Apical Periodontitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits [NA]
A clinical trial evaluating pain and MMP-9 expression after root canal instrumentation of necrotic pulps with apical periodontitis, comparin…
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis [NA]
A clinical trial comparing Sonic irrigation with Passive Ultrasonic Irrigation for Chronic Apical Periodontitis is currently recruiting at N…
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Effect of Different Root Canal Sealers on Oxidative Stress Markers [NA]
A clinical trial is evaluating whether different root canal sealers influence oxidative stress markers in people with chronic apical periodo…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) [NA]
A clinical trial evaluating chitosan irrigation in premolar root canal therapy is currently recruiting patients with apical periodontitis, d…
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CLINICAL_TRIALS research · 2025-05-11Clinical Trial Update: Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal [NA]
This ClinicalTrials.gov entry outlines an ongoing clinical investigation from the National and Kapodistrian University of Athens evaluating …
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CLINICAL_TRIALS research · 2025-04-17Clinical Trial Update: Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing [NA]
A completed study evaluating photodynamic therapy as an adjunct to root canal treatment in patients with type 2 diabetes, including microbio…
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CLINICAL_TRIALS research · 2025-03-05Clinical Trial Update: Effect of Different Sealers and Activation Methods on Pain [Phase 4]
This clinical trial update describes a Phase 4 study evaluating how different sealer types and activation methods affect pain in chronic api…
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis [Phase 2, Phase 3]
A Phase 2/3 trial is comparing calcium hydroxide and triple antibiotic paste as intra-canal medicaments for teeth with single roots and apic…
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CLINICAL_TRIALS research · 2025-01-08Clinical Trial Update: The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study [Phase 1, Phase 2]
This clinical trial update describes a randomized controlled study evaluating human umbilical cord mesenchymal stem cells and exosomes for h…
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: One Vs Two Visits Root Canal Treatments in Infected Teeth [NA]
A Malmö University trial compares one-visit versus two-visit root canal treatment in teeth with apical periodontitis and dental pulp necrosi…
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CLINICAL_TRIALS research · 2024-11-22Clinical Trial Update: Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis
A clinical trial evaluating the accuracy of point-of-care testing versus ELISA by detecting human IL-6 in teeth affected by apical periodont…
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CLINICAL_TRIALS research · 2024-10-17Clinical Trial Update: Comparative Evaluation of Antimicrobial Efficacy, Clinical and Radiographic Success of Calcium Hydroxide, Chlorhexidine, and Modified Triple Antibiotic Paste in Different Combination Forms As Intracanal Medicaments Against Enterococcus Faecalis in Primary Teeth [NA]
This clinical trial protocol compares calcium hydroxide, chlorhexidine, and modified triple antibiotic paste as intracanal medicaments for E…
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CLINICAL_TRIALS research · 2024-08-29Clinical Trial Update: Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery [NA]
A clinical trial is investigating the effect of photobiomodulation on pain and healing after endodontic microsurgery in patients with apical…
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CLINICAL_TRIALS research · 2024-08-22Clinical Trial Update: Effectiveness of Asiaticoside as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis [Phase 2, Phase 3]
A Phase 2/3 clinical trial is evaluating asiaticoside as an intracanal medication for teeth with apical periodontitis and is currently recru…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence
This clinical trial is evaluating an AI-based method to detect periapical lesions on dental panoramic radiographs. Sponsored by Centre Hospi…
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CLINICAL_TRIALS research · 2024-07-03Clinical Trial Update: Effectiveness of Glycyrrhizin as Intracanal Medication in Root Canal Disinfection and Inflammatory Cytokines [Phase 2, Phase 3]
Mansoura University is conducting a Phase 2/Phase 3 clinical trial to evaluate glycyrrhizin as an intracanal medicament for root canal disin…
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CLINICAL_TRIALS research · 2024-07-01Clinical Trial Update: Revitalization of Traumatized Immature Permanent Teeth
A clinical trial from Universitaire Ziekenhuizen KU Leuven is recruiting to study revitalization of traumatized immature permanent teeth in …
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CLINICAL_TRIALS research · 2024-06-25Clinical Trial Update: No Code Artificial Intelligence to Detect Radiographic Features Associated With Unsatisfactory Endodontic Treatment [NA]
Clinical trial update on a No Code AI tool intended to detect radiographic features associated with unsatisfactory endodontic treatment; the…
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CLINICAL_TRIALS research · 2024-06-20Clinical Trial Update: Investigate"Clinically" the Effectiveness of Boswellia Based Intracanal Medication Compared to Calcium Hydroxide Ca(OH)2 and Ledermix on the Levels of Bacteria and Inflammatory Cytokines in Root Canals and Periradicular Tissues of Teeth With Apical Periodontitis [Phase 2, Phase 3]
An ongoing Phase 2/3 clinical trial at Mansoura University evaluates the effectiveness of a boswellia-based intracanal medicament compared w…
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CLINICAL_TRIALS research · 2024-06-06Clinical Trial Update: Effects of RCT on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in CKD Patients With AP [NA]
This clinical trial update describes a randomized controlled trial evaluating periapical healing, inflammatory markers, and kidney function …
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CLINICAL_TRIALS research · 2024-05-29Clinical Trial Update: Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study [NA]
A prospective interventional study evaluating whether endodontic treatment affects inflammatory markers, rheumatoid arthritis disease activi…
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CLINICAL_TRIALS research · 2024-05-02Clinical Trial Update: The Effect of Photobiomodulation Using Low-Level Diode Laser Therapy on Postoperative Pain in Symptomatic Lower Molar Teeth With Irreversible Pulpitis and Apical Periodontitis; a Randomized Controlled Clinical Trial [NA]
A randomized controlled trial registered on ClinicalTrials.gov is evaluating photobiomodulation using low-level diode laser therapy to reduc…
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CLINICAL_TRIALS research · 2020-09-16Clinical Trial Update: Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis [Phase 2, Phase 3]
Phase 2/3 trial evaluating allogeneic mesenchymal stromal cell transplantation for pulp necrosis and chronic apical periodontitis has comple…
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CLINICAL_TRIALS research · 2018-07-06Clinical Trial Update: FE in Anterior Teeth [NA]
Clinical trial update on FE in anterior teeth with postoperative pain and apical periodontitis; trial status is currently unknown.
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CLINICAL_TRIALS research · 2018-04-10Clinical Trial Update: Influence of Temporary Filling Material Composition on the Success Rate of Endodontic Treatments [NA]
A clinical trial evaluating whether different temporary filling material compositions influence the success rate of endodontic treatments.