Aplastic Anemia
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia [NA]
A completed clinical trial investigating hematopoietic stem cell transplantation for Dyskeratosis Congenita or Severe Aplastic Anemia has po…
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CLINICAL_TRIALS trial_result · 2025-04-30Clinical Trial Update: CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly [Phase 4]
A Phase 4 trial comparing CsA+ATG+AVA versus CsA+AVA in elderly patients with newly diagnosed aplastic anemia has been completed.
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies [Phase 2]
This Phase 2 trial investigates reduced-intensity chemotherapy and radiation therapy before donor stem cell transplantation for various hema…
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia [Phase 2]
A Phase II dose-escalation study evaluated the pharmacokinetics of eltrombopag in pediatric patients with previously untreated or relapsed/r…
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CLINICAL_TRIALS trial_result · 2025-02-18Clinical Trial Update: Study of CM313(SC) Injection in Subjects With Relapsed/Refractory Aplastic Anemia [Phase 1, Phase 2]
This clinical trial update concerns CM313 for relapsed/refractory aplastic anemia, a subcutaneous injection studied in Phase 1/2; the study …
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Study Assessed the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects. [Phase 2]
A Phase 2 study evaluated the safety and efficacy of eltrombopag in Chinese patients with refractory or relapsed severe aplastic anemia.
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CLINICAL_TRIALS trial_result · 2025-01-03Clinical Trial Update: Efficacy of Daratumumab to Overcome Platelet Transfusion Refractoriness in Patients with Aplastic Anemia [Phase 1]
Phase 1 trial evaluating daratumumab to overcome platelet transfusion refractoriness in patients with aplastic anemia.
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients [Phase 2]
Phase 2 trial evaluating posaconazole prophylaxis during ATG treatment in patients with aplastic anemia or myelodysplastic syndromes; the st…
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CLINICAL_TRIALS trial_result · 2024-11-07Clinical Trial Update: Hetrombopag or Placebo in Treatment-Naive Severe Aplastic Anemia [Phase 3]
A Phase 3 trial evaluating hetrombopag versus placebo in treatment-naive severe aplastic anemia has completed.
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CLINICAL_TRIALS trial_result · 2024-11-01Clinical Trial Update: Effectiveness of Early Intervention in Transfusion Independent Aplastic Anemia: a Retrospective Medical Claims Database Study
This retrospective medical claims study evaluates whether early intervention improves outcomes in transfusion-independent aplastic anemia.
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CLINICAL_TRIALS trial_result · 2024-09-25Clinical Trial Update: Cyclophosphamide Added to Standard Immunosuppressive Therapy With Herombopag as Front-line Therapy in Patients With Severe Aplastic Anemia [Phase 2]
Phase 2 clinical trial assessing adding cyclophosphamide to standard immunosuppressive therapy with herombopag as front-line treatment for s…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Extension Study of Hetrombopag in Severe Aplastic Anemia [Phase 3]
Update on a Phase 3 extension study of hetrombopag for treatment-naive severe aplastic anemia; the study is currently active but not recruit…
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CLINICAL_TRIALS trial_result · 2024-07-30Clinical Trial Update: TPO-Mimetic Use in Children for Hematopoietic Failure [EARLY_Phase 1]
An early-phase 1 pediatric trial evaluating thrombopoietin mimetics for hematopoietic failure has completed. The study enrolled children wit…
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CLINICAL_TRIALS trial_result · 2024-07-16Clinical Trial Update: Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia [Phase 2, Phase 3]
Romiplostim (AMG531) is being studied in Phase 2 and Phase 3 trials for aplastic anemia, and the trial is reported as completed.
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CLINICAL_TRIALS trial_result · 2024-03-21Clinical Trial Update: Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating a combination of sirolimus, abatacept, and mycophenolate mofetil to prevent aGraft-versus-Host Disease…
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CLINICAL_TRIALS trial_result · 2024-02-12Clinical Trial Update: Efficacy and Safety of Avatrombopag vs. Avatrombopag Combined With rhTPO in the Treatment of SAA [Phase 2]
Phase 2 trial comparing avatrombopag alone versus avatrombopag with rhTPO for anemia due to aplastic anemia, focusing on efficacy and safety…
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CLINICAL_TRIALS trial_result · 2023-12-11Clinical Trial Update: Eltrombopag Combined With Cyclosporine as First Line Therapy in Patients With Severe Acquired Aplastic Anemia [Phase 2]
A Phase 2 trial evaluating eltrombopag combined with cyclosporine as first-line therapy in adults with severe acquired aplastic anemia has c…
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CLINICAL_TRIALS trial_result · 2023-12-08Clinical Trial Update: Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly [Phase 2]
Phase 2 trial update on the combination of CsA and AVA for aplastic anemia in elderly patients, focusing on efficacy and safety.
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CLINICAL_TRIALS trial_result · 2023-11-18Clinical Trial Update: The Optimization of Conditioning Regimen for HLA Matched HSCT in SAA [Phase 4]
Phase 4 clinical trial update focusing on optimizing conditioning regimens for HLA-matched hematopoietic stem cell transplantation in severe…
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CLINICAL_TRIALS trial_result · 2023-09-26Clinical Trial Update: Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study [Phase 1, Phase 2]
Long-term follow-up update from BP-004 study (Phase 1/Phase 2) by Bellicum Pharmaceuticals; study status TERMINATED with results posted in 2…
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CLINICAL_TRIALS trial_result · 2023-08-31Clinical Trial Update: Nandrolone Decanoate in the Treatment of Telomeropathies [Phase 1, Phase 2]
Phase 1/2 clinical trial of nandrolone decanoate for telomeropathies, including aplastic anemia and bone marrow failure syndromes, has compl…
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CLINICAL_TRIALS trial_result · 2023-08-24Clinical Trial Update: Efficacy of IST Combined With TPO-RA in the Treatment of AA and Establishment of a Recurrence Prediction System [Phase 4]
Phase 4 clinical trial update evaluating efficacy of IST in combination with a TPO-RA for aplastic anemia and development of a recurrence pr…
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CLINICAL_TRIALS trial_result · 2023-08-22Clinical Trial Update: A Prospective, Randomized, Controlled Study of rhTPO in Combination With Herombopag + CsA vs Herombopag + CsA for the Treatment of Primary TD-NSAA [Phase 4]
A Phase 4 randomized trial evaluating rhTPO with Herombopag and CsA versus Herombopag and CsA for primary TD-NSAA in aplastic anemia; curren…
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CLINICAL_TRIALS trial_result · 2023-03-17Clinical Trial Update: The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia [Phase 4]
Phase 4 trial assessing immunosuppressive therapy combined with cord blood transfusion for severe aplastic anemia completed.
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CLINICAL_TRIALS trial_result · 2023-03-10Clinical Trial Update: Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia [Phase 2]
Phase 2 trial update on transplantation of partially mismatched related or matched unrelated bone marrow for refractory severe aplastic anem…