Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-10-24Clinical Trial Update: FT538 in Combination With Daratumumab in AML Acute Myeloid Leukemia [Phase 1]
This Phase 1 trial evaluated FT538 in combination with daratumumab in acute myeloid leukemia, including monocytic leukemia, and has complete…
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CLINICAL_TRIALS trial_result · 2024-10-23Clinical Trial Update: A Study to Evaluate Escalating Doses of ASP1235 (AGS62P1) Given as Monotherapy in Subjects With Acute Myeloid Leukemia (AML) [Phase 1]
A Phase 1 trial evaluating escalating doses of ASP1235 (AGS62P1) as monotherapy in subjects with acute myeloid leukemia has been terminated.
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CLINICAL_TRIALS trial_result · 2024-10-22Clinical Trial Update: Testing Nivolumab in Combination With Decitabine and Venetoclax in Patients With Newly Diagnosed TP53 Gene Mutated Acute Myeloid Leukemia [Phase 1]
Phase 1 trial evaluating nivolumab in combination with decitabine and venetoclax for newly diagnosed TP53-mutated acute myeloid leukemia; st…
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CLINICAL_TRIALS research · 2024-10-22Clinical Trial Update: Molecular Subtype Combined with Early Minimal Residual Disease to Optimize the Treatment of Newly Diagnosed Acute Myeloid Leukemia [Phase 2]
Phase 2 clinical trial investigating how AML molecular subtype and early measurable residual disease can guide initial treatment choices.
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CLINICAL_TRIALS research · 2024-10-22Clinical Trial Update: Selinexor in Combination With HAD or CAG Rregimens in Relapsed or Refractory Acute Myeloid Leukemia [Phase 3]
A Phase 3 clinical trial evaluating selinexor in combination with HAD or CAG regimens for relapsed or refractory acute myeloid leukemia is c…
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CLINICAL_TRIALS trial_result · 2024-10-21Clinical Trial Update: Cytomegalovirus (CMV) Vaccine in Donors and Recipients Undergoing Allogeneic Hematopoietic Cell Transplant (HCT) [Phase 2]
Phase 2 trial of a cytomegalovirus vaccine for donors and recipients undergoing allogeneic hematopoietic cell transplantation has completed,…
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CLINICAL_TRIALS trial_result · 2024-10-17Clinical Trial Update: CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML [Phase 2]
Phase 2 clinical trial evaluating CD34-selected allogeneic hematopoietic stem cell transplantation with myeloablative conditioning plus CD8+…
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CLINICAL_TRIALS trial_result · 2024-10-16Clinical Trial Update: A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia. [Phase 1, Phase 2]
Astellas reports results from a Phase 1/2 study of ASP2215 (gilteritinib) in combination with induction and consolidation chemotherapy for n…
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CLINICAL_TRIALS trial_result · 2024-10-16Clinical Trial Update: Study of a New Intravenous Drug, Called S65487, in Patients With Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma or Chronic Lymphocytic Leukemia [Phase 1]
Phase 1 study of the intravenous agent S65487 in relapsed or refractory hematologic cancers (acute myeloid leukemia, non-Hodgkin lymphoma, m…
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CLINICAL_TRIALS research · 2024-10-16Clinical Trial Update: CD155 Expression in Acute Myeloid Leukemia
This entry reports a completed clinical trial investigating CD155 expression in acute myeloid leukemia.
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: A Phase I Single-arm Clinical Study of Donor NK Cells Infusion Combined with Low-dose Interleukin-2 in the Treatment of Acute Myeloid Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation. [Phase 1]
A Phase I, single-arm study evaluating donor NK cell infusion combined with low-dose interleukin-2 for relapse of acute myeloid leukemia aft…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: EX02 CAR-T Cells for Relapsed and Refractory Acute Myeloid Leukemia [EARLY_Phase 1]
An early-phase 1 clinical trial evaluating EX02 CAR-T cells for relapsed and refractory acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: A Phase Ib Study of APG-115 Single Agent or in Combination With Azacitidine or Cytarabine in Patients With AML and MDS. [Phase 1]
Phase Ib clinical trial of APG-115 as a single agent or in combination with azacitidine or cytarabine for acute myeloid leukemia or myelodys…
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CLINICAL_TRIALS trial_result · 2024-10-15Clinical Trial Update: Post-transplantation Benadamustine and Cyclophosphamide in Patients With Refractory Myeloid Malignancies [Phase 2]
Phase 2 trial evaluating post-transplantation bendamustine and cyclophosphamide in refractory myeloid malignancies has completed.
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FDA approval · 2024-10-15FDA Approved: AZACITIDINE — Original Application (Camber Pharmaceuticals, Inc.)
FDA approved Camber Pharmaceuticals' generic azacitidine (AZACITIDINE) under an original application. The drug is indicated for myelodysplas…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Safety, Tolerability, PK, PD, and Efficacy of AMG 427 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
This Phase 1 study of AMG 427 in relapsed/refractory acute myeloid leukemia assessed safety, tolerability, PK/PD, and preliminary efficacy; …
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CLINICAL_TRIALS research · 2024-10-10Clinical Trial Update: Efficacy of Venetoclax Combined with Intensive Chemotherapy in Different Subgroups of AML [Phase 2]
A Phase 2 trial assessing venetoclax with intensive chemotherapy in different subgroups of acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Cardiovascular Function in Acute Leukemia
A completed clinical trial update evaluating cardiovascular function and potential cardiotoxicity in patients with acute leukemia.
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: Lintuzumab-Ac225 in Combination with Cladribine + Cytarabine + Filgastrim + Mitoxantrone (CLAG-M) for Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
Phase 1 clinical trial evaluating lintuzumab-ac225 in combination with CLAG-M for relapsed/refractory acute myeloid leukemia has completed.
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CLINICAL_TRIALS research · 2024-10-04Clinical Trial Update: Integrative "Omics" Approaches for Leukemia Target Identification and Matched Therapeutic Intervention [NA]
The study uses integrative 'omics' approaches to identify leukemia targets and matched therapeutic interventions and is currently recruiting…
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CLINICAL_TRIALS research · 2024-10-03Clinical Trial Update: Venetoclax + Decitabine vs. "7+3" Induction Chemotherapy in Young AML [Phase 3]
This Phase 3 trial compares venetoclax plus decitabine with standard 7+3 induction chemotherapy in young adults with acute myeloid leukemia.
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CLINICAL_TRIALS trial_result · 2024-10-02Clinical Trial Update: A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy [Phase 3]
A Phase 3 clinical trial evaluating the combination of IDH1 inhibitor ivosidenib or IDH2 inhibitor enasidenib with induction and consolidati…
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: Fludarabine and Cytarabine Versus High-dose Cytarabine for CBF-AML [Phase 4]
Phase 4 trial comparing fludarabine plus cytarabine versus high-dose cytarabine in core-binding factor acute myeloid leukemia has completed.
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CLINICAL_TRIALS withdrawal · 2024-10-01Clinical Trial Update: Induction Therapy for Patients With FLT3 Mutated Acute Myeloid Leukemia [Phase 1, Phase 2]
A phase 1/2 clinical trial of induction therapy for FLT3-mutated acute myeloid leukemia has been withdrawn.
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: VA as Maintenance Therapy Post Allo-HSCT in MDS and AML [Phase 2]
A Phase 2 trial evaluating VA as maintenance therapy after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome a…