Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-12-09Clinical Trial Update: Study of Single and Multiple Ascending Doses of ZE46-0134 in Healthy Volunteers [Phase 1]
Phase 1 dose-escalation study of ZE46-0134 in healthy volunteers has completed, with acute myeloid leukemia listed as the related condition.
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: PTX3-targeted Antifungal Prophylaxis [NA]
A clinical trial is recruiting to evaluate PTX3-targeted antifungal prophylaxis for preventing candidiasis and other fungal infections, incl…
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: Quality of Life Model for Older Patients With AML
Clinical trial update describing development of a quality-of-life model for older adults with acute myeloid leukemia, sponsored by H. Lee Mo…
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CLINICAL_TRIALS trial_result · 2025-12-08Clinical Trial Update: Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML) [Phase 1, Phase 2]
This clinical trial update describes pharmacokinetics, safety, and preliminary efficacy of the ASTX727 and venetoclax combination in patient…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: An Efficacy and Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy in Chinese Participants With Acute Myeloid Leukemia in Complete Remission [Phase 2]
A Phase 2 trial evaluating oral azacitidine (CC-486) as maintenance therapy for Chinese participants with acute myeloid leukemia in complete…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Automated vs Manual Flow-cytometry Gating for Measurable Residual Disease in Acute Myeloid Leukaemia (DUALFLOW)
Clinical trial evaluating automated versus manual flow-cytometry gating for measurable residual disease in adults with acute myeloid leukemi…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell Transplant
An ongoing clinical trial investigating muscle dysfunction in patients with hematologic diseases referred for stem cell transplantation.
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: A Long-term Follow-up Study of Patients With ARD103 CAR-T Cell Therapies
This document reports a long-term follow-up study of patients treated with ARD103 CAR-T cell therapy for acute myeloid leukemia (relapsed or…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Study of Families With an Hemopathies Predisposition Related to the DDX41 Gene. [NA]
A clinical trial update describing families with a hematopathy predisposition related to the DDX41 gene mutation. The study is currently rec…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX
A recruiting clinical trial evaluating a combined sensitising and hypomethylating therapy for acute myeloid leukemia using patient-derived x…
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Efficacy of Venetoclax Based Regimen in Prevention Relapse of Consecutive MRD Positive AML Patients [Phase 2]
Phase 2 trial of a venetoclax-based regimen to prevent relapse in MRD-positive acute myeloid leukemia was terminated.
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: The Oronasal Microbiota in Pediatric Oncology Patients
A completed clinical trial evaluating the oronasal microbiota in pediatric oncology patients, including those with acute myeloid leukemia an…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Vyxeos Plus Gilteritinib in Relapsed or Refractory, FLT3-Mutated AML [Phase 1]
This update describes an ongoing Phase 1 study evaluating Vyxeos plus gilteritinib for relapsed or refractory FLT3-mutated acute myeloid leu…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Study Investigating the Safety of CD19 CAR-T Cells in Relapsed/Refractory AML Expressing CD19 [Phase 1]
A Phase 1 clinical trial is investigating the safety of CD19 CAR-T cells in patients with relapsed or refractory acute myeloid leukemia that…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors [Phase 2]
Phase 2 study evaluating exercise training with nicotinamide riboside (NR) supplementation to improve fitness in adolescent/young adult hema…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Sorafenib Combined With Venetoclax as Pre-emptive Therapy Strategy for MRD+ AML: a Prospective, Single-arm, Multicenter Clinical Study [Phase 2, Phase 3]
A prospective single-arm multicenter Phase 2/3 trial evaluating the combination of sorafenib and venetoclax as pre-emptive therapy for measu…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Expanded Natural Killer Cells Following Haploidentical HSCT for AML/MDS [Phase 1, Phase 2]
Clinical trial investigating expanded natural killer cells after haploidentical hematopoietic stem cell transplantation for acute myeloid le…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission [Phase 2]
A Phase 2 trial evaluating two dose levels of quizartinib as maintenance therapy in FLT3-ITD-positive acute myeloid leukemia patients in com…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Clinical Study of LILRA6 CAR-T for the Treatment of R/R Acute Myeloid Leukemia [Phase 1]
A Phase 1 study evaluating LILRA6 CAR-T therapy for relapsed or refractory acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics [Phase 1]
Phase 1 study assessing how moderate renal impairment and race/ethnicity influence treosulfan pharmacokinetics in Acute Myeloid Leukemia and…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML [Phase 1]
A Phase I study of the selective nuclear export inhibitor KPT-330 (selinexor) in children with relapsed or refractory acute lymphoblastic le…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: A Study of (Interleukin-12) IL-12 in Patients With Acute Myelogenous Leukemia (AML) [Phase 1]
This clinical trial update describes a Phase 1 study of Interleukin-12 in patients with Acute Myeloid Leukemia, which is currently active bu…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Feasibility and Safety of Donor-derived NK-cell Infusions for Leukemia Relapse Prophylaxis After Hematopoietic Stem Cell Transplantation [Phase 2]
A Phase 2 clinical trial is evaluating the feasibility and safety of donor-derived natural killer cell infusions to prevent leukemia relapse…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: Combination of HMA and Venetoclax With Posaconazole in Patients With Acute Myeloid Leukemia: A Study of Plasma Concentrations
This completed trial reports pharmacokinetic data for a combination of a hypomethylating agent with venetoclax and posaconazole in adults wi…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada
This clinical trial assesses change in disease state in adults with acute myeloid leukemia who are not eligible for intensive chemotherapy, …