Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-07-16Clinical Trial Update: A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Greece
An ongoing clinical trial in Greece is evaluating changes in disease state in adults with acute myeloid leukemia who are ineligible for inte…
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CLINICAL_TRIALS research · 2025-07-14Clinical Trial Update: Feasibility and Safety of Home Blood Count Measurement and Transfusions in Patients With Acute Myeloid Leukemia [NA]
This study explores whether patients with acute myeloid leukemia can safely measure blood counts at home and receive transfusions. It is cur…
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CLINICAL_TRIALS research · 2025-07-14Clinical Trial Update: Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1, Phase 2]
This document provides an update on an ongoing Phase 1/Phase 2 clinical trial evaluating CD33-targeted CAR-T cells (CD33CART) in children an…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Administration of Donor T Cells With the Caspase-9 Suicide Gene [Phase 1]
A Phase 1 trial evaluating donor T cells engineered with a caspase-9 suicide gene to enable controlled safety in hematologic diseases.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Incidence and Risk Factors for the Development of Invasive Fungal Infection in Patients Diagnosed With Acute Myeloblastic Leukemia (HIFA)
This clinical trial update examines the incidence and risk factors for invasive fungal infections in patients diagnosed with acute myeloid l…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling [Phase 1]
Phase 1 clinical trial evaluating ex vivo drug sensitivity testing and multi-omics profiling in pediatric cancers. Recruitment is ongoing ac…
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: CPX-351 or CLAG-M Regimen for the Treatment of Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms in Medically Less-Fit Patients [Phase 2]
A Phase 2 clinical trial update evaluating CPX-351 (Vyxeos) or CLAG-M regimen for acute myeloid leukemia or other high-grade myeloid neoplas…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: VAM in Secondary AML, AML With Extramedullary Involvement, and Myeloid Sarcoma [Phase 2]
Phase 2 clinical trial evaluating the VAM regimen in secondary acute myeloid leukemia, AML with extramedullary involvement, and myeloid sarc…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: 90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome [Phase 1]
Phase 1 clinical trial of a radiolabeled anti-CD25 antibody with fludarabine, melphalan, and total marrow and lymphoid irradiation for high-…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: A Randomized Phase II Study of Hyperbaric Oxygen in Improving Engraftment in Umbilical Cord Blood Stem Cell Transplant [Phase 2]
A Phase II randomized trial evaluating hyperbaric oxygen to improve engraftment after umbilical cord blood stem cell transplantation in pati…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation [Phase 2]
Phase 2 trial evaluating maintenance therapy with ivosidenib after allogeneic stem cell transplantation in patients with acute myeloid leuke…
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Allo HSCT Using RIC and PTCy for Hematological Diseases [Phase 2]
Phase 2 clinical trial evaluating allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning and post-transplan…
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML [Phase 1]
Phase 1 trial of CD33KO-HSPC infusion followed by CART-33 infusion for refractory/relapsed acute myeloid leukemia is recruiting.
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS Patients [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of combining hydroxyurea with valproic acid or 6-mercaptopurine with valproic acid in…
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML [Phase 1]
Phase 1 clinical trial update for GTB-3650 Trike in high-risk myeloid malignancies, including acute myeloid leukemia and myelodysplastic syn…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations [Phase 1]
Phase 1 study of oral LY3410738 in patients with IDH1/IDH2-mutant hematologic malignancies is currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning [Phase 2]
Phase 2 trial evaluating vedolizumab with post-transplant cyclophosphamide and tacrolimus to prevent graft-versus-host disease in patients u…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: Lentivirally Redirected CD123 Autologous T Cells in AML [Phase 1]
A Phase 1 clinical trial update evaluating lentivirally redirected CD123 autologous T cells for acute myeloid leukemia; the study is active …
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: Acute Myeloid Leukemia and Markers of Leukemia Stem Cells (CLL1 and CD45RA)
A clinical trial examining acute myeloid leukemia and leukemia stem cell markers CLL1 and CD45RA is currently recruiting, sponsored by Suhu …
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CLINICAL_TRIALS research · 2025-06-25Clinical Trial Update: Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS) [Phase 2]
A Phase 2 clinical trial evaluating intensity-modulated total marrow irradiation in fully matched and partially matched allogeneic transplan…
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CLINICAL_TRIALS research · 2025-06-25Clinical Trial Update: Clinical Study of U32 in Patients With Acute Myeloid Leukemia [Phase 1, Phase 2]
A phase 1/2 clinical trial of the investigational agent U32 in patients with acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders [Phase 2]
Phase 2 clinical trial evaluating myeloablative allogeneic hematopoietic stem cell transplantation from related or unrelated donors for a br…
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CLINICAL_TRIALS research · 2025-06-15Clinical Trial Update: Early Prophylactic Donor Lymphocyte Infusion After Allo-HSCT for Patients With AML [Phase 2]
This clinical trial update describes a Phase 2 study of early prophylactic donor lymphocyte infusion after allogeneic stem cell transplantat…
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CLINICAL_TRIALS research · 2025-06-11Clinical Trial Update: CRISPR-Edited Allogeneic Anti-CLL-1 CAR-T Cell Therapy in Patients With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
Phase 1 clinical trial update of CRISPR-edited allogeneic anti-CLL-1 CAR-T cells for relapsed or refractory acute myeloid leukemia; the stud…
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CLINICAL_TRIALS research · 2025-06-10Clinical Trial Update: Oral-ATO for TP53-mutated Myeloid Malignancies [Phase 2]
A Phase 2 clinical trial evaluating oral arsenic trioxide for TP53-mutated myeloid malignancies, including acute myeloid leukemia and myelod…