Aggressive B-cell Non-hodgkin Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma [Phase 3]
This Phase 3 clinical trial (NCT06230224) compares odronextamab to standard of care in adults with previously treated aggressive B-cell non-…
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CLINICAL_TRIALS trial_result · 2026-04-01Clinical Trial Update: Pembrolizumab and Tazemetostat to Overcome Immune Tolerance Following ASCT or CAR T-cell Therapy in Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma [Phase 2]
Phase 2 clinical trial evaluating pembrolizumab and tazemetostat to overcome immune tolerance after ASCT or CAR-T therapy in patients with a…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma [Phase 2]
Phase 2 clinical trial update evaluating CRS profile optimization for glofitamab combined with gemcitabine and oxaliplatin in relapsed/refra…
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CLINICAL_TRIALS trial_result · 2026-03-20Clinical Trial Update: ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma [Phase 1, Phase 2]
A Phase 1/2 study evaluating ALX148 in combination with Rituximab and Lenalidomide for various B-cell non-Hodgkin lymphomas, with the trial …
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Clinical Study of SYS6055 Injection in Participants With Relapsed/Refractory Aggressive B-Cell Lymphoma [Phase 1, Phase 2]
Phase 1/2 study evaluating SYS6055 Injection in participants with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma. The trial is c…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma [Phase 3]
A Phase 3 clinical trial comparing Mosunetuzumab in combination with Polatuzumab Vedotin against Rituximab in combination with Gemcitabine p…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: A Phase I/II Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of the EMB-07 Combination Therapy in Patients With Aggressive B-Cell Non-Hodgkin Lymphoma [Phase 1, Phase 2]
Phase I/II clinical trial evaluating EMB-07 in combination therapy for aggressive B-cell non-Hodgkin lymphoma; currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Nivolumab With DA-REPOCH Chemotherapy Regimen in Treating Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma [Phase 2]
Ongoing Phase 2 trial evaluating nivolumab in combination with DA-REPOCH chemotherapy for aggressive B-cell non-Hodgkin lymphomas, including…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Golcadomide and Rituximab as Bridging Therapy for Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma Before CAR T-cell Therapy [Phase 2]
A Phase 2 clinical trial investigates golcadomide in combination with rituximab as bridging therapy for relapsed or refractory aggressive B-…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: A Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic Malignancies [Phase 1]
A Phase 1 clinical trial evaluates PRT2527 as a standalone therapy and in combination with zanubrutinib or venetoclax for relapsed/refractor…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: High Dose Therapy and Autologous Stem Cell Transplantation Followed by Infusion of Chimeric Antigen Receptor (CAR) Modified T-Cells Directed Against CD19+ B-Cells for Relapsed and Refractory Aggressive B Cell Non-Hodgkin Lymphoma [Phase 1]
A Phase 1 clinical trial is evaluating high-dose therapy with autologous stem cell transplant followed by infusion of CD19-directed CAR-T ce…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: DNA Sequencing-Based Monitoring of Minimal Residual Disease to Predict Clinical Relapse in Aggressive B-cell Non-Hodgkin Lymphomas
This clinical trial update describes a study using DNA sequencing to monitor minimal residual disease in aggressive B-cell non-Hodgkin lymph…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: MEN1703 (SEL24) to Treat Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma (JASPIS-01) [Phase 2]
A Phase 2 clinical trial (JASPIS-01) evaluating MEN1703 (SEL24) for relapsed or refractory aggressive B-cell non-Hodgkin lymphoma is current…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Integrated Radiotherapy-optimized ASCT Sequential CAR-T Therapy for Patients With Relapsed and Refractory B-NHL [NA]
A clinical trial is recruiting for an integrated radiotherapy-optimized ASCT sequential CAR-T therapy for relapsed or refractory aggressive …
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: The Application of CAR-T Cell Therapy in Relapsed and Refractory Malignant Hematologic Tumors [Phase 1, Phase 2]
Ongoing Phase 1/Phase 2 trials are evaluating CAR-T cell therapy for relapsed or refractory malignant hematologic tumors, including aggressi…
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CLINICAL_TRIALS trial_result · 2024-12-27Clinical Trial Update: Trial to Determine the Efficacy and Safety of JCAR017 in Adult Participants With Aggressive B-Cell Non-Hodgkin Lymphoma [Phase 2]
A Phase 2 trial sponsored by Celgene evaluating lisocabtagene maraleucel (JCAR017) in adults with aggressive B-cell non-Hodgkin lymphoma has…
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CLINICAL_TRIALS trial_result · 2022-06-08Clinical Trial Update: A comparatiVe Study on Efficacy and Safety of Lipegfilgrastim in Comparison to Pegfilgrastim in Elderly Patients With Aggressive B Cell Non-HOdgkin Lymphomas at hIgh Risk for R-CHOP-21-inDuced Neutropenia [Phase 3]
A Phase 3 trial comparing lipegfilgrastim to pegfilgrastim in elderly patients with aggressive B-cell non-Hodgkin lymphoma at high risk of R…
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CLINICAL_TRIALS trial_result · 2021-07-07Clinical Trial Update: Pegfilgrastim and Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Aggressive B-Cell Non-Hodgkin Lymphoma [Phase 2]
Phase 2 trial update evaluating pegfilgrastim with combination chemotherapy, with or without rituximab, in older patients with aggressive B-…
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CLINICAL_TRIALS trial_result · 2020-06-02Clinical Trial Update: Study of Rituximab-HCVAD Alternating With Rituximab-Methotrexate-Cytarabine Versus Standard Rituximab-CHOP Every 21 Days for Patients With Newly Diagnosed High Risk Aggressive B-Cell Non-Hodgkin's Lymphomas in Patients 60 Years Old or Younger [Phase 2]
Phase 2 trial comparing Rituximab-HCVAD alternating with Rituximab-Methotrexate-Cytarabine vs Rituximab-CHOP in newly diagnosed high-risk ag…
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CLINICAL_TRIALS research · 2014-07-08Clinical Trial Update: Thiotepa, Busulfan and Fludarabin for pt With Refractory/Early Relapsed Aggressive B-cell Non Hodgkin Lymphomas [Phase 2]
This clinical trial update describes a Phase 2 study evaluating thiotepa, busulfan, and fludarabine in patients with refractory or early-rel…
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CLINICAL_TRIALS trial_result · 2012-04-12Clinical Trial Update: A Pilot Study of Standard-Dose Rituximab, Ifosfamide, Carboplatin and Etoposide (RICE) Plus Bortezomib (Velcade) in a Dose-Escalating Fashion for Patients With Relapsed or Primary Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma Who Are Candidates for Autologous Stem Cell Transplant [EARLY_Phase 1]
An early-phase (Phase 1) pilot study evaluating dose-escalating RICE chemotherapy plus bortezomib for relapsed or primary refractory aggress…