Alpha-1 Antitrypsin Deficiency
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-03-13Clinical Trial Update: A Study to Assess Safety and PK of Liquid Alpha₁-Proteinase Inhibitor (Human) in Treating Alpha₁-Antitrypsin Deficiency [Phase 2, Phase 3]
This clinical trial update reports safety and pharmacokinetic results from a Phase 2/3 study of liquid human alpha-1 proteinase inhibitor in…
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CLINICAL_TRIALS trial_result · 2016-12-15Clinical Trial Update: Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency [Phase 1]
Phase 1 clinical trial results posted for an experimental gene transfer procedure aimed at treating Alpha-1 antitrypsin deficiency.
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CLINICAL_TRIALS trial_result · 2016-07-12Clinical Trial Update: Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency. [Phase 4]
This is a Phase 4 extension study of intravenous Zemaira in subjects with emphysema due to alpha-1 antitrypsin deficiency; results from the …
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CLINICAL_TRIALS trial_result · 2016-03-25Clinical Trial Update: Alpha1-antitrypsin Deficiency Registry
A completed NHLBI-sponsored clinical trial registry update for Alpha-1 antitrypsin deficiency and related lung diseases such as emphysema an…
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CLINICAL_TRIALS research · 2016-01-12Clinical Trial Update: Genomic Research in Alpha-1 Antitrypsin Deficiency
The update summarizes the completion of a genomic research study in Alpha-1 Antitrypsin Deficiency (AATD).
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CLINICAL_TRIALS research · 2015-12-07Clinical Trial Update: Prevalence of Alpha-1 Antitrypsin Dysfunction in Pulmonary Emphysema [NA]
A completed clinical trial from Hospices Civils de Lyon evaluating the prevalence of Alpha-1 Antitrypsin deficiency in patients with pulmona…
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CLINICAL_TRIALS trial_result · 2015-01-19Clinical Trial Update: Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency [Phase 4]
Phase 4 clinical trial update reporting Zemaira (alpha-1 proteinase inhibitor) results in subjects with emphysema due to alpha-1 antitrypsin…
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CLINICAL_TRIALS trial_result · 2014-09-09Clinical Trial Update: Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults [Phase 3]
Phase 3 trial comparing pharmacokinetics, safety, and tolerability of Alpha-1 MP versus Prolastin in adults with Alpha-1 antitrypsin deficie…
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CLINICAL_TRIALS trial_result · 2014-08-21Clinical Trial Update: Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE) [Phase 2]
EXACTLE is a Phase 2 trial evaluating Alpha-1 antitrypsin therapy for emphysema in patients with Alpha-1 antitrypsin deficiency. Results wer…
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CLINICAL_TRIALS trial_result · 2014-08-19Clinical Trial Update: The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency [Phase 3]
Phase 3 trial evaluating the safety and tolerability of Alpha-1 Modified Process (MP) in individuals with Alpha-1-antitrypsin deficiency; re…
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CLINICAL_TRIALS trial_result · 2014-05-29Clinical Trial Update: GLASSIA Infusion Rate Study [Phase 4]
Phase 4 trial update on GLASSIA infusion rate study; completed with results posted in 2014.
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CLINICAL_TRIALS trial_result · 2014-01-03Clinical Trial Update: 4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency? [Phase 2]
This update notes the Phase 2 trial of 4-phenylbutyrate to raise alpha-1 antitrypsin levels in individuals with alpha-1 antitrypsin deficien…
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CLINICAL_TRIALS trial_result · 2013-12-17Clinical Trial Update: Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients [NA]
A completed clinical trial comparing the effects of exercise training in chronic obstructive pulmonary disease patients versus those with al…
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CLINICAL_TRIALS trial_result · 2013-05-20Clinical Trial Update: Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency [Phase 2]
Phase 2 trial evaluating safety and pharmacokinetics of Alpha-1 Proteinase Inhibitor in individuals with Alpha-1 antitrypsin deficiency comp…
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CLINICAL_TRIALS trial_result · 2012-09-14Clinical Trial Update: Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency [Phase 2]
Phase 2 clinical trial update on rAAV1-CB-hAAT for alpha-1 antitrypsin deficiency has completed with results posted in 2012.
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CLINICAL_TRIALS trial_result · 2012-01-19Clinical Trial Update: Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD)
This completed clinical trial assessed the prevalence of Alpha-1 Antitrypsin Deficiency among individuals with Chronic Obstructive Pulmonary…
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CLINICAL_TRIALS trial_result · 2011-07-20Clinical Trial Update: Pharmacokinetic Study of ARALAST (Human Alpha1- PI) [Phase 1]
Phase 1 pharmacokinetic study of ARALAST (human Alpha1-antitrypsin) in Alpha 1-Antitrypsin Deficiency was completed with results posted in 2…
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CLINICAL_TRIALS trial_result · 2011-01-04Clinical Trial Update: Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor) [Phase 4]
Phase 4 clinical trial update evaluating augmentation therapy with ARALAST Fraction IV-1 in Alpha 1-antitrypsin deficiency; results posted a…
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CLINICAL_TRIALS research · 2010-12-07Clinical Trial Update: Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema
ClinicalTrials.gov update regarding management of patients with Alpha-1 antitrypsin deficiency–associated emphysema; no results or conclusio…
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CLINICAL_TRIALS research · 2008-03-04Clinical Trial Update: Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals
This completed clinical trial characterizes the early pathobiology of lung destruction in individuals with alpha-1 antitrypsin deficiency, c…
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CLINICAL_TRIALS trial_result · 2007-10-17Clinical Trial Update: Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency [Phase 2, Phase 3]
Phase II/III trial of Kamada-API, an alpha-1 proteinase inhibitor, in individuals with Alpha-1 antitrypsin deficiency has completed. The upd…