Al Amyloidosis
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CLINICAL_TRIALS trial_result · 2024-08-26Clinical Trial Update: AL Amyloidosis and Anti-CD38-Daratunumab [NA]
Completed clinical trial evaluating daratumumab, an anti-CD38 antibody, for AL amyloidosis.
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CLINICAL_TRIALS trial_result · 2024-03-06Clinical Trial Update: Isatuximab Plus Pomalidomide and Dexamethasone Association for Patients With AL Amyloidosis Not in VGPR or Better After Any Previous Therapy [Phase 2]
Phase 2 trial evaluating Isatuximab plus pomalidomide and dexamethasone for AL amyloidosis patients not achieving VGPR or better after prior…
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CLINICAL_TRIALS trial_result · 2023-11-18Clinical Trial Update: COVID-19 VAX Booster Dosing in Patients With Hematologic Malignancies [Phase 2]
A Phase 2 clinical trial evaluating a COVID-19 vaccine booster dosing in patients with hematologic malignancies has completed enrollment and…
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CLINICAL_TRIALS trial_result · 2022-09-29Clinical Trial Update: Ixazomib In Combination With Cyclophosphamide And Dexamethasone for Newly Diagnosed AL Amyloidosis [Phase 1, Phase 2]
Phase 1/2 trial evaluating ixazomib in combination with cyclophosphamide and dexamethasone for newly diagnosed AL amyloidosis has completed.
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CLINICAL_TRIALS trial_result · 2022-09-21Clinical Trial Update: Ixazomib With Cyclophosphamide and Dexamethasone in Patients With Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis [Phase 1, Phase 2]
Phase 1/2 study of ixazomib with cyclophosphamide and dexamethasone in previously untreated symptomatic multiple myeloma or AL amyloidosis. …
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CLINICAL_TRIALS trial_result · 2021-05-07Clinical Trial Update: Daratumumab for the Treatment of Patients With AL Amyloidosis [Phase 1, Phase 2]
Phase 1/2 trial evaluating daratumumab for AL amyloidosis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-03-04Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Daratumumab in Combination With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared to CyBorD Alone in Newly Diagnosed Systemic Amyloid Light-chain (AL) Amyloidosis [Phase 3]
A Phase 3 trial compared daratumumab added to CyBorD versus CyBorD alone in newly diagnosed systemic AL amyloidosis, with results posted in …
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CLINICAL_TRIALS trial_result · 2020-03-30Clinical Trial Update: Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis [Phase 2]
Phase 2 clinical trial evaluating bendamustine and dexamethasone in relapsed AL amyloidosis completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-12-16Clinical Trial Update: A Phase I/II Trial of Pomalidomide and Dexamethasone in Subjects With Previously-Treated AL Amyloidosis [Phase 1, Phase 2]
Phase I/II trial evaluating pomalidomide plus dexamethasone in previously treated AL amyloidosis completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-05-16Clinical Trial Update: Open-label Extension Study of NEOD001 in Subjects With Light Chain (AL) Amyloidosis [Phase 2]
An open-label extension study for NEOD001 in AL amyloidosis was terminated; results were posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-04-05Clinical Trial Update: The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosis [Phase 2]
Phase 2b study results for NEOD001 in previously treated AL amyloidosis completed; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2018-12-12Clinical Trial Update: Study in Subjects With Light Chain (AL) Amyloidosis [Phase 2]
Phase 2 clinical trial in AL amyloidosis (study terminated; results posted in 2018).
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CLINICAL_TRIALS trial_result · 2018-08-06Clinical Trial Update: Trial of High Dose Melphalan/Stem Cell Transplant With or Without Bortezomib [Phase 3]
Phase 3 trial evaluating high-dose melphalan with or without bortezomib in AL amyloidosis; study terminated with results posted.
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CLINICAL_TRIALS trial_result · 2018-04-25Clinical Trial Update: Immune Mobilization of Autologous Peripheral Blood Stem Cells Using Interleukin-2 and GM-CSF [Phase 1]
Phase 1 study evaluating mobilization of autologous peripheral blood stem cells using interleukin-2 and GM-CSF; the trial has completed.
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CLINICAL_TRIALS trial_result · 2018-03-21Clinical Trial Update: Epigallocatechingallate (EGCG) in Cardiac AL Amyloidosis [Phase 2]
Phase 2 trial evaluating Epigallocatechin gallate (EGCG) for cardiac AL amyloidosis has been terminated.
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CLINICAL_TRIALS trial_result · 2018-03-12Clinical Trial Update: Pomalidomide and Dexamethasone (PDex) in AL Amyloidosis [Phase 2]
Phase 2 trial evaluating pomalidomide with dexamethasone (PDex) for AL amyloidosis has completed.
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CLINICAL_TRIALS trial_result · 2017-04-07Clinical Trial Update: Study of Bortezomib +HSCT in Primary Systemic Amyloidosis (AL) [NA]
This document notes the completion of a clinical trial evaluating the combination of bortezomib with hematopoietic stem cell transplantation…
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CLINICAL_TRIALS trial_result · 2017-03-22Clinical Trial Update: A Pilot Study of Lenalidomide, Melphalan and Dexamethasone in AL Amyloidosis [NA]
A pilot study of lenalidomide, melphalan, and dexamethasone in AL amyloidosis has completed, with results posted in March 2017.
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CLINICAL_TRIALS trial_result · 2017-03-10Clinical Trial Update: A Trial for Systemic Light-chain (AL) Amyloidosis [Phase 3]
A Phase 3 trial for systemic light-chain (AL) amyloidosis has completed, according to ClinicalTrials.gov.
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CLINICAL_TRIALS trial_result · 2017-02-20Clinical Trial Update: Melphalan, Lenalidomide, and Dexamethasone in Treating Patients With Primary Systemic Amyloidosis [Phase 2]
This is a Phase 2 clinical trial update reporting results for melphalan, lenalidomide, and dexamethasone in AL amyloidosis (primary systemic…
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CLINICAL_TRIALS trial_result · 2017-02-20Clinical Trial Update: CC-5013 With or Without Dexamethasone in Treating Patients With Primary Systemic Amyloidosis [Phase 2]
Phase 2 trial evaluating lenalidomide (CC-5013) with or without dexamethasone for AL amyloidosis; results were posted.
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CLINICAL_TRIALS trial_result · 2017-01-27Clinical Trial Update: 2nd Autologous Stem Cell Transplant in Patients With Persistent/Recurrent (AL) Amyloidosis [Phase 2]
Phase 2 trial update evaluating a second autologous stem cell transplant in patients with persistent or recurrent AL amyloidosis, with resul…
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CLINICAL_TRIALS trial_result · 2015-07-24Clinical Trial Update: Allo SCT in Amyloidosis Non-interventional Study
Completed non-interventional study evaluating allogeneic stem cell transplantation in patients with AL amyloidosis.
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CLINICAL_TRIALS trial_result · 2015-03-25Clinical Trial Update: Risk-adapted Therapy for Primary Systemic (AL) Amyloidosis [Phase 2]
Phase 2 trial evaluating risk-adapted therapy for primary systemic AL amyloidosis; the study status is completed.
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CLINICAL_TRIALS trial_result · 2015-03-06Clinical Trial Update: S9628 Dexamethasone Plus Interferon Alfa in Treating Patients With Primary Systemic Amyloidosis [Phase 2]
Phase 2 SWOG trial evaluating dexamethasone plus interferon alfa in AL amyloidosis has completed enrollment. The update does not provide det…