B-cell Chronic Lymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma [Phase 3]
A Phase 3 clinical trial is evaluating the efficacy, safety, and pharmacokinetics of XEMBIFY plus standard medical treatment (SMT) versus pl…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Activated T Lymphocytes Expressing CARs, Relapsed CD19+ Malignancies Post-Allo HSCT(CARPASCIO) [Phase 1]
Phase 1 trial update of CAR T cells (CARPASCIO) targeting CD19 in relapsed CD19+ malignancies after allogeneic HSCT. The study is currently …
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CLINICAL_TRIALS trial_result · 2024-03-12Clinical Trial Update: Idelalisib Post Allogeneic Hematopoietic Stem Cell Transplant (HSCT) in B Cell Derived Malignancies [Phase 1]
Phase 1 clinical trial update examining idelalisib after allogeneic HSCT in B-cell malignancies; the study is terminated with results posted…
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CLINICAL_TRIALS trial_result · 2023-06-07Clinical Trial Update: A Phase 1/2 Study To Evaluate ASN002 In Relapsed/Refractory Lymphoma And Advanced Solid Tumors [Phase 1, Phase 2]
Phase 1/2 clinical trial update for ASN002 in relapsed/refractory lymphoma and advanced solid tumors; the study status is TERMINATED with re…
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CLINICAL_TRIALS trial_result · 2023-01-31Clinical Trial Update: Dose-escalation Study of Safety of PBCAR20A in Subjects With r/r NHL or r/r CLL/SLL [Phase 1, Phase 2]
Dose-escalation early-stage trial assessing safety of PBCAR20A in relapsed/refractory Non-Hodgkin's Lymphoma and relapsed/refractory Chronic…
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CLINICAL_TRIALS trial_result · 2022-02-15Clinical Trial Update: T Cells Expressing Fully-human Anti-CD19 and Anti-CD20 Chimeric Antigen Receptors for Treating B-cell Malignancies and Hodgkin Lymphoma [Phase 1]
Phase 1 trial evaluating T cells engineered with fully-human anti-CD19 and anti-CD20 CARs for B-cell malignancies and Hodgkin lymphoma; the …
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CLINICAL_TRIALS trial_result · 2021-12-02Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Lenalidomide as Maintenance Therapy for Patients With B-Cell Chronic Lymphocytic Leukemia (CLL) Following Second Line Therapy [Phase 3]
Phase 3 clinical trial evaluating lenalidomide as maintenance therapy after second-line treatment in B-cell chronic lymphocytic leukemia com…
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CLINICAL_TRIALS trial_result · 2021-02-02Clinical Trial Update: Ibrutinib, Obinutuzumab and Venetoclax for Patients With Chronic Lymphocytic Leukemia [Phase 2]
A Phase 2 trial evaluating a combination of ibrutinib, obinutuzumab, and venetoclax in patients with B-cell chronic lymphocytic leukemia, in…
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CLINICAL_TRIALS trial_result · 2020-05-07Clinical Trial Update: Safety and Tolerability Study of PCI-32765 in B Cell Lymphoma and Chronic Lymphocytic Leukemia [Phase 2]
Phase 2 safety and tolerability study of PCI-32765 in various B-cell malignancies completed; results posted.
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CLINICAL_TRIALS trial_result · 2019-05-31Clinical Trial Update: Study of MLN8237 in Participants With Advanced Hematological Malignancies [Phase 1]
Phase 1 study of MLN8237 in advanced hematological malignancies completed; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-03-05Clinical Trial Update: Safety and Dose Ranging Study of Samalizumab to Treat Relapsing or Refractory CLL or MM [Phase 1, Phase 2]
A safety and dose-ranging study of samalizumab in relapsed or refractory CLL and multiple myeloma was terminated; results were posted in 201…
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FDA approval · 2018-11-28FDA Approved: CAMPATH — Supplemental Application (Genzyme Corporation)
The FDA approved a supplemental application for CAMPATH (alemtuzumab) from Genzyme Corporation.
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CLINICAL_TRIALS trial_result · 2018-04-27Clinical Trial Update: Treatment With Bendamustine, Ofatumumab and MethylPrednisolone in Relapsed B-CLL [Phase 2]
A Phase 2 trial of bendamustine, ofatumumab and methylprednisolone for relapsed B-cell chronic lymphocytic leukemia has been terminated.
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CLINICAL_TRIALS trial_result · 2017-11-20Clinical Trial Update: ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies [Phase 1]
A Phase 1 trial evaluated ABT-348 as a standalone therapy and in combination with azacitidine for advanced hematologic malignancies; the stu…
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CLINICAL_TRIALS trial_result · 2016-12-21Clinical Trial Update: Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial) [Phase 3]
Phase 3 trial comparing lenalidomide to chlorambucil as first-line therapy in elderly patients with B-cell chronic lymphocytic leukemia; com…
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CLINICAL_TRIALS trial_result · 2014-02-27Clinical Trial Update: Lenalidomide as Chemoprevention in Treating Patients With High-Risk, Early-Stage B-Cell Chronic Lymphocytic Leukemia [NA]
A terminated clinical trial evaluating lenalidomide as chemoprevention in high-risk, early-stage B-cell chronic lymphocytic leukemia has pos…
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CLINICAL_TRIALS trial_result · 2013-06-04Clinical Trial Update: Alvocidib, Fludarabine Phosphate, and Rituximab in Treating Patients With Lymphoproliferative Disorders or Mantle Cell Lymphoma [Phase 1]
Phase 1 study evaluating a combination of alvocidib, fludarabine phosphate, and rituximab in various B-cell lymphoproliferative disorders, w…
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CLINICAL_TRIALS trial_result · 2013-05-15Clinical Trial Update: Study of Bafetinib as Treatment for Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia (B-CLL) [Phase 2]
A Phase 2 trial of bafetinib for relapsed or refractory B-cell chronic lymphocytic leukemia conducted by CytRx has completed.
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CLINICAL_TRIALS trial_result · 2013-05-14Clinical Trial Update: Bevacizumab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia [Phase 2]
A Phase 2 trial assessed bevacizumab in patients with relapsed or refractory chronic lymphocytic leukemia; results were posted in 2013.
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CLINICAL_TRIALS trial_result · 2012-10-19Clinical Trial Update: MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma [Phase 1, Phase 2]
This clinical trial update reports on MDX-010 (ipilimumab) in treating recurrent or refractory lymphoma across multiple subtypes, with the s…
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CLINICAL_TRIALS trial_result · 2008-12-03Clinical Trial Update: Study of Subcutaneous Campath-1H in Patients With B-Cell CLL and Residual Disease After Chemotherapy [Phase 2]
A Phase 2 study evaluating subcutaneous Campath-1H (alemtuzumab) in patients with B-cell chronic lymphocytic leukemia who have residual dise…