Aplastic Anemia
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia [Phase 1]
This Phase 1 trial at City of Hope is evaluating a reduced-intensity conditioning regimen of cyclophosphamide, pentostatin, and anti-thymocy…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Safety and Efficacy of the JAK1 Inhibitor Combined With Intensive Immunosuppressive Therapy in Severe Aplastic Anemia [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the safety and efficacy of a JAK1 inhibitor combined with intensive immunosuppressive therapy for s…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: UI-Romi-02; Romiplostim Added to Standard of Care for Treatment Naive and Relapsed or Refractory Severe Aplastic Anemia [Phase 2]
Phase 2 trial UI-Romi-02 investigates adding romiplostim to standard of care for treatment-naive and relapsed or refractory severe aplastic …
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: A Study of Emapalumab for Pediatric Aplastic Anemia [Phase 2]
A Phase 2 pediatric study evaluating emapalumab for aplastic anemia is currently recruiting, aiming to assess safety and potential efficacy …
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: The Safety and Efficacy of Daratumumab in Patients With Refractory Aplastic Anemia [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of daratumumab for patients with refractory aplastic anemia, focusing on safety and e…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors [Phase 2]
Phase 2 study evaluating exercise training with nicotinamide riboside (NR) supplementation to improve fitness in adolescent/young adult hema…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy [NA]
This ClinicalTrials.gov entry describes a pediatric stem cell transplant and cellular therapy trial evaluating a family health communication…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: A Prediction Model in Pregnant Women With Aplastic Anemia
This ClinicalTrials.gov entry describes a prospective study evaluating a prediction model for outcomes in pregnant women with aplastic anemi…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: ATGAM General Investigation
Pfizer's ATGAM anti-thymocyte globulin trial for aplastic anemia is currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: Umbilical Cord Blood Transplantation From Unrelated Donors
This is an ongoing clinical trial evaluating umbilical cord blood transplantation from unrelated donors for hematologic diseases. The study …
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)
The document announces a new clinical trial called HALO-SCT, assessing high-altitude observation in stem cell transplantation. It is current…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies [EARLY_Phase 1]
An early-phase trial evaluating Darzalex Faspro (daratumumab and hyaluronidase-fihj) given before desensitization and allogeneic stem cell t…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Long Term Follow-up Observational Study After Clinical Trials of AMG531 (Romiplostim) in Patients With Untreated Aplastic Anemia
A long-term follow-up observational study of Romiplostim (AMG531) in patients with untreated aplastic anemia, building on prior clinical tri…
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: Multi-omics Profiling of Patients With Aplastic Anemia Before and After CD7-CAR-T Therapy
The study profiles multi-omics data from patients with aplastic anemia before and after CD7-CAR-T therapy to understand treatment-related bi…
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: Assesment of Treatment Outcomes of Aquired Aplastic Anemia in Children : A Retrospective and Prospective Cohort
A trial update from Assiut University describing a retrospective and prospective cohort study on treatment outcomes for acquired aplastic an…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia [Phase 1]
Phase 1 study evaluating T cell-depleted allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in patients …
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation [Phase 1, Phase 2]
This document provides an update on a phase 1/2 clinical trial evaluating CD34+ stem cell selection for patients receiving allogeneic stem c…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Umbilical Cord Blood-Supported Haplo-HSCT for Aplastic Anemia Treatment Study [NA]
Recruiting clinical trial assessing umbilical cord blood-supported haploidentical hematopoietic stem cell transplantation for treating aplas…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion [Phase 2]
A Phase 2 clinical trial evaluating allogeneic stem cell transplantation with alpha/beta T cell and CD19+ B cell depletion for malignant and…
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: CD7 CAR T Cells (RD13-02) in the Treatment of Relapsed/Refractory Severe Aplastic Anemia [Phase 1]
A Phase 1 clinical trial evaluating CD7 CAR T cells (RD13-02) for relapsed/refractory severe aplastic anemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Haploidentical HCT for Severe Aplastic Anemia [Phase 2]
This document provides an update on a Phase 2 clinical trial evaluating haploidentical hematopoietic cell transplantation for severe aplasti…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children [Phase 2]
A Phase 2 clinical trial at Johns Hopkins All Children's Hospital is evaluating TCR alpha-beta T-cell-depleted haploidentical hematopoietic …
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure. [Phase 2]
Phase 2 trial evaluating hematopoietic cell transplantation with reduced-intensity conditioning and post-transplant cyclophosphamide for sev…
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Dose-attenuated IST and Hetrombopag in Elderly (≥65 Years) Patients With Severe Aplastic Anemia [Phase 2]
Phase 2 clinical trial evaluating dose-attenuated immunosuppressive therapy combined with Hetrombopag in elderly patients (65+) with severe …
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CLINICAL_TRIALS research · 2025-06-04Clinical Trial Update: Efficacy and Safety of Sirolimus With or Without Cyclosporin A in Chinese Patients With Aplastic Anemia Refractory/Intolerant to Cyclosporin A [Phase 2]
Phase 2 clinical trial in Chinese patients with aplastic anemia refractory or intolerant to cyclosporin A assessing the efficacy and safety …