardiovascular disease patients was terminated, with results poste…
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CLINICAL_TRIALS trial_result · 2013-11-26Clinical Trial Update: Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis [Phase 2]
Phase 2 trial evaluating subcutaneous desferrioxamine for transfusional iron overload has completed, including patients with beta-thalassemi…
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CLINICAL_TRIALS trial_result · 2013-05-27Clinical Trial Update: Effect of Metoprolol on Thalassemia Cardiomyopathy [Phase 2, Phase 3]
A completed Phase 2/3 clinical trial evaluated metoprolol for beta-thalassemia cardiomyopathy.
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CLINICAL_TRIALS trial_result · 2013-03-07Clinical Trial Update: The Change of Coagulation Markers in Children With β-thalassemia Disease After Stem Cell Transplantation
This completed clinical trial update reports on changes in coagulation markers in children with beta-thalassemia after hematopoietic stem ce…
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CLINICAL_TRIALS trial_result · 2012-05-15Clinical Trial Update: Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E Patients [NA]
A completed clinical trial evaluated the effect of an antioxidant cocktail in patients with beta-thalassemia/Hb E.
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CLINICAL_TRIALS trial_result · 2012-04-19Clinical Trial Update: Safety & Efficacy of ICL670 vs. Deferoxamine in Beta-thalassemia Patients With Iron Overload Due to Blood Transfusions [Phase 3]
Phase 3 trial comparing ICL670 to Deferoxamine in beta-thalassemia patients with transfusion-related iron overload has completed, reporting …
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CLINICAL_TRIALS trial_result · 2012-02-10Clinical Trial Update: Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron Overload [Phase 1]
Phase 1 safety and pharmacokinetic study evaluating escalating doses of an investigational iron chelator in patients with Transfusional Iron…
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FDA approval · 2011-08-10FDA Approved: EXJADE — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for EXJADE (deferasirox) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2011-05-20Clinical Trial Update: Phase 1/2 Study of HQK-1001 in Patients With Beta Thalassemia [Phase 1, Phase 2]
A Phase 1/2 study of HQK-1001 in patients with beta-thalassemia has completed.
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CLINICAL_TRIALS research · 2010-03-24Clinical Trial Update: Prevalence Of Microalbuminuria Among Children Suffering From Sickle Cell Nephropathy and Sickle Cell/Beta-Thalassemia
A clinical trial update assessing how common microalbuminuria is among children with sickle cell nephropathy and sickle cell/beta-thalassemi…
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FDA approval · 2010-01-28FDA Approved: EXJADE — Supplemental Application (Novartis Pharmaceuticals Corporation)
The FDA approved a supplemental application for Exjade (deferasirox) from Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2008-08-13Clinical Trial Update: Efficacy Study of the Use of Sequential DFP-DFO Versus DFP [Phase 4]
Phase 4 efficacy trial comparing sequential DFP-DFO chelation versus deferiprone (DFP) alone in patients with beta-thalassemia major.
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CLINICAL_TRIALS trial_result · 2008-03-04Clinical Trial Update: 5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia [Phase 2]
This entry reports the completion of a Phase 2 clinical trial evaluating the combination of 5-azacytidine and phenylbutyrate for severe beta…
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CLINICAL_TRIALS trial_result · 2008-03-04Clinical Trial Update: Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia) [Phase 2]
A Phase 2 clinical trial evaluating hydroxyurea for beta-thalassemia (Cooley's anemia) has completed.