Al Amyloidosis
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CLINICAL_TRIALS trial_result · 2026-06-02Clinical Trial Update: Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosis [Phase 3]
Phase 3 trial evaluating [18F]Florbetaben PET for diagnosing Cardiac AL Amyloidosis has been completed.
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Novel Imaging Tools in Newly-diagnosed Patients With Cardiac AL Amyloidosis [NA]
A completed study evaluating novel imaging tools in newly diagnosed cardiac AL amyloidosis patients.
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) Amyloidosis [Phase 2]
A Phase 2 clinical trial evaluating belantamab mafodotin in combination with cyclophosphamide, bortezomib, and dexamethasone for newly diagn…
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES) [Phase 3]
Phase 3 CARES trial evaluating CAEL-101 for Mayo Stage IIIb AL amyloidosis is ongoing and currently not recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis
Completed clinical trial update describing approaches to monitoring early disease progression in hereditary transthyretin amyloidosis. The s…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis [Phase 1, Phase 2]
A Phase 1/2a clinical trial is investigating belantamab mafodotin for relapsed or refractory AL amyloidosis; the study is currently recruiti…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: Safety and Efficacy of GPRC5D CAR-T Cell Therapy in Relapsed/Refractory Plasma Cell Disorders [EARLY_Phase 1]
An early-phase Phase 1 trial evaluating a GPRC5D-targeted CAR-T cell therapy for relapsed/refractory plasma cell disorders, with the study n…
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CLINICAL_TRIALS trial_result · 2026-01-13Clinical Trial Update: Sonrotoclax Plus Dexamethasone With or Without Daratumumab Regimen in Patients With t(11;14) Primary AL Amyloidosis [Phase 2]
Phase 2 clinical trial evaluating sonrotoclax plus dexamethasone with or without daratumumab in patients with t(11;14) positive primary AL a…
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CLINICAL_TRIALS trial_result · 2025-12-04Clinical Trial Update: Ixazomib Maintenance Study in Patients With AL Amyloidosis [Phase 2]
A Phase 2 study evaluating ixazomib as maintenance therapy for AL amyloidosis, with the trial currently active and not recruiting.
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: A Study of Belantamab Mafodotin in Patients With Relapsed or Refractory AL Amyloidosis [Phase 2]
Phase 2 study evaluating belantamab mafodotin in relapsed or refractory AL amyloidosis has completed. The trial was conducted under the Stic…
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CLINICAL_TRIALS trial_result · 2025-05-01Clinical Trial Update: Nutritional Counseling in Systemic Immunoglobulin Light-chain Amyloidosis [NA]
A completed clinical trial evaluating nutritional counseling in patients with systemic AL amyloidosis.
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: A Study to Evaluate the Safety and Tolerability of CAEL-101 in Patients With AL Amyloidosis [Phase 2]
A Phase 2 study evaluating CAEL-101 (birtamimab) for safety and tolerability in patients with AL amyloidosis has completed. Results were pos…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: Daratumumab and Pomalidomide in Previously Treated Patients With AL Amyloidosis [Phase 2]
The Phase 2 trial evaluating daratumumab plus pomalidomide in previously treated AL amyloidosis was terminated.
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CLINICAL_TRIALS trial_result · 2025-02-07Clinical Trial Update: Study of Chimeric Fibril-Reactive Monoclonal Antibody 11-1F4 in Patients With AL Amyloidosis [Phase 1]
This entry reports the completion of a Phase 1 clinical trial evaluating a chimeric fibril-reactive monoclonal antibody designated 11-1F4 in…
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CLINICAL_TRIALS trial_result · 2024-11-12Clinical Trial Update: Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT [EARLY_Phase 1]
An early-phase trial evaluating molecular imaging with PET/CT to understand the mechanism of cardiotoxicity in patients with light-chain (AL…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis [Phase 1, Phase 2]
A Phase 1/2 study of ZN-d5 for relapsed or refractory AL amyloidosis has completed.
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CLINICAL_TRIALS trial_result · 2024-08-26Clinical Trial Update: AL Amyloidosis and Anti-CD38-Daratunumab [NA]
Completed clinical trial evaluating daratumumab, an anti-CD38 antibody, for AL amyloidosis.
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CLINICAL_TRIALS trial_result · 2024-03-06Clinical Trial Update: Isatuximab Plus Pomalidomide and Dexamethasone Association for Patients With AL Amyloidosis Not in VGPR or Better After Any Previous Therapy [Phase 2]
Phase 2 trial evaluating Isatuximab plus pomalidomide and dexamethasone for AL amyloidosis patients not achieving VGPR or better after prior…
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CLINICAL_TRIALS trial_result · 2023-11-18Clinical Trial Update: COVID-19 VAX Booster Dosing in Patients With Hematologic Malignancies [Phase 2]
A Phase 2 clinical trial evaluating a COVID-19 vaccine booster dosing in patients with hematologic malignancies has completed enrollment and…
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CLINICAL_TRIALS trial_result · 2022-09-29Clinical Trial Update: Ixazomib In Combination With Cyclophosphamide And Dexamethasone for Newly Diagnosed AL Amyloidosis [Phase 1, Phase 2]
Phase 1/2 trial evaluating ixazomib in combination with cyclophosphamide and dexamethasone for newly diagnosed AL amyloidosis has completed.
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CLINICAL_TRIALS trial_result · 2022-09-21Clinical Trial Update: Ixazomib With Cyclophosphamide and Dexamethasone in Patients With Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis [Phase 1, Phase 2]
Phase 1/2 study of ixazomib with cyclophosphamide and dexamethasone in previously untreated symptomatic multiple myeloma or AL amyloidosis. …
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CLINICAL_TRIALS trial_result · 2021-05-07Clinical Trial Update: Daratumumab for the Treatment of Patients With AL Amyloidosis [Phase 1, Phase 2]
Phase 1/2 trial evaluating daratumumab for AL amyloidosis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-03-04Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Daratumumab in Combination With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared to CyBorD Alone in Newly Diagnosed Systemic Amyloid Light-chain (AL) Amyloidosis [Phase 3]
A Phase 3 trial compared daratumumab added to CyBorD versus CyBorD alone in newly diagnosed systemic AL amyloidosis, with results posted in …
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CLINICAL_TRIALS trial_result · 2020-03-30Clinical Trial Update: Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis [Phase 2]
Phase 2 clinical trial evaluating bendamustine and dexamethasone in relapsed AL amyloidosis completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-12-16Clinical Trial Update: A Phase I/II Trial of Pomalidomide and Dexamethasone in Subjects With Previously-Treated AL Amyloidosis [Phase 1, Phase 2]
Phase I/II trial evaluating pomalidomide plus dexamethasone in previously treated AL amyloidosis completed with posted results.