Alpha-1 Antitrypsin Deficiency
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2024-05-21Clinical Trial Update: Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease [NA]
Clinical trial update describing a study on hyperpolarized 129Xe MRI to image lung function in healthy volunteers and patients with various …
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CLINICAL_TRIALS withdrawal · 2023-05-06Clinical Trial Update: A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-Emphysema [Phase 4]
Phase 4 trial of RYMPHYSIA for A1PI deficiency in adults with COPD-emphysema has been withdrawn.
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CLINICAL_TRIALS trial_result · 2022-08-08Clinical Trial Update: Safety Dose Finding Study of ADVM-043 Gene Therapy to Treat Alpha-1 Antitrypsin (A1AT) Deficiency [Phase 1, Phase 2]
Phase 1/2 safety and dose-finding study of ADVM-043 gene therapy for Alpha-1 Antitrypsin Deficiency has completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-04-14Clinical Trial Update: A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. [Phase 2]
A Phase 2 trial evaluating alvelestat (MPH966) versus placebo in participants with alpha1-antitrypsin-related COPD has completed.
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CLINICAL_TRIALS trial_result · 2022-02-02Clinical Trial Update: Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype [Phase 2]
Phase 2 trial evaluating VX-814 for Alpha 1-Antitrypsin Deficiency (PiZZ genotype) was terminated; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2021-10-14Clinical Trial Update: GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study [Phase 3]
Phase 3 trial update on GLASSIA assessing safety, immunogenicity, and bronchoalveolar lavage in alpha-1 antitrypsin deficiency has completed…
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CLINICAL_TRIALS trial_result · 2021-10-12Clinical Trial Update: Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency [Phase 2]
Phase 2 trial investigating carbamazepine for severe liver disease due to Alpha-1 antitrypsin deficiency was terminated; results posted late…
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CLINICAL_TRIALS trial_result · 2021-05-05Clinical Trial Update: Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency [Phase 1, Phase 2]
Summary of a safety study evaluating an aerosolized recombinant alpha1-antitrypsin in individuals with alpha1-antitrypsin deficiency (Phase …
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CLINICAL_TRIALS trial_result · 2021-05-05Clinical Trial Update: Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency [Phase 1, Phase 2]
A clinical trial evaluating aerosolized recombinant alpha-1 antitrypsin in subjects with alpha-1 antitrypsin deficiency has completed Phase …
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CLINICAL_TRIALS trial_result · 2021-02-18Clinical Trial Update: Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin Deficiency [Phase 1, Phase 2]
A completed Phase 1/2 trial evaluating safety and pharmacokinetics of Alpha-1 MP (modified process human alpha1-proteinase inhibitor) in ind…
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CLINICAL_TRIALS trial_result · 2021-02-17Clinical Trial Update: Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency [Phase 2]
Phase 2 clinical trial update investigating targeting pulmonary perfusion in alpha-1 antitrypsin deficiency with results posted.
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CLINICAL_TRIALS withdrawal · 2020-09-14Clinical Trial Update: ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study [Phase 4]
A Phase 4 clinical trial for ARALAST NP in COPD with Alpha1-antitrypsin deficiency has been withdrawn.
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CLINICAL_TRIALS trial_result · 2020-04-21Clinical Trial Update: Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency [Phase 2]
Phase 2 trial evaluating the efficacy and safety of an inhaled HA solution for hereditary emphysema due to alpha-1 antitrypsin deficiency ha…
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CLINICAL_TRIALS trial_result · 2020-01-18Clinical Trial Update: Phase II, Safety and Efficacy Study of Kamada-alpha-1-antitrypsin (AAT) for Inhalation" [Phase 2]
Phase II trial assessing inhaled Kamada-alpha-1-antitrypsin for Alpha-1 Antitrypsin Deficiency completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-10-08Clinical Trial Update: Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency [Phase 3]
Phase 3 trial update for ARALAST NP and GLASSIA in alpha-1 antitrypsin deficiency (A1PI) has terminated; results posted.
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CLINICAL_TRIALS trial_result · 2019-07-22Clinical Trial Update: Alpha-1 Carrier Genomics Study
A completed clinical trial study on Alpha-1 Antitrypsin Deficiency and Emphysema with results posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-05-08Clinical Trial Update: Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation. [Phase 2]
A Phase 2 clinical trial investigated the effects of a double dose of alpha-1 antitrypsin augmentation therapy on lung inflammation in patie…
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CLINICAL_TRIALS trial_result · 2018-08-03Clinical Trial Update: A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD) [Phase 1]
Phase 1 study evaluating ARC-AAT in healthy volunteers and patients with Alpha-1 Antitrypsin Deficiency (AATD) was terminated; results were …
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CLINICAL_TRIALS trial_result · 2018-07-16Clinical Trial Update: The Impact of Delayed Diagnosis of Alpha-1 Antitrypsin Deficiency
A completed clinical trial update examining the impact of delayed diagnosis of Alpha-1 Antitrypsin Deficiency on patient outcomes. The study…
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CLINICAL_TRIALS trial_result · 2018-07-13Clinical Trial Update: Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability [NA]
Phase 2 trial evaluating ex-vivo lung perfusion and ventilation to assess transplant suitability, sponsored by the University of North Carol…
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CLINICAL_TRIALS trial_result · 2018-04-20Clinical Trial Update: Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability [NA]
This completed clinical trial evaluated ex-vivo perfusion and ventilation of donor lungs recovered from non-heart-beating donors to assess t…
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CLINICAL_TRIALS withdrawal · 2018-04-10Clinical Trial Update: Study Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin Deficiency [Phase 2]
A Phase 2 trial comparing OctaAlpha1 to Glassia for Alpha-1 antitrypsin deficiency has been withdrawn.
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CLINICAL_TRIALS research · 2017-05-31Clinical Trial Update: Liver Disease in Patients With alpha1-antitrypsin Deficiency
This clinical trial update concerns liver disease in patients with alpha-1 antitrypsin deficiency. No status or results are provided in the …
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CLINICAL_TRIALS trial_result · 2017-05-04Clinical Trial Update: Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant [Phase 3]
Phase 3 randomized trial comparing Simulect (basiliximab) plus standard immunosuppression to standard immunosuppression alone for prevention…
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CLINICAL_TRIALS withdrawal · 2017-05-02Clinical Trial Update: Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency [NA]
A ClinicalTrials.gov study on Lung Volume Reduction Coils for emphysema in Alpha-1 antitrypsin deficiency has been withdrawn.