Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Safety, Tolerability, PK, PD, and Efficacy of AMG 427 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
This Phase 1 study of AMG 427 in relapsed/refractory acute myeloid leukemia assessed safety, tolerability, PK/PD, and preliminary efficacy; …
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Cardiovascular Function in Acute Leukemia
A completed clinical trial update evaluating cardiovascular function and potential cardiotoxicity in patients with acute leukemia.
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: Lintuzumab-Ac225 in Combination with Cladribine + Cytarabine + Filgastrim + Mitoxantrone (CLAG-M) for Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
Phase 1 clinical trial evaluating lintuzumab-ac225 in combination with CLAG-M for relapsed/refractory acute myeloid leukemia has completed.
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CLINICAL_TRIALS trial_result · 2024-10-02Clinical Trial Update: A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy [Phase 3]
A Phase 3 clinical trial evaluating the combination of IDH1 inhibitor ivosidenib or IDH2 inhibitor enasidenib with induction and consolidati…
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: Fludarabine and Cytarabine Versus High-dose Cytarabine for CBF-AML [Phase 4]
Phase 4 trial comparing fludarabine plus cytarabine versus high-dose cytarabine in core-binding factor acute myeloid leukemia has completed.
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: VA as Maintenance Therapy Post Allo-HSCT in MDS and AML [Phase 2]
A Phase 2 trial evaluating VA as maintenance therapy after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome a…
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CLINICAL_TRIALS trial_result · 2024-09-23Clinical Trial Update: Remote Outpatient Temperature Monitoring for Early Detection of Febrile Neutropenia After Chemotherapy [NA]
This clinical trial evaluated remote outpatient temperature monitoring for early detection of febrile neutropenia in patients undergoing che…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Trial of the FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/Internal Tandem Duplication (ITD) Acute Myeloid Leukemia (AML) [Phase 3]
Phase 3 trial evaluating gilteritinib as maintenance therapy after allogeneic transplant in FLT3-ITD acute myeloid leukemia. The study has c…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Phase IIa Study Evaluating Safety and Efficacy of BL-8040 in Relapsed/Refractory AML Patients [Phase 2]
Phase IIa study evaluating the safety and efficacy of BL-8040 in relapsed/refractory acute myeloid leukemia has completed. Results have been…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Phase 1 First in Human Study of ZN-d5 as a Single Agent [Phase 1]
Phase 1 first-in-human trial of ZN-d5 as a single agent has completed, with study conducted in patients with acute myeloid leukemia and non-…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: CPI-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Granulocytic Sarcoma [Phase 1]
Phase 1 trial evaluating the combination of CPI-613 (devimistat) with cytarabine and mitoxantrone hydrochloride in relapsed or refractory ac…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Venetoclax and Quizartinib in Treating Patients With FLT3-mutated Recurrent or Refractory Acute Myeloid Leukemia [Phase 1, Phase 2]
A Phase 1/2 trial evaluating venetoclax plus quizartinib in FLT3-mutated acute myeloid leukemia was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Clinical Trial to Evaluate Clifutinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia(AML) [Phase 1]
Phase 1 clinical trial evaluating clifutinib in patients with relapsed or refractory acute myeloid leukemia has completed.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS [Phase 1]
Phase I study of CYC140, a PLK-1 inhibitor, in advanced leukemias and myelodysplastic syndromes has been terminated.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory AML or MDS [Phase 1]
This Clinical Trial Update reports that a Phase 1 study of CYC065 in combination with Venetoclax for relapsed or refractory acute myeloid le…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: IDH2-Post-Allo-Trial for Patients with IDH2-mut Myeloid Neoplasms After Allo-SCT [Phase 2]
This is a Phase 2 trial evaluating IDH2-mutant myeloid neoplasms after allogeneic stem cell transplantation. The study status is completed.
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CLINICAL_TRIALS trial_result · 2024-09-05Clinical Trial Update: Safety, Tolerability and Efficacy of the BL-8040 and Atezolizumab for Maintenance Treatment in Subjects With Acute Myeloid Leukemia (AML) [Phase 1, Phase 2]
Phase 1/2 trial of BL-8040 plus atezolizumab as maintenance therapy in acute myeloid leukemia; the study was terminated and results were pos…
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CLINICAL_TRIALS trial_result · 2024-09-05Clinical Trial Update: A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems [Phase 1]
Takeda announced results from a Phase 1 study of pevonedistat in people with blood cancers and solid tumors who also have kidney or liver im…
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CLINICAL_TRIALS trial_result · 2024-09-04Clinical Trial Update: Study of Venetoclax in Combination With Azacytidine in AML Patients Selected Using Ex Vivo Drug Sensitivity Screening [Phase 2]
A Phase 2 study evaluating the combination of venetoclax and azacitidine in AML patients selected by ex vivo drug sensitivity screening has …
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CLINICAL_TRIALS trial_result · 2024-09-03Clinical Trial Update: A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma [Phase 1]
Pfizer's Phase 1 trial of Maplirpacept (PF-07901801) in advanced hematologic malignancies, including diffuse large B-cell lymphoma, acute my…
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CLINICAL_TRIALS trial_result · 2024-08-29Clinical Trial Update: MGTA-145 + Plerixafor in the Mobilization of HSCs for Allogeneic Transplant in Hematologic Malignancies [Phase 2]
Phase 2 study evaluating MGTA-145 in combination with Plerixafor for mobilizing hematopoietic stem cells for allogeneic transplantation in h…
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CLINICAL_TRIALS trial_result · 2024-08-23Clinical Trial Update: Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis [Phase 2, Phase 3]
Phase 2/Phase 3 trial evaluating a combination of post-transplant cyclophosphamide, abatacept, vedolizumab, and baricitinib to prevent graft…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: CHG Combined With Venetoclax and Azacytidine in Newly Diagnosed AML [Phase 2]
A Phase 2 clinical trial is evaluating CHG-based chemotherapy in combination with venetoclax and azacitidine for newly diagnosed acute myelo…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: Study of CFI-400945 Fumarate in Patients With Relapsed or Refractory AML or MDS [Phase 1]
Phase 1 trial of CFI-400945 fumarate in relapsed or refractory acute myeloid leukemia and myelodysplastic syndromes has completed.
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: SL-401 as Consolidation Therapy in Patients With Adverse Risk Acute Myeloid Leukemia in First Complete Remission [Phase 1, Phase 2]
Clinical trial update reports results for SL-401 as consolidation therapy in adverse-risk acute myeloid leukemia in first complete remission…