Acute Myeloid Leukemia
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: EX02 CAR-T Cells for Relapsed and Refractory Acute Myeloid Leukemia [EARLY_Phase 1]
An early-phase 1 clinical trial evaluating EX02 CAR-T cells for relapsed and refractory acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: A Phase Ib Study of APG-115 Single Agent or in Combination With Azacitidine or Cytarabine in Patients With AML and MDS. [Phase 1]
Phase Ib clinical trial of APG-115 as a single agent or in combination with azacitidine or cytarabine for acute myeloid leukemia or myelodys…
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CLINICAL_TRIALS research · 2024-10-10Clinical Trial Update: Efficacy of Venetoclax Combined with Intensive Chemotherapy in Different Subgroups of AML [Phase 2]
A Phase 2 trial assessing venetoclax with intensive chemotherapy in different subgroups of acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2024-10-04Clinical Trial Update: Integrative "Omics" Approaches for Leukemia Target Identification and Matched Therapeutic Intervention [NA]
The study uses integrative 'omics' approaches to identify leukemia targets and matched therapeutic interventions and is currently recruiting…
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CLINICAL_TRIALS research · 2024-10-03Clinical Trial Update: Venetoclax + Decitabine vs. "7+3" Induction Chemotherapy in Young AML [Phase 3]
This Phase 3 trial compares venetoclax plus decitabine with standard 7+3 induction chemotherapy in young adults with acute myeloid leukemia.
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CLINICAL_TRIALS research · 2024-10-01Clinical Trial Update: Mitoxantrone Hydrochloride Liposome in Combination With Cytarabine and Venetoclax Regimen in Newly Diagnosed Elderly AML [Phase 2]
Clinical trial update on a Phase 2 study of mitoxantrone hydrochloride liposome with cytarabine and venetoclax in newly diagnosed elderly ac…
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CLINICAL_TRIALS research · 2024-09-25Clinical Trial Update: Twice-per-weekSelinexor, 2 Days Melphalan [Phase 3]
Phase 3 trial of twice-weekly selinexor with two days of melphalan for acute myeloid leukemia; study status is not yet recruiting.
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CLINICAL_TRIALS research · 2024-09-25Clinical Trial Update: Expanded Access to Provide GL-ONC1 for the Treatment of Advanced Cancers With No Standard of Care
Expanded access program for GL-ONC1 in patients with advanced solid tumors and acute myeloid leukemia is no longer available.
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CLINICAL_TRIALS research · 2024-09-20Clinical Trial Update: Exploring Disease Immunogenicity and the Immunological Effects of Hypomethylating Agents in Acute Myeloid Leukemia
ClinicalTrials.gov entry describing an active-but-not-recruiting study evaluating immunogenicity and the immunological effects of hypomethyl…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Tolerability and Efficacy of Midostaurin to 10-day Decitabine in Unfit Adult AML and High Risk MDS Patients [Phase 2]
Phase 2 clinical trial evaluating tolerability and efficacy of adding midostaurin to a 10-day decitabine regimen in unfit adults with acute …
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: TMLI Plus Chemotherapy in High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia [Phase 2]
A Phase 2 clinical trial evaluating total marrow and lymphoid irradiation (TMLI) with chemotherapy for high-risk myelodysplastic syndromes a…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: TMLI/Fludarabine/Melphalan Conditioning for Allogeneic Transplantation in High-risk Myelodysplastic Syndrome or Acute Myeloid Leukemia. [Phase 2]
Phase 2 clinical trial evaluating total marrow irradiation-based conditioning with fludarabine and melphalan for allogeneic transplantation …
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CLINICAL_TRIALS research · 2024-08-28Clinical Trial Update: Immunotherapy With ex Vivo Expanded Haploidentical Natural Killer Cells for Children/Young Adults With AML [Phase 1, Phase 2]
Clinical trial update for immunotherapy using ex vivo expanded haploidentical natural killer cells in children and young adults with acute m…
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CLINICAL_TRIALS research · 2024-08-28Clinical Trial Update: Expanded Haploidentical Natural Killer Cells as Consolidation Strategy for Children/Young Adults With AML [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating expanded haploidentical natural killer cells as a consolidation therapy for children and young adults …
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CLINICAL_TRIALS research · 2024-08-26Clinical Trial Update: RIC Allo-HSCT vs. Venetoclax-Based Consolidation in Elderly AML Patients After First CR [Phase 4]
Phase 4 clinical trial comparing reduced-intensity conditioned allogeneic stem cell transplant against venetoclax-based consolidation in eld…
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CLINICAL_TRIALS research · 2024-08-22Clinical Trial Update: Clinical Study of Induction Therapy Options Based on Molecular Subtyping and MRD in Children and Adolescents With AML [Phase 2]
A Phase 2 clinical trial in children and adolescents with acute myeloid leukemia evaluating induction therapy options based on molecular sub…
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CLINICAL_TRIALS research · 2024-08-22Clinical Trial Update: Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation [Phase 2]
This notice describes a Phase 2 clinical trial evaluating avapritinib for relapsed or refractory pediatric core-binding factor acute myeloid…
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CLINICAL_TRIALS research · 2024-08-19Clinical Trial Update: Hema-NeoTIL01 Cell Infusion Therapy in Relapsed/Refractory Acute Leukemia [EARLY_Phase 1]
This is an early Phase 1 trial update for Hema-NeoTIL01 cell infusion therapy in relapsed/refractory acute leukemia, including acute myeloid…
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CLINICAL_TRIALS research · 2024-08-13Clinical Trial Update: A Clinical Trial of TQB3455 Tablets in Patients With Hematological Malignancies [Phase 1]
Phase 1 clinical trial of TQB3455 tablets for hematological malignancies is currently recruiting in patients with acute myeloid leukemia and…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Individual Patient Compassionate Use of Crenolanib
Clinical trial update indicating that crenolanib is available for individual patient compassionate use in cancers with FLT3-ITD/FLT3-TKD mut…
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CLINICAL_TRIALS research · 2024-08-07Clinical Trial Update: Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR [Phase 2, Phase 3]
A multi-arm Phase 2/Phase 3 study in adults with acute myeloid leukemia compares daunorubicin versus high-dose idarubicin induction, high-do…
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CLINICAL_TRIALS research · 2024-08-07Clinical Trial Update: Safety and Efficacy of NK520 to Treat Relapsed/Refractory Acute Myeloid Leukemia [EARLY_Phase 1]
An early-phase 1 clinical trial evaluating the safety and potential efficacy of NK520 for relapsed/refractory acute myeloid leukemia, curren…
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CLINICAL_TRIALS research · 2024-08-05Clinical Trial Update: Safety and Efficacy of Venetoclax, Cytarabine and Metformin (VenCM) for Relapsed-Refractory and Induction-Ineligible Acute Myeloid Leukemia [Phase 2]
A Phase 2 clinical trial evaluating the safety and efficacy of venetoclax, cytarabine, and metformin in relapsed/refractory or induction-ine…
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CLINICAL_TRIALS research · 2024-08-05Clinical Trial Update: VA Combined With PD-1 Inhibitor for the Treatment of Relapsed and Refractory AML and High-risk MDS [Phase 2]
A Phase 2 clinical trial is evaluating the combination of a VA agent with a PD-1 inhibitor for relapsed or refractory acute myeloid leukemia…
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CLINICAL_TRIALS research · 2024-08-02Clinical Trial Update: Clinical Trial Protocol for the Combined Use of VAG in the Treatment of ND-AML [NA]
This document outlines a clinical trial protocol for the combined use of VAG in newly diagnosed acute myeloid leukemia and indicates that re…